36942-56-0Relevant articles and documents
Magnolol dimer-derived fragments as PPARγ-selective probes
Dreier, Dominik,Resetar, Mirta,Temml, Veronika,Rycek, Lukas,Kratena, Nicolas,Schnürch, Michael,Schuster, Daniela,Dirsch, Verena M.,Mihovilovic, Marko D.
, p. 7019 - 7028 (2018)
Partial agonists of the transcription factor PPARγ (peroxisome proliferator-activated receptor γ) have shown potential for the treatment of metabolic and inflammatory conditions and novel activators serve as valuable tool and lead compounds. Based on the
ENANTIOPURE TERPHENYLS WITH TWO ORTHO-ATROPISOMERIC AXES
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Page/Page column 18-19, (2019/07/19)
Enantiopure terphenyl presenting two ortho-located chiral axes having the following structural formula (I) : their process of synthesis and their use as mono or bidentate ligands for asymmetric organometallic reactions, as organocatalysts, as chiral base
Fast and Tight Boronate Formation for Click Bioorthogonal Conjugation
Akgun, Burcin,Hall, Dennis G.
supporting information, p. 3909 - 3913 (2016/03/19)
A new click bioorthogonal reaction system was devised to enable the fast ligation (kON≈340 m-1 s-1) of conjugatable derivatives of a rigid cyclic diol (nopoldiol) and a carefully optimized boronic acid partner, 2-methyl-5-carboxymethylphenylboronic acid. Using NMR and fluorescence spectroscopy studies, the corresponding boronates were found to form reversibly within minutes at low micromolar concentration in water, providing submicromolar equilibrium constant (Keq≈105-106 m-1). Efficient protein conjugation under physiological conditions was demonstrated with model proteins thioredoxin and albumin, and characterized by mass spectrometry and gel electrophoresis.