13336-50-0

Basic information

• Product Name: Phosphinic acid, phenyl-, 1-methylethyl ester
• CAS NO: 13336-50-0
• Molecular Formula: C9H13O2P
• Molecular Weight: 184.175
• Mol File: 13336-50-0.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Phosphinic acid, phenyl-, 1-methylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphinic acid, phenyl-, 1-methylethyl ester(13336-50-0)
• EPA Substance Registry System: Phosphinic acid, phenyl-, 1-methylethyl ester(13336-50-0)

Safety Data

• Hazardous Substances Data: 13336-50-0(Hazardous Substances Data)

Upstream product

• 644-97-3 Dichlorophenylphosphine 
• 67-63-0 isopropyl alcohol 
• 36238-99-0 di(isopropyl) phenylphosphonite 
• 628-37-5 diethyl peroxide 
• 85403-92-5 O-isopropylchloro(phenyl)phosphonate 
• 1779-48-2 phenylphosphinic acid 
• 172487-18-2 ethyl Phenylphosphinate 
• 667-27-6 Ethyl bromodifluoroacetate 
• 401-55-8 ethyl bromofluoroacetate 
• 108-23-6 isopropyl chloroformate 
• 1992-48-9 Tetraisopropoxysilan 

Downstream Products

• 130888-91-4 (1-Hydroxy-2-methyl-1H-indol-3-yl)-phenyl-phosphinic acid isopropyl ester 
• 1026133-36-7 isopropyl (2-cyanoethyl)(phenyl)phosphinate 
• 96857-48-6 isopropyl phenylphosphorochloridite 
• 7670-94-2 isopropyl hydrogen phenylphosphonate 
• 7237-16-3 diisopropyl phenylphosphonate 
• 1207477-28-8 N-isobutyl O-isopropyl phenylphosphonic acid amide 
• 1207477-30-2 N-n-butyl O-isopropyl phenylphosphonic acid amide 
• 1161299-55-3 C₁₇H₁₇O₂P 

Relevant articles and documents

Asymmetric synthesis of stereogenic phosphorus P(V) centers using chiral nucleophilic catalysis

Organophosphates have been widely used in agrochemistry, as reagents for organic synthesis, and in biochemistry. Phosphate mimics possessing four unique substituents, and thereby a chirality center, are useful in transition metal catalysis and as nucleotide therapeutics. The catalytic, stereocontrolled synthesis of phosphorus‐stereogenic centers is challenging and traditionally depends on a resolution or use of stochiometric auxiliaries. Herein, enantioenriched phosphorus centers have been synthesized using chiral nucleophilic catalysis. Racemic H‐phosphinate species were coupled with nucleophilic alcohols under halogenating conditions. Chiral phosphonate products were synthesized in acceptable yields (33–95%) and modest enantioselectivity (up to 62% ee) was observed after identification of an appropriate chiral catalyst and optimization of the solvent, base, and temperature. Nucleophilic catalysis has a tremendous potential to produce enantioenriched phosphate mimics that could be used as prodrugs or chemical biology probes.

ROBUST PHOTOCHROMIC COMPOUNDS WITH SILICON- OR PHOSPHORUS-CONTAINING HETEROCYCLIC RING AND PRODUCTION THEREOF

In one embodiment, provided are a new class of diarylethene-containing photochromic compounds with the incorporation of silicon-or phosphorus-containing heterocycles into the "ethene" part of the diarylethene backbone that has been shown to be capable of displaying tunable, robust and thermally stable photochromic properties. Also provided are methods for synthesizing these compounds, as well as uses of these compounds as these compounds may be used as the photochromic layer in an optical recording material and other optical functioning devices.

T3P-assisted esterification and amidation of phosphinic acids

A few phosphinic acids, such as phenylphosphinic acids, 1-hydroxy-3-phospholene 1-oxides and 1-hydroxyphospholane oxides are esterified with simple alcohols in the presence of propylphosphonic anhydride (T3P). If 1.1 equiv of the T3P reagent is used, the esterifications are fast and efficient at 25° C. In the case of more reactive models it was enough to apply 0.66 equiv of T3P at 85°C under microwave conditions. The amidation of 1-hydroxy-3-methyl-3-phospholene oxide could also be accomplished under similar conditions.