82652-17-3

Basic information

• Product Name: 1-(4-FLUOROPHENYL)-2-(METHYLSULFONYL)-1-ETHANONE
• Synonyms: 1-(4-FLUOROPHENYL)-2-(METHYLSULFONYL)-1-ETHANONE
• CAS NO: 82652-17-3
• Molecular Formula: C9H9FO3S
• Molecular Weight: 216.23
• Mol File: 82652-17-3.mol

Chemical Properties

• Melting Point: 111-113°C
• Appearance: /
• CAS DataBase Reference: 1-(4-FLUOROPHENYL)-2-(METHYLSULFONYL)-1-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-FLUOROPHENYL)-2-(METHYLSULFONYL)-1-ETHANONE(82652-17-3)
• EPA Substance Registry System: 1-(4-FLUOROPHENYL)-2-(METHYLSULFONYL)-1-ETHANONE(82652-17-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 82652-17-3(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
1-(4-fluorophenyl)-2-(methylsulfonyl)-1-ethanone is used as an intermediate in the synthesis of various organic compounds, leveraging its unique structural features to facilitate the creation of complex molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1-(4-fluorophenyl)-2-(methylsulfonyl)-1-ethanone is used as a key component in the development of new drugs, potentially contributing to the discovery of novel therapeutic agents.

Upstream product

• 58518-77-7 ((1-(4-fluorophenyl)vinyl)oxy)trimethylsilane 
• 124-63-0 methanesulfonyl chloride 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 20277-69-4 sodium methansulfinate 
• 456-04-2 2-Chloro-4'-fluoroacetophenone 
• 405-99-2 para-fluorostyrene 
• 67-68-5 dimethyl sulfoxide 
• 122831-40-7 1-(4-fluorophenyl)-2-(methylthio)ethan-1-one 
• 403-29-2 2-bromo-4'-fluoroacetophenone 
• 67-71-0 dimethylsulfone 
• 403-33-8 methyl 4-flurobenzoate 
• 766-98-3 1-ethynyl-4-fluorobenzene 

Downstream Products

• 1363808-19-8 5-[(2,6-diethyl-4-methylphenyl)carbonyl]-3-(4-fluorophenyl)-1-methyl-4-methylsulfonyl-1H-pyrazole 
• 1363808-15-4 4-(2,6-diethyl-4-methylphenyl)-6-(4-fluorophenyl)-2-methyl-5-methylsulfonyl-2,3-dihydro-3-pyridazinone 

Relevant articles and documents

Copper-catalyzed aerobic oxidative cross-coupling reactions of vinylarenes with sulfinate salts: A direct approach to β-ketosulfones

A copper-catalyzed aerobic oxidative cross-coupling reactions for the synthesis of β-ketosulfones via formation of a C[sbnd]S bond has been demonstrated. Promoted by the crucial copper catalyst, perfect selectivity and good to excellent yields could be achieved. This method, including inexpensive copper catalyst, wide functional group tolerance, and open air conditions, make it very attractive and practical. More importantly, it also provides a versatile tool for the construction of β-ketosulfones from basic starting materials under mild conditions.

Visible-light-promoted aerobic oxidative synthesis of β-ketosulfones under photocatalyst-free conditions

A simple and convenient visible-light-mediated method has been developed for the construction of β-ketosulfones via aerobic oxidative difunctionalization of alkynes with arylazo sulfones and dioxygen in air under photocatalyst-free conditions. The present photochemical methodology provides a facile and attractive protocol to construct a series of β-ketosulfones in moderate to good yields.

Synthesis of β-ketosulfone derivatives as new non-cytotoxic urease inhibitors in vitro

Background: Peptic ulcer and urolithiasis are largely due to infection caused by urease-producing bacteria. Therefore, the discovery of urease inhibitors is an important area of medicinal chemistry research. Objective: The main aim of the work was to identify novel urease inhibitors with no cytotoxicity. Method: During the current study, a series of β-ketosulfones 1-26 was synthesized in two steps and evaluated for their in vitro urease inhibition potential. Results: Out of twenty-six compounds, seventeen have shown good to significant urease inhibitory activity with IC50 values ranging between 49.93-351.46 μM, in comparison to standard thiourea (IC50 = 21 ± 0.11 μM). Moreover, all compounds found to be non-cytotoxic against normal 3T3 cell line. Conclusion: This study has identified β-ketosulfones as novel and non-cytotoxic urease inhibitors.

