Welcome to LookChem.com Sign In|Join Free

Cas Database

42206-94-0

42206-94-0

Identification

  • Product Name:Acetyl trans-resveratrol

  • CAS Number: 42206-94-0

  • EINECS:

  • Molecular Weight:354.359

  • Molecular Formula: C20H18O6

  • HS Code:2918990090

  • Mol File:42206-94-0.mol

Synonyms:1,3-Benzenediol,5-[(1E)-2-[4-(acetyloxy)phenyl]ethenyl]-, diacetate (9CI);1,3-Benzenediol,5-[2-[4-(acetyloxy)phenyl]ethenyl]-, diacetate, (E)-;3,4',5-Triacetoxy-trans-stilbene;3,5,4'-Tri-O-acetylresveratrol;trans-Resveratrol triacetate;

Post Buying Request Now
Entrust LookChem procurement to find high-quality suppliers faster

Safety information and MSDS view more

  • Hazard Codes:Xi,N

  • Signal Word:Danger

  • Hazard Statement:H315 Causes skin irritationH317 May cause an allergic skin reaction H318 Causes serious eye damage H335 May cause respiratory irritation H400 Very toxic to aquatic life

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:Usbiological
  • Product Description:trans-Resveratrol Triacetate
  • Packaging:50mg
  • Price:$ 446
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TCI Chemical
  • Product Description:Triacetyl resveratrol >98.0%(GC)
  • Packaging:5g
  • Price:$ 38
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TCI Chemical
  • Product Description:Triacetyl resveratrol >98.0%(GC)
  • Packaging:1g
  • Price:$ 13
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:4-[(E)-2-(3,5-Diacetoxyphenyl)vinyl]phenyl acetate 98.0%
  • Packaging:25 g
  • Price:$ 109
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:4-[(E)-2-(3,5-Diacetoxyphenyl)vinyl]phenyl acetate 98.0%
  • Packaging:1 g
  • Price:$ 24
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:4-[(E)-2-(3,5-Diacetoxyphenyl)vinyl]phenyl acetate 98.0%
  • Packaging:5 g
  • Price:$ 47
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Triacetyl resveratrol ≥98% (HPLC)
  • Packaging:10mg
  • Price:$ 83.9
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Resveratrol, Triacetyl
  • Packaging:25mg
  • Price:$ 164
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Triacetyl resveratrol ≥98% (HPLC)
  • Packaging:50mg
  • Price:$ 329
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Medical Isotopes, Inc.
  • Product Description:trans-ResveratrolTriacetate
  • Packaging:500 mg
  • Price:$ 2120
  • Delivery:In stock
  • Buy Now

Relevant articles and documentsAll total 26 Articles be found

Immobilized Lipase Based on Hollow Mesoporous Silicon Spheres for Efficient Enzymatic Synthesis of Resveratrol Ester Derivatives

Xu, Liu-Jia,Yang, Tao,Wang, Jing,Huang, Feng-Hong,Zheng, Ming-Ming

, p. 9067 - 9075 (2021/03/01)

Enzymatic esterification of resveratrol is crucial for its potential application in lipophilic foods and drugs. However, the poor activity of the free enzyme hinders the reaction. In this work, the highly efficient enzymatic synthesis of resveratrol ester derivatives was achieved by immobilized lipase on hydrophobic modified hollow mesoporous silicon spheres (HMSS-C8). We preliminarily explored the use of Candida sp. 99-125 lipase (CSL) for the acylation of resveratrol, with a regioselectivity toward 3-OH- over 4'-OH-acylation. HMSS-C8 provided ideal accommodation for CSL with a loading capacity of up to 652 mg/g. The catalytic efficiency of CSL@HMSS-C8 was 15 times higher than that of free CSL, and the conversion of resveratrol reached 98.7% within only 2 h, which is the fastest value recorded in the current literature. After 10 cycles, the conversion remained up to 86.3%. Benefiting from better lipid solubility, the relative oxidation stability index values of oil containing monoester derivatives were 43.1%-68.8% and 23.9%-33.2% higher than that of refined oil and oil containing resveratrol, respectively. This research provides a new pathway for efficient enzymatic synthesis of resveratrol ester derivatives and demonstrates the potential application of resveratrol monoester derivatives as a group of excellent lipid-soluble antioxidants.

Photochemically Induced Solid State Dimerisation of Resveratrol Analogues: A Greener Synthetic Process

Danylec, Basil,Campi, Eva M.,Forsyth, Craig M.,Boysen, Reinhard I.,Hearn, Milton T. W.

