6972-69-6

Basic information

• Product Name: N,N-DIMETHYLNICOTINAMIDE
• Synonyms: dimethylnicotinamide;N,N-DIMETHYLNICOTINAMIDE;3-Pyridinecarboxamide,N,N-dimethyl-(9CI);NICOTINAMIDE, N,N-DIMETHYL- (8CI);3-(Dimethylcarbamoyl)pyridine;N,N-Dimethylpyridine-3-carboxamide;3-Pyridinecarboxamide, N,N-dimethyl-;3-Pyridinecarboxylic acid,amide,N,N-dimethyl
• CAS NO: 6972-69-6
• Molecular Formula: C₈H₁₀N₂O
• Molecular Weight: 150.18
• EINECS: 230-209-4
• Product Categories: AMIDE
• Mol File: 6972-69-6.mol

Chemical Properties

• Melting Point: 44°C
• Boiling Point: 147 °C / 9mmHg
• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: N,N-DIMETHYLNICOTINAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-DIMETHYLNICOTINAMIDE(6972-69-6)
• EPA Substance Registry System: N,N-DIMETHYLNICOTINAMIDE(6972-69-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 6972-69-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
N,N-DIMETHYLNICOTINAMIDE is used as a precursor in the synthesis of various pharmaceuticals and organic compounds, contributing to the development of new drugs and therapies.
Used in Anti-inflammatory and Anti-fibrotic Applications:
N,N-DIMETHYLNICOTINAMIDE is used as an anti-inflammatory and anti-fibrotic agent, potentially aiding in the treatment of conditions characterized by inflammation and tissue scarring.
Used in Metabolic Disorders Treatment:
N,N-DIMETHYLNICOTINAMIDE is used as a therapeutic agent for treating metabolic disorders, leveraging its potential to modulate metabolic pathways and improve health outcomes.
Used in Neurological Conditions Therapy:
N,N-DIMETHYLNICOTINAMIDE is used as a possible therapeutic agent for certain neurological conditions, exploring its capacity to address specific neurological issues.
Used in Organic Light-Emitting Diode (OLED) Devices:
N,N-DIMETHYLNICOTINAMIDE is used in the development of OLED devices due to its beneficial electronic and optical properties, enhancing the performance and efficiency of these technologies.

Upstream product

• 10400-19-8 3-pyridinecarbonyl chloride 
• 506-59-2 N,N-dimethylammonium chloride 
• 614-18-6 3-pyridinecarboxylic acid ethyl ester 
• 84738-97-6 methylchloroaluminum N,N-dimethylamide 
• 677-22-5 tert-butylmagnesium chloride 
• 52943-21-2 2-chloropyridine-3-carboxylic acid N,N-dimethylamide 
• 500-22-1 3-pyridinecarboxaldehyde 
• 124-40-3 dimethyl amine 
• 59-67-6 nicotinic acid 
• 79-44-7 N,N-Dimethylcarbamoyl chloride 
• 626-55-1 3-Bromopyridine 
• 68-12-2 N,N-dimethyl-formamide 
• 373-68-2 tetramethylammonium fluoride 
• 98-92-0 nicotinamide 

Downstream Products

• 132778-92-8 1-(2,6-dichloro-benzyl)-3-dimethylcarbamoyl-pyridinium; bromide 
• 58287-38-0 3-dimethylcarbamoyl-1-methyl-pyridinium; iodide 
• 500-22-1 3-pyridinecarboxaldehyde 
• 77924-13-1 N,N-Dimethyl-4-(pyridine-3-carbonyl)-nicotinamide 
• 59-26-7 N,N-diethylnicotinamide 
• 113944-88-0 1-(2,6-dichloro-benzyl)-1,4-dihydro-pyridine-3-carboxylic acid dimethylamide 
• 5505-20-4 N,N-dimethyl-3-piperidinecarboxamide 
• 100-54-9 pyridine-3-carbonitrile 
• 59547-43-2 1-benzyl-1,4-dihydro-pyridine-3-carboxylic acid dimethylamide 
• 111991-09-4 nicosulfuron 
• 14548-44-8 3-(4-chlorobenzoyl)pyridine 
• 1402916-79-3 3-(dimethylcarbamoyl)-1-(((2-(4-isobutylphenyl)propanoyl)oxy)methyl)pyridin-1-ium iodide 
• 1402916-74-8 1-((((((1S,2R)-1-benzamido-3-(((2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-diacetoxy-12-(benzoyloxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[l,2-b]oxet-9-yl)oxy)-3-oxo-1-phenylpropan-2-yl)oxy)carbonyl)oxy)methyl)-3-(dimethylcarbamoyl)pyridin-1-ium iodide iodomethyl 2-(4-isobutylphenyl)propanoate 
• 1402916-56-6 1-((((4-acetamidophenoxy)carbonyl)oxy)methyl)-3-(dimethylcarbamoyl)pyridin-1-ium iodide 

Relevant articles and documents

Palladium-Catalyzed Aminocarbonylation of Aryl Halides with N,N-Dialkylformamide Acetals

We developed a protocol for the palladium-catalyzed aminocarbonylation of aryl halides using less-toxic formamide acetals as bench-stable aminocarbonyl sources under neutral conditions. Various aryl (including heteroaryl) halides reacted with N,N-dialkylformamide acetals in the presence of a catalytic amount of tris(dibenzylideneacetone)dipalladium(0)-chloroform adduct and xantphos to give the corresponding aromatic carboxamides at 90–140 °C without any activating agents or bases in up to quantitative chemical yield. This protocol was applied to aryl bromides, aryl iodides, and trifluoromethanesulfonic acid, as well as to relatively less-reactive aryl chlorides. A wide range of functionalities on the aromatic ring of the substrates were tolerated under the aminocarbonylation conditions. The catalytic aminocarbonylation was used to prepare the insect repellent N,N-diethyl-3-methylbenzamide as well as a synthetic intermediate of the dihydrofolate reductase inhibitor triazinate.