I2-DMSO-H2O: A Metal-Free Combination System for the Oxidative Addition of Alkynes to Access (E)-α-Iodo-β-methylsulfonylalkenes

A simple and green reaction was discovered for iodization-methylsulfoxidation of alkynes to access (E)-α-iodo-β-methylsulfonylalkenes. This is the first report for the synthesis of iodovinyl methylsulfones by employing alkynes to react with molecular iodi

Preparation method of beta-carbonyl sulfone compound promoted by visible light

The invention discloses a preparation method of a beta-carbonyl sulfone compound promoted by visible light. The preparation method includes the following steps that olefin and aryl-sulphonazo are mixed with an organic solvent and water, and then a reaction is conducted for 16-24 hours at room temperature under visible illumination; and after the reaction, ethyl acetate is used for extracting reaction liquid, and the beta-carbonyl sulfone compound is obtained after concentration and column chromatography isolation of an extract. According to the method, clean light energy is used as reaction energy, oxygen in air is used as an oxidant and an oxygen source, the beta-carbonyl sulfone compound is effectively synthesized at the room temperature, the method does not require any photocatalyst orequivalent inorganic oxidant, and has the advantages of easy and convenient operation, low energy consumption, high reaction safety, environmental friendliness and the like.

Photocatalyst-Free Visible Light-Induced Synthesis of β-Oxo Sulfones via Oxysulfonylation of Alkenes with Arylazo Sulfones and Dioxygen in Air

A catalyst-free strategy has been established for the synthesis of β-oxo sulfones via visible light-induced oxysulfonylation of alkenes with arylazo sulfones with dioxygen in air. The present photoinduced transformation proceeds smoothly at room temperature in the absence of an external photosensitizer, which not only provides a mild and efficient approach to various β-oxo sulfones, but also opens a different reaction mode for the photochemical reaction of arylazo sulfones.

METALLOENZYME INHIBITOR COMPOUNDS

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Nickel-Catalyzed Highly Enantioselective Hydrogenation of β-Acetylamino Vinylsulfones: Access to Chiral β-Amido Sulfones

The nickel/(S)-Binapine complex was found to be an efficient catalyst for asymmetric hydrogenation of β-acetylamino vinylsulfones to afford chiral β-Amido sulfones with excellent yields and enantioselectivities (up to 95% yields and >99% ee). This protocol has good compatibility with a series of substituted (Z)-β-acetylamino vinylsulfones or Z/E isomeric mixtures. A gram-scale reaction has also been achieved in the presence of a 0.2 mol % catalyst loading.

CO/O2 assisted oxidative carbon-carbon and carbon-heteroatom bond cleavage for the synthesis of oxosulfonates from DMSO and olefins

Selective carbon-carbon and carbon-heteroatom bond cleavage was achieved in a one reaction system. With this strategy a novel Pd/Cu-catalyzed aerobic oxidative oxosulfonation of olefins with DMSO has been developed. Preliminary mechanistic investigations indicated that CO/O2 assisted the bond cleavage and the leaving groups from the starting materials were trapped by O2 and underwent a hydroxylation process.

Catalytic and direct methyl sulfonylation of alkenes and alkynes using a methyl sulfonyl radical generated from a DMSO, dioxygen and copper system

This paper describes an efficient method to β-keto methyl sulfones and (E)-vinyl methyl sulfones using DMSO as the substrate. The methyl sulfonyl radical generated from DMSO in the presence of catalytic Cu(i) under O2 atmosphere is believed to be involved in this reaction. Isotopic labeling and 18O2 experiments were performed to investigate the reaction mechanism.