, p. 1260 - 1270 (2020/10/06)

The photochemical dimerisation of resveratrol analogues in the solid state to generate chiral phenyl substituted cyclobutanes is described. NMR spectroscopic and X-ray crystallographic methods have confirmed that the dimerisation leads to the head to tail orientation of the phenyl group substituents in the cyclobutane derivative. Interestingly, the parent compound, resveratrol, in the solid state, did not form a cyclobutane dimer, but the O-acetyl analogues gave the corresponding cyclobutane dimers in high yield, suggesting that the close packing of molecules together with the electron density through the conjugated double bond of the resveratrol structure are important determinants for photodimerisation to occur in the solid state.

Effective Sample Preparation of Polyphenols in Wine Using Deep Eutectic Solvent-based Dispersive Liquid–Liquid Microextraction HPLC-UV Determination

Noh, Jongsung,Song, Seunghoon,Myung, Seung-Woon

, p. 1175 - 1183 (2020/10/28)

Polyphenols are phytochemicals that exist in grapes and are beneficial to human health. In this study, resveratrol, oxyresveratrol, and piceatannol in wine were extracted by deep eutectic solvent dispersive liquid–liquid microextraction (DES-DLLME), and a method was established for quantifying these polyphenols by high-performance liquid chromatography-UV/Vis (HPLC-UV/Vis). Several parameters pertaining to sample extraction, clean-up, and concentration were optimized and verified with central composite design (CCD) using Design Expert 11. The optimized sample preparation parameters are as follows: the DES extraction solvent, tributylmethylammonium chloride/decanoic acid (1:3 M ratio); basic solvent, 1.3 mL of 5% potassium bicarbonate; volume of acetic anhydride, 250 μL; derivatization time, 5 min; dispersive solvent, methanol; ratio of extraction and dispersive solvents, 1:5.5; and salt, 1.0 g. Chromatographic separation by HPLC/UV–Vis was performed on an ACME C18 (4.6 mm id × 150 mm length, 5 μm particle size) column in gradient elution mode using water and 70% methanol. Under the established extraction and HPLC-UV conditions, the limit of detection (LOD) and limit of quantitation (LOQ) of the three analytes in spiked samples ranged from 1.69 to 2.53 μg/L and 5.64 to 8.42 μg/L, respectively. Recovery studies were performed in low, medium, and high concentration ranges to establish a calibration curve, and the accuracy and precision in the working range were 95.1–108.0% and 1.3–6.7 RSD%, respectively. The calibration curves for quantitative analysis were obtained in the concentration ranges 5.6–56.4, 8.3–82.6, and 8.4–84.2 μg/L, with correlation coefficients (r2) ranging from 0.9947 to 0.9967. The proposed method was applied to the determination of polyphenols in wine samples.

Resveratrol triacetate continuous preparation method (by machine translation)

-

Paragraph 0018-0039, (2019/03/08)

The invention discloses a resveratrol triacetate continuous preparation method. The resveratrol and sodium hydroxide into water, and then the micro-reactor in acetic anhydride esterification reaction, resveratrol [...] obtained after separation and purification. The present invention uses advanced continuous micro-reaction technology, simple and convenient operation, high efficiency, short reaction time, good selectivity, high product yield, the abolishment of the traditional used in the preparation method of the triethylamine, pyridine, dimethylamino pyridine organic alkali, for environmental protection. (by machine translation)

Inhibition of Pancreatic α-amylase by Resveratrol Derivatives: Biological activity and molecular modelling evidence for cooperativity between viniferin enantiomers

Mattio, Luce M.,Marengo, Mauro,Parravicini, Chiara,Eberini, Ivano,Dallavalle, Sabrina,Bonomi, Francesco,Iametti, Stefania,Pinto, Andrea

, (2019/09/09)

To improve the current understanding of the role of stilbenoids in the management of diabetes, the inhibition of the pancreatic α-amylase by resveratrol derivatives was investigated. To approach in a systematic way, the mechanistic and structural aspects of the interaction, potential bioactive agents were prepared as single molecules, that were used for the biological evaluation of the determinants of inhibitory binding. Some dimeric stilbenoids—in particular, viniferin isomers— were found to be better than the reference drug acarbose in inhibiting the pancreatic α-amylase. Racemic mixtures of viniferins were more effective inhibitors than the respective isolated pure enantiomers at an equivalent total concentration, and displayed cooperative effects not observed with the individual enantiomers. The molecular docking analysis provided a thermodynamics-based rationale for the measured inhibitory ability and for the observed synergistic effects. Indeed, the binding of additional ligands on the surface of the alpha-amylase was found to decrease the dissociation constant of inhibitors bound to the active site of the enzyme, thus providing a mechanistic rationale for the observed inhibitory synergies.

