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19983-15-4

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19983-15-4 Usage

General Description

4,5-dihydro-2-phenylthiazole-4-carboxylic acid is a chemical compound with the molecular formula C10H9NO2S. It is a thiazole derivative with a phenyl group and a carboxylic acid functional group attached to the thiazole ring. 4,5-dihydro-2-phenylthiazole-4-carboxylic acid has potential applications in medicinal chemistry and drug development due to its structural features and potential biological activities. It may also be used as a building block or intermediate in organic synthesis for the preparation of various pharmaceutical compounds. Its unique structure and functional groups make it an interesting target for further research and potential applications in the field of pharmaceuticals and drug discovery.

Check Digit Verification of cas no

The CAS Registry Mumber 19983-15-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,9,8 and 3 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 19983-15:
(7*1)+(6*9)+(5*9)+(4*8)+(3*3)+(2*1)+(1*5)=154
154 % 10 = 4
So 19983-15-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H9NO2S/c12-10(13)8-6-14-9(11-8)7-4-2-1-3-5-7/h1-5,8H,6H2,(H,12,13)

19983-15-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-phenyl-4,5-dihydro-1,3-thiazole-4-carboxylic acid

1.2 Other means of identification

Product number -
Other names 2-phenylthiazoline-4-carboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:19983-15-4 SDS

19983-15-4Relevant articles and documents

Fast and Cysteine-Specific Modification of Peptides, Proteins and Bacteriophage Using Chlorooximes

Chen, Fa-Jie,Zheng, Mengmeng,Nobile, Vincent,Gao, Jianmin

supporting information, (2022/03/15)

This work reports a novel chlorooxime mediated modification of native peptides and proteins under physiologic conditions. This method features fast reaction kinetics (apparent k2=306±4 M?1s?1 for GSH) and exquisite selectivity for cysteine residues. This cysteine conjugation reaction can be carried out with just single-digit micromolar concentrations of the labeling reagent. The conjugates show high stability towards acid, base, and external thiol nucleophiles. A nitrile oxide species generated in situ is likely involved as the key intermediate. Furthermore, a bis-chlorooxime reagent is synthesized to enable facile Cys-Cys stapling in native peptides and proteins. This highly efficient cysteine conjugation and stapling was further implemented on bacteriophage to construct chemically modified phage libraries.

Metabolite profiling reveals a role for intercellular dihydrocamalexic acid in the response of mature Arabidopsis thaliana to Pseudomonas syringae

Kempthorne, Christine J.,Nielsen, Alexander J.,Wilson, Daniel C.,McNulty, James,Cameron, Robin K.,Liscombe, David K.

, (2021/04/12)

The leaf intercellular space is a site of plant-microbe interactions where pathogenic bacteria such as Pseudomonas syringae grow. In Arabidopsis thaliana, the biosynthesis of tryptophan-derived indolic metabolites is induced by P. syringae infection. Using high-resolution mass spectrometry-based profiling and biosynthetic mutants, we investigated the role of indolic compounds and other small molecules in the response of mature Arabidopsis to P. syringae. We observed dihydrocamalexic acid (DHCA), the precursor to the defense-related compound camalexin, accumulating in intercellular washing fluids (IWFs) without further conversion to camalexin. The indolic biosynthesis mutant cyp71a12/cyp71a13 was more susceptible to P. syringae compared to mature wild-type plants displaying age-related resistance (ARR). DHCA and structural analogs inhibit P. syringae growth (MIC ~ 500 μg/mL), but not at concentrations found in IWFs, and DHCA did not inhibit biofilm formation in vitro. However, infiltration of exogenous DHCA enhanced resistance in mature cyp71a12/cyp71a13. These results provide evidence that DHCA derived from CYP71A12 and CYP71A13 activity accumulates in the intercellular space and contributes to the resistance of mature Arabidopsis to P. syringae without directly inhibiting bacterial growth.

Synthesis method of thiazoline heterocyclic compound and application of thiazoline heterocyclic compound in biomolecular modification

-

, (2020/01/12)

The invention discloses a synthesis method of a thiazoline heterocyclic compound and application of the thiazoline heterocyclic compound in biomolecular modification, and relates to the technical field of organic synthesis. The synthesis method comprises the following steps: mixing a thioalkene ether compound and a compound containing a 1, 2-mercaptoethylamine skeleton structure in a solvent, andadding a weak base to react for 60-240 minutes at the reaction temperature of 20-60 DEG C to obtain the dihydrothiazole heterocyclic compound. The synthesis method of the thiazolidine heterocyclic compound is mild and efficient, can quickly react in water at room temperature, and overcomes the defects of violent reaction conditions, long reaction time and the like in the traditional synthetic method; by means of the synthesis method, biomolecules such as polypeptide and protein containing the nitrogen-terminal cysteine residues can be efficiently and accurately modified, and application of detection and treatment methods and the like is further developed.

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