15580-32-2

Basic information

• Product Name: 3-ANILINO-3-OXOPROPANOIC ACID
• Synonyms: 3-ANILINO-3-OXOPROPANOIC ACID;3-OXO-3-(PHENYLAMINO)PROPANOIC ACID;PROPANOIC ACID, 3-OXO-3-(PHENYLAMINO)-;RARECHEM AL BO 1122;3-anilino-3-oxopropanoic acid(SALTDATA: FREE);AKOS 215-56
• CAS NO: 15580-32-2
• Molecular Formula: C₉H₉NO₃
• Molecular Weight: 179.17
• Mol File: 15580-32-2.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 456.5 °C at 760 mmHg
• Flash Point: 229.9 °C
• Appearance: liquid
• Density: 1.34 g/cm³
• Vapor Pressure: 3.99E-09mmHg at 25°C
• Refractive Index: 1.616
• CAS DataBase Reference: 3-ANILINO-3-OXOPROPANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ANILINO-3-OXOPROPANOIC ACID(15580-32-2)
• EPA Substance Registry System: 3-ANILINO-3-OXOPROPANOIC ACID(15580-32-2)

Safety Data

• Hazardous Substances Data: 15580-32-2(Hazardous Substances Data)

Usage

Description

3-ANILINO-3-OXOPROPANOIC ACID, also known as 3-Oxo-3-(Phenylamino)propanoic Acid, is an organic compound with the molecular formula C9H9NO3. It is characterized by the presence of an anilinoamino group attached to a 3-oxopropanoic acid backbone. 3-ANILINO-3-OXOPROPANOIC ACID has been identified for its potential applications in various fields, particularly in agriculture.

Uses

Used in Agricultural Industry:
3-ANILINO-3-OXOPROPANOIC ACID is used as a growth regulator and meristem remover for the development of cotton. Its application in this industry is aimed at enhancing the growth and productivity of cotton plants by regulating their growth patterns and removing the meristem, which is the region of undifferentiated cells in the plant responsible for growth and development.

Synthesis Reference(s)

Tetrahedron Letters, 30, p. 3073, 1989 DOI: 10.1016/S0040-4039(00)99406-1

InChI:InChI=1/C9H9NO3/c11-8(6-9(12)13)10-7-4-2-1-3-5-7/h1-5H,6H2,(H,10,11)(H,12,13)

Upstream product

• 16798-45-1 diethyl phenylcarbamoylmalonate 
• 4930-03-4 phenyl N-phenylcarbamate 
• 141-97-9 ethyl acetoacetate 
• 103-84-4 Acetanilid 
• 62-53-3 aniline 
• 105-53-3 diethyl malonate 
• 18629-86-2 2-acetyl-N-phenyl-malonamic acid ethyl ester 
• 102223-21-2 2-benzoyl-N-phenyl-malonamic acid ethyl ester 
• 14438-90-5 N-phenylpropanediamide 
• 2033-24-1 cycl-isopropylidene malonate 
• 1161433-07-3 N-phenyl malonamic acid benzyl ester 
• 103-71-9 phenyl isocyanate 
• 108-88-3 toluene 
• 76311-94-9 Methyl 2-(N-phenylaminocarbonyl)acetate 

Downstream Products

• 27559-50-8 (E)-3-(4-hydroxyphenyl)-N-phenylacrylamide 
• 340258-57-3 (E)-3-(4-methoxyphenyl)-N-phenylacrylamide 
• 100725-94-8 ((Ξ)-furfurylidene)-malonic acid monoanilide 
• 70254-43-2 4-Hydroxy-2-quinolone 
• 40335-02-2 2,3,4-trichloroquinoline 
• 56140-30-8 2-chloro-cinnamic acid anilide 
• 16507-23-6 4,4,4-trichloro-3-hydroxy-butyric acid anilide 
• 27559-49-5 3-(3-hydroxyphenyl)-N-phenyl-2-propenamide 
• 6833-28-9 3ξ-benzo[1,3]dioxol-5-yl-acrylic acid anilide 
• 1161432-99-0 N-phenyl-N'-(quinolin-3-yl)malonamide 
• 1161433-01-7 N-phenyl-N'-(quinolin-8-yl)malonamide 
• 955182-41-9 N-(3-methoxyphenyl)-N'-phenylmalonamide 
• 918628-94-1 N-(2-methoxyphenyl)-N'-phenylmalonamide 
• 1161432-98-9 N-(4-chlorophenyl)-N'-phenylmalonamide 

Relevant articles and documents

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Phosphonate as a Stable Zinc-Binding Group for “Pathoblocker” Inhibitors of Clostridial Collagenase H (ColH)

Microbial infections are a significant threat to public health, and resistance is on the rise, so new antibiotics with novel modes of action are urgently needed. The extracellular zinc metalloprotease collagenase H (ColH) from Clostridium histolyticum is a virulence factor that catalyses tissue damage, leading to improved host invasion and colonisation. Besides the major role of ColH in pathogenicity, its extracellular localisation makes it a highly attractive target for the development of new antivirulence agents. Previously, we had found that a highly selective and potent thiol prodrug (with a hydrolytically cleavable thiocarbamate unit) provided efficient ColH inhibition. We now report the synthesis and biological evaluation of a range of zinc-binding group (ZBG) variants of this thiol-derived inhibitor, with the mercapto unit being replaced by other zinc ligands. Among these, an analogue with a phosphonate motif as ZBG showed promising activity against ColH, an improved selectivity profile, and significantly higher stability than the thiol reference compound, thus making it an attractive candidate for future drug development.

COMPOUND USED AS AUTOPHAGY REGULATOR, AND PREPARATION METHOD THEREFOR AND USES THEREOF

It is related to compounds used as autophagy modulators and a method for preparing and using the same, specifically providing a compound of general formula (I), or pharmaceutically acceptable salts thereof, which is a type of autophagy modulators, particularly mammalian ATG8 homologues modulators.