156-57-0Relevant articles and documents
Method for preparing cysteamine hydrochloride
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Paragraph 0032; 0035-0038, (2020/03/09)
The invention relates to a method for preparing cysteamine hydrochloride. The method comprises the following steps: 1, reacting carbon disulfide with sodium sulfide in alcohol to obtain sodium thiocarbonate; 2, fully reacting 2-aminoethyl sulfate sodium salt or 2-chloroethylamine hydrochloride with the sodium thiocarbonate prepared in the step 1; 3, continuing to add hydrochloric acid for a reaction to obtain first-stage cysteamine hydrochloride mother liquor; 4, cooling and crystallizing the cysteamine hydrochloride mother liquor obtained in the step 3 to crystallize sodium sulfate and/or sodium chloride generated in the reaction in the step 2, and carrying out filtering after crystallization to obtain a filtrate which is second-stage cysteamine hydrochloride mother liquor; 5, carrying out reduced-pressure distillation on the second-stage cysteamine hydrochloride mother liquor obtained in the step 4, and carrying out cooling and crystallizing to obtain a cysteamine hydrochloride solid, wherein a ratio of the 2-aminoethyl sulfate sodium salt to the 2-chloroethylamine hydrochloride is 1: 1. Through further optimization, yield is further increased, and the mass yield can reach 95% interms of sodium sulfide.
Method for synthesizing cysteamine hydrochloride from sodium tetrathiocarbonate
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Paragraph 0030; 0033-0036, (2019/04/17)
Disclosed is a method for synthesizing cysteamine hydrochloride from sodium tetrathiocarbonate. The method comprises the following steps of heating and refluxing carbon disulfide and sodium sulfate solution into a reactor for reaction to obtain sodium tetrathiocarbonate solution; dropwise adding sodium 2-aminoethyl sulfate solution or 2-chloroethylamine hydrochloride with a concentration of 25-30%into the sodium tetrathiocarbonate solution at 40-50 DEG C within 1.5-2.5 h, half an hour later, increasing the temperature to 58-62 DEG C for further reaction unital the sodium tetrathiocarbonate solution turns colorless; adding in hydrochloric acid for reaction, of which the produced carbon disulfide can be recycled; performing reduced-pressure distillation and concentration and then cooled crystallization on the reacted solution to obtain the crystal of sodium sulfate or sodium chloride and the filter liquor of cysteamine hydrochloride aqueous solution; performing reduced-pressure distillation on the cysteamine hydrochloride aqueous solution to remove all water, and then cooling the solids down to obtain the finished cysteamine hydrochloride. The method for synthesizing the cysteaminehydrochloride from the sodium tetrathiocarbonate simplifies the processes and saves the production costs, and the prepared cysteamine hydrochloride is high in yield and purity.
Synthesis of mercaptoethylammonium chloride in alkaline medium
Xiao, Feng,Tan, Shiyu,Zou, Xiaobing
experimental part, p. 3247 - 3248 (2012/08/29)
A new way synthesis of mercaptoethylammonium chloride is reported. Using NaOH replace HCl, the results present that the target product can be made in alkaline medium and the velocity of new way is much faster than the tradition one, which is hydrolyzed at high pressure. 1H NMR and IR characterized the structure of the product.