31127-80-7Relevant articles and documents
Preparation method of iodixanol hydrolysate
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Page/Page column 0042-0052, (2020/09/12)
The invention discloses a preparation method of an iodixanol hydrolysate. The preparation method comprises the following steps: in ionic liquid, condensing and hydrolyzing 5-acetamido-2,4,6-triiodo-1,3-benzenedicarboxamide and epoxy chloropropane under the action of a solid base catalyst to obtain the product 5-(acetamido)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide, wherein the solid base catalyst takes a metal oxide as a first active component, takes one or more of corresponding metal hydroxide, carbonate and bicarbonate as a second active component, and takes strongly basic anion exchange resin as a carrier. The catalyst is simple in preparation process, good in activity, long in service cycle, high in product yield, good in purity and free of trace impurities limited by drugs. Equipment is not corroded in the production process, product post-treatment is convenient, the production cost is low, and the method is economical, practical, green and environmentally friendly.
Novel energy-saving environment-friendly continuous preparation method of iohexol
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Paragraph 0033; 0043; 0047, (2018/07/28)
The invention relates to a novel energy-saving environment-friendly continuous preparation method of iohexol. The preparation method specifically comprises the following steps: (1) acylation reaction:carrying out a reaction on a compound of a formula [2] with acetic anhydride in an environment of hydrochloric acid to obtain a compound of a formula [3]; (2) transesterification: carrying out a reaction on the compound of the formula [3] with a small-molecule liquid alcohol under an appropriate condition to obtain a compound of a formula [4], (3) alkylation reaction: carrying out a reaction on the compound of the formula [4] with 3-chloro-1,2-propylene glycol under the condition of a mixed solution of methanol and sodium methoxide, carrying out neutralization, filtering and desolvation to obtain an iohexol crude product; (4) purification: purifying the iohexol crude product to obtain an iohexol pure product. The method comprises carrying out the transesterification reaction on the liquidalcohol with 5-acetylamino-2,4,6-triiodo-N,N'-bis(2,3-diacetoxypropyl)-1,3-phthalamide, then carrying out an alkylation reaction with the alkylating reagent 3-chloro-1,2-propylene glycol in a methanol solution of the sodium methoxide, carrying out neutralization by using a methanol solution of hydrochloric acid, carrying out filtering, carrying out desolvation on the obtained filtrate, and thenpurifying the obtained iohexol crude product to obtain the iohexol pure product.
MECHANOCHEMICAL SYNTHESIS OF RADIOGRAPHIC AGENTS INTERMEDIATES
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Page/Page column 27, (2018/06/30)
The present invention generally relates to a process using a mechanochemical approach exploiting the mechanical milling of reactants for the manufacturing of acetyl Iopamidol and, more generally, of key intermediates of radiographic contrast agents, and of the contrast agents themselves.