2476-35-9

Basic information

• Product Name: 5-Bromo-2-methoxybenzoic acid
• Synonyms: RARECHEM AL BE 0053;2-METHOXY-5-BROMOBENZOIC ACID;5-BROMO-2-METHOXYBENZOIC ACID;5-BROMO-O-ANISIC ACID;AKOS BBB/391;AKOS BB-8176;AKOS B025214;ASISCHEM Y08619
• CAS NO: 2476-35-9
• Molecular Formula: C₈H₇BrO₃
• Molecular Weight: 231.04
• Product Categories: Benzoic acid;Acids & Esters;Anisoles, Alkyloxy Compounds & Phenylacetates;Bromine Compounds;C8;Carbonyl Compounds;Carboxylic Acids
• Mol File: 2476-35-9.mol

Chemical Properties

• Melting Point: 118-122 °C
• Boiling Point: 334.7 °C at 760 mmHg
• Flash Point: 156.2 °C
• Appearance: /
• Density: 1.625 g/cm³
• Vapor Pressure: 4.97E-05mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.70±0.10(Predicted)
• CAS DataBase Reference: 5-Bromo-2-methoxybenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-2-methoxybenzoic acid(2476-35-9)
• EPA Substance Registry System: 5-Bromo-2-methoxybenzoic acid(2476-35-9)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 2476-35-9(Hazardous Substances Data)

Usage

Chemical Properties

off-white powder

Synthesis Reference(s)

Tetrahedron Letters, 34, p. 931, 1993 DOI: 10.1016/S0040-4039(00)77457-0

InChI:InChI=1/C8H7BrO3/c1-12-7-3-2-5(9)4-6(7)8(10)11/h2-4H,1H3,(H,10,11)/p-1

Upstream product

• 109-72-8 n-butyllithium 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 60-29-7 diethyl ether 
• 917-54-4 methyllithium 
• 7017-52-9 4-bromo-2-(chloromethyl)-1-methoxybenzene 
• 579-75-9 2-Methoxybenzoic acid 
• 124-38-9 carbon dioxide 
• 7732-18-5 water 
• 7726-95-6 bromine 
• 64-19-7 acetic acid 
• 14804-31-0 2-methyl-4-bromoanisole 
• 7664-93-9 sulfuric acid 
• 163260-76-2 4-bromo-2-(2-bromo-ethyl)-anisole 
• 861362-94-9 2-bromo-3-(5-bromo-2-methoxy-phenyl)-3-hydroxy-propionic acid 

Downstream Products

• 99-58-1 3-bromo-4-methoxybenzoic acid 
• 773134-60-4 ethyl 5-bromo-2-methoxybenzoate 
• 40394-06-7 Methyl-3-troponyl-6-methoxybenzoat 
• 106-41-2 4-bromo-phenol 
• 95-56-7 2-hydroxybromobenzene 
• 13130-23-9 3,5-dibromo-2-methoxybenzoic acid 
• 107410-07-1 2-methoxy-5-phenylbenzoic acid 
• 60541-89-1 5-bromo-2-methoxy-3-nitro-benzoic acid 
• 55082-33-2 5-bromo-2-hydroxybenzophenone 
• 453566-34-2 3-(pyridin-2-yl)-5-(5-bromo-2-methoxyphenyl)-1,2,4-oxadiazole 
• 959748-97-1 5-bromo-N-[(2Z)-5-tert-butyl-3-[(2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-methoxybenzamide 
• 303111-31-1 2-methoxy-5-bromobenzene carboxamide 
• 1424432-41-6 2-methoxy-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide 
• 98273-59-7 4-bromo-2-iodo-anisole 

Relevant articles and documents

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A convenient and efficient H2SO4-promoted regioselective monobromination of phenol derivatives using N-bromosuccinimide

A convenient, rapid H2SO4-promoted regioselective monobromination reaction with N-bromosuccinimide was developed. The desired para-monobrominated or ortho-monobrominated products of phenol derivatives were obtained in good to excellent yields with high selectivity. Regioselective chlorination and iodination were also achieved in the presence of H2SO4 using N-chlorosuccinimide and N-iodosuccinimide, respectively.

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Transition-metal-free decarboxylative bromination of aromatic carboxylic acids

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