34813-97-3

Basic information

• Product Name: 2-(FORMYLAMINO)PYRIDINE
• Synonyms: 2-(FORMYLAMINO)PYRIDINE;N-PYRIDIN-2-YL-FORMAMIDE;N-(2-PYRIDYL)FORMAMIDE;N-2-pyridinyl-ForMaMide
• CAS NO: 34813-97-3
• Molecular Formula: C₆H₆N₂O
• Molecular Weight: 122.12
• Mol File: 34813-97-3.mol

Chemical Properties

• Melting Point: 69-71 °C
• Boiling Point: 314.7 °C at 760 mmHg
• Flash Point: 144.1 °C
• Appearance: /
• Density: 1.228 g/cm³
• Vapor Pressure: 0.000457mmHg at 25°C
• Refractive Index: 1.602
• Solubility: methanol: 0.1 g/mL, clear
• PKA: 13.69±0.70(Predicted)
• CAS DataBase Reference: 2-(FORMYLAMINO)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(FORMYLAMINO)PYRIDINE(34813-97-3)
• EPA Substance Registry System: 2-(FORMYLAMINO)PYRIDINE(34813-97-3)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 34813-97-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(FORMYLAMINO)PYRIDINE is used as a building block for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique chemical structure allows for the creation of diverse molecules with potential medicinal properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(FORMYLAMINO)PYRIDINE serves as a key component in the production of agrochemicals, such as pesticides and herbicides. Its reactivity and stability make it suitable for the development of effective and environmentally friendly agricultural products.
Used in Fine Chemicals Industry:
2-(FORMYLAMINO)PYRIDINE is utilized as a building block in the synthesis of fine chemicals, which are high-purity chemicals used in various applications, including fragrances, dyes, and specialty chemicals. Its versatility in organic synthesis enables the production of a wide range of high-quality fine chemicals.
Used as a Reagent in Synthesis of Heterocyclic Compounds:
2-(FORMYLAMINO)PYRIDINE is employed as a reagent in the synthesis of heterocyclic compounds, which are an important class of organic compounds with applications in pharmaceuticals, agrochemicals, and materials science. Its chemical reactivity facilitates the formation of complex heterocyclic structures with potential applications in various industries.
Used as a Reagent in Synthesis of Coordination Complexes:
In coordination chemistry, 2-(FORMYLAMINO)PYRIDINE is used as a reagent for the synthesis of coordination complexes. These complexes have applications in catalysis, materials science, and medicinal chemistry, where they can exhibit unique properties and functions due to their metal-ligand interactions.

InChI:InChI=1/C6H6N2O/c9-5-8-6-3-1-2-4-7-6/h1-5H,(H,7,8,9)

Upstream product

• 504-29-0 2-aminopyridine 
• 67-66-3 chloroform 
• 77287-34-4 formamide 
• 32654-45-8 chlorohydrate d'amino-2 pyridine 

Downstream Products

• 333725-83-0 N-{2-[(2-dimethylamino-5-fluoro-phenyl)-(pyridin-2-ylamino)-methyl]-4-fluoro-phenyl}-N-methyl-formamide 
• 333725-84-1 N-{4-chloro-2-[(5-chloro-2-dimethylamino-phenyl)-(pyridin-2-ylamino)-methyl]-phenyl}-N-methyl-formamide 
• 333725-85-2 N-{4-bromo-2-[(5-bromo-2-dimethylamino-phenyl)-(pyridin-2-ylamino)-methyl]-phenyl}-N-methyl-formamide 
• 603-48-5 tris[4-(dimethylamino)phenyl]methane 
• 333725-81-8 N-{2-[(2-dimethylamino-5-methyl-phenyl)-(pyridin-2-ylamino)-methyl]-4-methyl-phenyl}-N-methyl-formamide 
• 408507-33-5 N-ethyl-N-(2-pyridyl)formamide 
• 92245-13-1 3-phenyl-N-(pyridin-2-yl)propanamide 
• 332402-98-9 2-phenyl-N-(pyridin-2-yl)propanamide 
• 544459-32-7 N-(2-pyridyl)-3-cyclohexyl propanamide 
• 4589-12-2 N-(pyrid-2-yl)benzamide 
• 504-29-0 2-aminopyridine 
• 579470-27-2 N-(2-pyridyl)-4,4-dimethyl pentanamide 
• 14547-80-9 4-methyl-N-(pyridine-2-yl)benzamide 

Relevant articles and documents

An Environmentally Benign, Catalyst-Free N?C Bond Cleavage/Formation of Primary, Secondary, and Tertiary Unactivated Amides

Herein, we report an operationally simple, cheap, and catalyst-free method for the transamidation of a diverse range of unactivated amides furnishing the desired products in excellent yields. This protocol is environmentally friendly and operates under extremely mild conditions without using any promoter or additives. Significantly, this strategy has been implied in the chemoselective synthesis of a pharmaceutical molecule, paracetamol, on a gram-scale with excellent yield. We anticipate that this universally applicable strategy will be of great interest in drug discovery, biochemistry, and organic synthesis.

Synthesis and reactions of aromatic and heterocyclic isocyanides

Reactions of halo-and nitroanilines with dichlorocarbene resulted in formation of the corresponding isocyanides in poor yields. Better results are obtained by treatment with phosphoryl chloride of formanilides having the same substituents. The latter procedure was used to prepare previously inaccessible derivatives of 2-pyridyl, 2-thiazolyl, and 1,3,4-thiadiazol-2-yl isocyanides. To prevent polymerization, the isocyanides were isolated as complexes with copper(I) bromide which can be decomposed with aqueous potassium cyanide to release free isocyanides. Aryl and heteryl isocyanides reacted with such nucleophiles as water and dimethylamine under mild conditions.