7499-06-1

Basic information

• Product Name: 5-Chloro-2-methylbenzoic acid
• Synonyms: 3-CHLORO-6-METHYLBENZOIC ACID;5-CHLORO-2-METHYLBENZOIC ACID;5-CHLORO-O-TOLUIC ACID;RARECHEM AL BO 0471;5-Chloro-2-methylbenzoic;4-(CHLOROMETHYL)BENZOIC ACID 99+%;5-Chloro-o-toluic acid, 2-Carboxy-4-chlorotoluene;o-Toluic acid, 5-chloro-
• CAS NO: 7499-06-1
• Molecular Formula: C₈H₇ClO₂
• Molecular Weight: 170.59
• Product Categories: Acids and Derivatives;Aromatic Nitriles;Benzoic acid;Organic acids;C7;Carbonyl Compounds;Carboxylic Acids;Building Blocks;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Organic Building Blocks
• Mol File: 7499-06-1.mol

Chemical Properties

• Melting Point: 168 °C
• Boiling Point: 293.5 °C at 760 mmHg
• Flash Point: 131.3 °C
• Appearance: /
• Density: 1.31 g/cm³
• Vapor Pressure: 0.000782mmHg at 25°C
• Refractive Index: 1.573
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: soluble in Methanol
• PKA: 3.50±0.25(Predicted)
• CAS DataBase Reference: 5-Chloro-2-methylbenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-2-methylbenzoic acid(7499-06-1)
• EPA Substance Registry System: 5-Chloro-2-methylbenzoic acid(7499-06-1)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-41-37/38-22
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 7499-06-1(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C8H7ClO2/c1-5-2-3-6(9)4-7(5)8(10)11/h2-4H,1H3,(H,10,11)

Upstream product

• 118-90-1 ortho-methylbenzoic acid 
• 50712-70-4 5-chloro-2-methylbenzonitrile 
• 98588-89-7 5,β,β-trichloro-2-methyl-styrene 
• 124-38-9 carbon dioxide 
• 95-73-8 2,4-dichlorotoluene 
• 18964-63-1 2-Methyl-5-chlor-benzotrichlorid 
• 7782-50-5 chlorine 
• 64-19-7 acetic acid 
• 67-66-3 chloroform 
• 615-60-1 4-chloro-1,2-dimethylbenzene 
• 7697-37-2 nitric acid 
• 95-79-4 5-chloro-2-methyl-benzenamine 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 103039-12-9 2-methyl-4-methoxy-5-chloracetophenone 

Downstream Products

• 89-20-3 4-chlorophthalic acid 
• 21900-40-3 5-chloro-2-methylbenzoyl chloride 
• 99585-13-4 methyl 2-methyl-5-chlorobenzoate 
• 179096-93-6 N-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-5-chloro-2-methyl-N-(1-methyl-1-phenyl-ethyl)-benzamide 
• 1027141-71-4 N-{2-[(tert-butyldiphenylsilyl)oxy]ethyl}-2-{4-[2-({2-[(tert-butyldiphenylsilyl)oxy]ethyl}(1-methyl-1-phenylethyl)carbamoyl)-4-chlorophenyl]-3-oxobutyl}-N-(1-ethylcyclopentyl)benzamide 
• 85304-05-8 5-chloro-2-methylbenzohydrazide 
• 85303-95-3 3-(5-Chloro-2-methyl-phenyl)-5-phenyl-1H-[1,2,4]triazole 
• 85303-96-4 3-(5-Chloro-2-methyl-phenyl)-5-(3-methoxy-phenyl)-1H-[1,2,4]triazole 
• 57800-72-3 5-Chlor-2,4'-dimethyl-benzophenon 
• 33184-55-3 5-chloro-2-methyl-benzophenone 
• 33184-56-4 2-benzoyl-4-chlorobenzoic acid 
• 56427-54-4 5-chloro-2-methyl-benzoic acid ethyl ester 
• 154257-81-5 5-chloro-2-methyl-3-nitrobenzoic acid 
• 1193779-97-3 1-(5-chloro-2-methylphenyl)propan-1-one 

Relevant articles and documents

HYDANTOIN DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISORDERS

This invention relates to compounds of Formula (1) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF- or combinations thereof.

PROCESS FOR PRODUCTION OF IODINE COMPOUNDS AND PROCESS FOR PRODUCTION OF HIGH-PURITY 5-IODO-2-METHYLBENZOIC ACID

Provided is a production method for an iodine compound in which iodine is reacted with a substrate in the presence of a porous material having a pore diameter of 500 nm or less or in the presence of the above porous material and an oxidizing agent and a production process for high purity 5-iodo-2-methylbenzoic acid comprising an iodination reaction step carried out by the above-mentioned, a crystal precipitation and separation step in which a product is precipitated by adding water or cooling and then separated and a purification step in which crystal separated is recrystallized using an organic solvent. According to the production method for an iodine compound described above, iodine can be introduced into various substrates at a high selectivity. Since expensive metals and specific reagents do not have to be used, it can readily be carried out in an industrially scale, and the product having a high purity can be obtained. Further, the process comprising the iodination reaction, separation and purification steps described above makes it possible to readily obtain at a high yield, 5-iodo-2-methylbenzoic acid having a high purity which is useful in uses for functional chemical products such as medicines. The process of the present invention comprising iodination reaction, separation and purification steps is characterized by that it is simple in terms of a procedure and that the purification load is smaller, and it is very advantageous in industrially carrying out.

Electrosynthesis of aryl-carboxylic acids from chlorobenzene derivatives and carbon dioxide

The electrocarboxylation of a large variety of chlorobenzenic compounds is achieved in N,N-dimethylformamide by constant current electrolysis between a stainless steel cathode and a sacrificial magnesium anode in a diaphragmless cell. Substituted benzoic acids are obtained in high yield in simle conditions thus avoiding the usual preparation of organometallic intermediates.