Process route upstream and downstream products

Process route

(E)-5-[2-4-(hydroxyphenyl)ethenyl]-1,3-benzenediol
501-36-0

(E)-5-[2-4-(hydroxyphenyl)ethenyl]-1,3-benzenediol

acetyl chloride
75-36-5

acetyl chloride

triacetyl-trans-resveratrol
42206-94-0

triacetyl-trans-resveratrol

Conditions
Conditions Yield
(E)-5-[2-4-(hydroxyphenyl)ethenyl]-1,3-benzenediol; With dmap; triethylamine; In dichloromethane; at 10 ℃;
acetyl chloride; In dichloromethane; at 10 ℃; for 1h;
88.2%
With pyridine; In dichloromethane; at 20 ℃;
4-bromophenyl acetate
1927-95-3

4-bromophenyl acetate

5-vinyl-1,3-phenylene diacetate
155222-48-3

5-vinyl-1,3-phenylene diacetate

triacetyl-trans-resveratrol
42206-94-0

triacetyl-trans-resveratrol

Conditions
Conditions Yield
With potassium carbonate; acetophenon-oxim derived palladium catalyst (CAS No. 32679-19-9); In 1-methyl-pyrrolidin-2-one; at 150 ℃; for 3h; Product distribution / selectivity;
94%
With tetrabutyl-ammonium chloride; sodium hydrogencarbonate; palladium diacetate; In DMF (N,N-dimethyl-formamide); at 100 ℃; for 3h; Product distribution / selectivity;
4-bromophenyl acetate
1927-95-3

4-bromophenyl acetate

acetic anhydride
108-24-7

acetic anhydride

5-vinyl-1,3-phenylene diacetate
155222-48-3

5-vinyl-1,3-phenylene diacetate

triacetyl-trans-resveratrol
42206-94-0

triacetyl-trans-resveratrol

Conditions
Conditions Yield
4-bromophenyl acetate; 5-vinyl-1,3-phenylene diacetate; With sodium hydrogencarbonate; palladium diacetate; tris-(o-tolyl)phosphine; In DMF (N,N-dimethyl-formamide); at 100 ℃; for 18h;
acetic anhydride; With pyridine; In ethyl acetate; at 80 ℃; for 1h; Product distribution / selectivity;
75%
p-acetoxystyrene
2628-16-2

p-acetoxystyrene

3,5-diacetoxybenzoic acid, N,N-DMF and thionyl chloride

3,5-diacetoxybenzoic acid, N,N-DMF and thionyl chloride

triacetyl-trans-resveratrol
42206-94-0

triacetyl-trans-resveratrol

Conditions
Conditions Yield
With N-ethylmorpholine;; palladium diacetate; In hexane; ethyl acetate; toluene;
4-acetoxyiodobenzene
33527-94-5

4-acetoxyiodobenzene

5-vinyl-1,3-phenylene diacetate
155222-48-3

5-vinyl-1,3-phenylene diacetate

triacetyl-trans-resveratrol
42206-94-0

triacetyl-trans-resveratrol

Conditions
Conditions Yield
With triethylamine; triphenylphosphine; palladium diacetate; In acetonitrile; at 85 ℃; for 17h;
70%
p-acetoxystyrene
2628-16-2

p-acetoxystyrene

3,5-diacetoxybenzoic acid
35354-29-1

3,5-diacetoxybenzoic acid

triacetyl-trans-resveratrol
42206-94-0

triacetyl-trans-resveratrol

Conditions
Conditions Yield
With N-ethylmorpholine;; thionyl chloride; palladium diacetate; In ethyl acetate; N,N-dimethyl-formamide; toluene;
3,5-diacetoxybromobenzene

3,5-diacetoxybromobenzene

p-acetoxystyrene
2628-16-2

p-acetoxystyrene

triacetyl-trans-resveratrol
42206-94-0

triacetyl-trans-resveratrol

Conditions
Conditions Yield
With potassium carbonate; acetophenon-oxim derived palladium catalyst (CAS No. 32679-19-9); In DMF (N,N-dimethyl-formamide); at 150 ℃; for 15h; Product distribution / selectivity;
3,5-Dihydroxybenzoic acid
99-10-5