Selective Methylation of Amides, N-Heterocycles, Thiols, and Alcohols with Tetramethylammonium Fluoride

We herein disclose the use of tetramethylammonium fluoride (TMAF) as a direct and selective methylating agent of a variety of amides, indoles, pyrroles, imidazoles, alcohols, and thiols. The method is characterized by operational simplicity, wide scope, and ease of purification. Our computational studies suggest a concerted methylation-deprotonation as the preferred reaction pathway.

POCl3 promoted metal-free synthesis of tertiary amides by coupling of carboxylic acids and N,N-disubstituted formamides

Herein we report a robust and synthetically useful catalyst-free amination methodology by the coupling of carboxylic acids and N-substituted formamides using POCl3 as a promoter. Versatile amides with a wide array of substituent groups were prepared within only 1 h in good to excellent yields. And even multi-substituted aromatic carboxylic acids could give the desired products with satisfactory results.

Synthesizing method of raw nicosulfuron

The invention provides a synthesizing method of raw nicosulfuron. The method includes: synthesizing N,N-dimethyl nicotinamide, oxidizing the N,N-dimethyl nicotinamide, performing the sulfonylation of2-carbamido-4,6-dimethoxy pyrimidine, and synthesizing the raw nicosulfuron. The synthesizing method is short in synthesizing route, low in cost, high in yield, mild in synthesizing conditions, capable of avoiding the use of high-toxicity and high-pollution raw materials such as phosphorus oxychloride, chlorine and phosgene, green and safe, and capable of achieving industrial production.

Method for synthesizing phosphorus-oxychloride-promoted amide compound

The invention relates to a method for synthesizing a phosphorus-oxychloride-promoted amide compound. The synthesizing method includes the steps that carboxylic acid serves as one reactant, another reactant (N,N-dialkyl methanamide) serves as a solvent, one equivalent of phosphorus oxychloride is added, and the amide compound is prepared. The reaction substrates are low in price and easy to get, the nature is stable, toxicity is small, the reaction speed is high, conditions are moderate, and the reaction substrates can be widely applied to substrates with different functional groups. The efficiently-constructed amide compound is an important molecular skeleton for many medicines, bioactive molecules and natural products, and the synthesizing method is a widely-applicable preparing method for synthesizing the compound.

Ru-catalyzed direct amidation of carboxylic acids with N-substituted formamides

The direct amidation of carboxylic acids with N-substituted formamides has been accomplished via ruthenium catalysis. In the presence of ruthenium catalyst, a versatile range of carboxylic acids and N-substituted formamides undergoes amidation reaction to produce synthetically useful amides in good yields. C[dbnd]O in amide product came from benzoic acid but not N-substituted formamides, and which was confirmed by Isotope experiment.

Palladium-Catalyzed Aminocarbonylation of Aryl Halides with 2,4,6-Trichloro-1,3,5-triazine/Formamide Mixed Reagent

In this work, the mixture of formamide and 2,4,6-trichloro-1,3,5-triazine (cyanuric chloride or TCT) is introduced as a new amidating agent in Pd-catalyzed aminocarbonylation of aryl halides. In the presence of a catalytic amount of palladium and TCT/formamide reagent, a range of aryl halides (X = Cl, Br, I) were converted into amides efficiently in N,N-dimethylformamide at 120 °C. The 2,4,6-trichloro-1,3,5-triazine/formamide mixed reagent was found to be an efficient amidating agent in Pd-catalyzed aminocarbonylation of aryl halides. In the presence of this reagent and a catalytic amount of Pd, a range of amides were synthesized by using aryl halides.

PROCESS FOR PREPARATION OF N,N-DI SUBSTITUTED CARBOXAMIDES

The present disclosure relates to a single pot process for preparation of a N,N-di substituted carboxamide compounds of formula (I), said process comprising: reacting a carboxylic acid with a di-substituted carbamoyl chloride in presence of an organic tertiary base to obtain the N,N-di substituted carboxamide compounds of formula (I). The process of the present disclosure involves a simple step, and it is energy and time saving process for preparation of N,N-di substituted carboxamides.

PROCESS FOR PREPARATION OF N,N-DI SUBSTITUTED CARBOXAMIDES

The present disclosure relates to a single pot process for preparation of a N,N-di substituted carboxamide compounds of formula (I), said process comprising: reacting a carboxylic acid with a di-substituted carbamoyl chloride in presence of an organic tertiary base to obtain the N,N-di substituted carboxamide compounds of formula (I). The process of the present disclosure involves a simple step, and it is energy and time saving process for preparation of N, N-di substituted carboxamides.

Preparation of N,N-dimethyl aromatic amides from aromatic aldehydes with dimethylamine and iodine reagents

Various N,N-dimethyl aromatic amides were obtained in good to moderate yields by the reaction of aromatic aldehydes with aqueous dimethylamine in the presence of molecular iodine or 1,3-diiodo-5,5-dimethylhydantoin (DIH) at room temperature. Under the same conditions and using the same procedure, treatment of aromatic aldehydes and morpholine in the presence of DIH also provided the corresponding N-aroyl morpholines in good to moderate yields. Georg Thieme Verlag Stuttgart · New York.