4013-72-3

Basic information

• Product Name: NICOTINOYL AZIDE
• Synonyms: NICOTINOYL AZIDE;3-Pyridinecarboxylic acid azide;Nicotinic acid azide;3-Pyridinecarbonyl azide;Nicotinoyl azide ,98%
• CAS NO: 4013-72-3
• Molecular Formula: C₆H₄N₄O
• Molecular Weight: 148.12
• Mol File: 4013-72-3.mol
• Article Data: 34

Chemical Properties

• Appearance: /
• CAS DataBase Reference: NICOTINOYL AZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: NICOTINOYL AZIDE(4013-72-3)
• EPA Substance Registry System: NICOTINOYL AZIDE(4013-72-3)

Safety Data

• Hazardous Substances Data: 4013-72-3(Hazardous Substances Data)

Usage

General Description

Nicotinoyl azide is a chemical compound primarily used in laboratory settings. Due to the nature of azides, it carries energetic and potentially explosive properties. Although its exact applications are not abundantly discussed in literature, it's likely used in organic synthesis processes as a niche reagent. Like with all azides, careful handling procedures are necessary to prevent dangerous reactions including explosion. Its systematic name is pyridine-3-carboxylic acid azide.

InChI:InChI=1/C6H4N4O/c7-10-9-6(11)5-2-1-3-8-4-5/h1-4H

Upstream product

• 59-67-6 nicotinic acid 
• 500-22-1 3-pyridinecarboxaldehyde 
• 10400-19-8 3-pyridinecarbonyl chloride 
• 1120-90-7 3-iodopyridine 
• 50-00-0 formaldehyd 
• 201230-82-2 carbon monoxide 
• 144223-30-3 (1H-benzo[d][1,2,3]triazol-1-yl)(pyridin-3-yl)methanone 
• 20260-53-1 pyridine-3-carbonyl chloride hydrochloride 
• 98277-31-7 nicotinoylsemicarbazide 
• 553-53-7 Nicotinic acid hydrazide 
• 98-92-0 nicotinamide 

Downstream Products

• 17274-89-4 (S)-2-(nicotinamido)-3-phenylpropanoic acid 
• 304509-94-2 1,1′-(1,3-phenylene)bis(3-(pyridin-3-yl)urea) 
• 1043876-34-1 1,1′-(1,4-phenylene)bis(3-(pyridin-3-yl)urea) 
• 1430116-32-7 N-(3-pyridyl),N′-(pentafluorophenyl)urea 
• 7376-96-7 N-nicotinoyl-L-tyrosin-amide 
• 7376-91-2 N-nicotinoyl-DL-phenylalanin-amide 
• 73976-65-5 N-[(S)-1-((S)-1-Hydrazinocarbonyl-3-methyl-butylcarbamoyl)-2-phenyl-ethyl]-nicotinamide 
• 73976-70-2 N-((S)-1-{(S)-1-[1-(4-Hydroxy-phenyl)-meth-(E)-ylidene-hydrazinocarbonyl]-3-methyl-butylcarbamoyl}-3-methylsulfanyl-propyl)-nicotinamide 

Relevant articles and documents

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Assaying RNA solvent accessibility in living cells with LASER

RNA molecules perform a wide variety of functions to control many cellular pathways. Critical to these roles is the ability of an RNA to fold into complex three-dimensional structures. As part of this folding, unique elements of RNA structure become more exposed or hidden to solvent and these properties are important to understand an RNAs final fold. Characterizing solvent accessibility can enable researchers to better understand the overall fold of an RNA and how it interacts with trans acting factors, such as proteins. Herein we describe the methods toward using light activated structural evaluation of RNA, or LASER, which measures purine nucleobase solvent accessibility. To date, LASER has been used inside and outside of cells to measure RNA solvent accessibility and RNA interactions with proteins.

Synthesis of: N -methylated amines from acyl azides using methanol

The transformation of acyl azide derivatives into N-methylamines was developed using methanol as the C1 source via the one-pot Curtius rearrangement and borrowing hydrogen methodology. Following this protocol, various functionalised N-methylated amines were synthesized using the (NNN)Ru(ii) complex from carboxylic acids via an acyl azide intermediate. Several kinetic studies and DFT calculations were carried out to support the mechanism and also to determine the role of the Ru(ii) complex and base in this transformation.