3,5-Dihydroxybenzoic acid

triacetyl-trans-resveratrol
42206-94-0

triacetyl-trans-resveratrol

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: 90 percent / pyridine
2: 94 percent / oxalyl chloride; DMF
3: 73 percent / N-ethylmorpholine; N,N-bis-(2,6-diisopropyl)dihydroimidazolium chloride; Pd(OAc)2 / xylene / 3.5 h / 120 °C
With N-ethylmorpholine;; pyridine; palladium diacetate; oxalyl dichloride; N,N-dimethyl-formamide; 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride; In xylene; 3: decarbonylative Heck reaction;
Multi-step reaction with 3 steps
1: 90 percent / pyridine
2: 92 percent / Et3N
3: 20 percent / N-methylmorpholine; N,N-bis-(2,6-diisopropyl)dihydroimidazolium chloride; Pd(OAc)2 / xylene / 120 °C
With 4-methyl-morpholine; pyridine; palladium diacetate; triethylamine; 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride; In xylene; 3: decarbonylative Heck reaction;
Multi-step reaction with 2 steps
1: dmap; acetic anhydride; sodium hydrogencarbonate; pyridine; formic acid / ethyl acetate; water
2: thionyl chloride; N-ethylmorpholine; / palladium diacetate / ethyl acetate; N,N-dimethyl-formamide; toluene
With N-ethylmorpholine;; pyridine; dmap; formic acid; thionyl chloride; acetic anhydride; sodium hydrogencarbonate; palladium diacetate; In water; ethyl acetate; N,N-dimethyl-formamide; toluene;
Multi-step reaction with 3 steps
1: pyridine; dmap / ethyl acetate / 0 - 20 °C
2: thionyl chloride / toluene; N,N-dimethyl-formamide / 3 h / 100 °C / Inert atmosphere
3: N-ethylmorpholine;; palladium diacetate / toluene / Reflux
With N-ethylmorpholine;; pyridine; dmap; thionyl chloride; palladium diacetate; In ethyl acetate; N,N-dimethyl-formamide; toluene;
4-chlorophenyl acetate
876-27-7

4-chlorophenyl acetate

5-vinyl-1,3-phenylene diacetate
155222-48-3

5-vinyl-1,3-phenylene diacetate

triacetyl-trans-resveratrol
42206-94-0

triacetyl-trans-resveratrol

Conditions
Conditions Yield
With potassium phosphate; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; catacxium A; at 120 ℃; for 15.5h; Product distribution / selectivity;
With caesium carbonate; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; tri-tert-butyl phosphine; at 120 ℃; for 19h; Product distribution / selectivity;
p-acetoxystyrene
2628-16-2

p-acetoxystyrene

C<sub>16</sub>H<sub>18</sub>O<sub>7</sub>
593249-77-5

C16H18O7

triacetyl-trans-resveratrol
42206-94-0

triacetyl-trans-resveratrol

Conditions
Conditions Yield
With 4-methyl-morpholine; palladium diacetate; 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride; In xylene; at 120 ℃;
20%

Global suppliers and manufacturers

Global( 130) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • Simagchem Corporation
  • Business Type:Manufacturers
  • Contact Tel:+86-592-2680277
  • Emails:sale@simagchem.com
  • Main Products:110
  • Country:China (Mainland)
  • EAST CHEMSOURCES LIMITED
  • Business Type:Manufacturers
  • Contact Tel:86-532-81906761
  • Emails:josen@eastchem-cn.com
  • Main Products:97
  • Country:China (Mainland)
  • Amadis Chemical Co., Ltd.
  • Business Type:Lab/Research institutions
  • Contact Tel:86-571-89925085
  • Emails:sales@amadischem.com
  • Main Products:29
  • Country:China (Mainland)
  • Chemwill Asia Co., Ltd.
  • Business Type:Manufacturers
  • Contact Tel:021-51086038
  • Emails:chemwill_asia@126.com
  • Main Products:130
  • Country:China (Mainland)
  • LIDE PHARMACEUTICALS LIMITED
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-25-58409506
  • Emails:lide@lidepharma.com
  • Main Products:56
  • Country:China (Mainland)
  • Shanghai Upbio Tech Co.,Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-21-52196435
  • Emails:upbiocn@hotmail.com
  • Main Products:88
  • Country:China (Mainland)
  • Wuhan Wonda Pharm Limited
  • Business Type:Lab/Research institutions
  • Contact Tel:027-84306245
  • Emails:wonda-chem@outlook.com
  • Main Products:30
  • Country:China (Mainland)
close

Please post your buying leads,so that our qualified suppliers will soon contact you!

*Required Fields

CAS No.:
* Product Name:
* Your email:

Your email will be used to sign-in to LookChem.com
* Requirements:
* Valid for:
 
Post Buying Request Now
close
Remarks: The blank with*must be completed