4492-01-7

Basic information

• Product Name: 1,3-DIPHENYL-1H-PYRAZOLE
• Synonyms: 1,3-DIPHENYL-1H-PYRAZOLE
• CAS NO: 4492-01-7
• Molecular Formula: C₁₅H₁₂N₂
• Molecular Weight: 220.27
• Product Categories: pharmacetical
• Mol File: 4492-01-7.mol
• Article Data: 47

Chemical Properties

• Melting Point: 85.8°C
• Boiling Point: 351.21°C (rough estimate)
• Flash Point: 181.8°C
• Appearance: /
• Density: 1.0794
• Vapor Pressure: 1.51E-05mmHg at 25°C
• Refractive Index: 1.5000 (estimate)
• CAS DataBase Reference: 1,3-DIPHENYL-1H-PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-DIPHENYL-1H-PYRAZOLE(4492-01-7)
• EPA Substance Registry System: 1,3-DIPHENYL-1H-PYRAZOLE(4492-01-7)

Safety Data

• Hazardous Substances Data: 4492-01-7(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthetic Communications, 6, p. 5, 1976 DOI: 10.1080/00397917608062125

InChI:InChI=1/C15H12N2/c1-3-7-13(8-4-1)15-11-12-17(16-15)14-9-5-2-6-10-14/h1-12H

Upstream product

• 931-55-5 phenyl-diazene 
• 1190837-93-4 1-phenyl-1H-pyrazol-3-yl trifluoromethane sulfonate 
• 98-80-6 phenylboronic acid 
• 66040-87-7 1,3-diphenyl-5-(methylthio)-1H-pyrazole 
• 52179-65-4 2(formyl-N-phenylimine)-3-phenyl-2H-azirine 
• 57623-18-4 1-phenyl-3-(N-phenyl-hydrazino)-propenone 
• 71-43-2 benzene 
• 67-64-1 acetone 
• 141-78-6 ethyl acetate 
• 7647-01-0 hydrogenchloride 
• 57623-19-5 formic acid-[N'-(3-oxo-3-phenyl-propenyl)-N'-phenyl-hydrazide] 
• 60-29-7 diethyl ether 
• 57623-20-8 3-benzoyloxy-1-phenyl-propenone 
• 100-63-0 phenylhydrazine 

Downstream Products

• 17647-21-1 1,3-diphenyl-1H-pyrazole-4-carbonitrile 
• 21487-45-6 1,3-diphenyl-4-formylpyrazole 
• 92438-75-0 1,3-bis-(4-nitro-phenyl)-1H-pyrazole 
• 4847-47-6 β-(phenylamino)-cinnamic acid nitrile 
• 2538-52-5 1,3-diphenyl-4,5-dihydro-1H-pyrazole 

Relevant articles and documents

Thermal cyclization of 3-(1-naphthyl)-1-phenylpyrazole- 4-carboxylic acid in polyphosphoric acid [12]

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Primary Vinyl Ethers as Acetylene Surrogate: A Flexible Tool for Deuterium-Labeled Pyrazole Synthesis

A novel synthetic path to 1,3-disubstituted pyrazoles and their deuterated derivatives was developed. It is based on the reaction of vinyl ethers with hydrazonoyl chlorides in the presence of triethylamine. The reaction mechanism, clarified by the joint experimental and computational study, involves 1,3-dipolar cycloaddition of the in situ generated nitrile imines to vinyl ethers and subsequent cleavage of alcohol from the formed alkoxypyrazoline. The results highlight the possibility of using vinyl ethers as acetylene surrogate and provide a novel access to pyrazoles, 4,5-dideuteropyrazoles and their regioselectively labeled derivatives, 5-deuteropyrazoles.

Ruthenium-catalyzed formation of pyrazoles or 3-hydroxynitriles from propargyl alcohols and hydrazines

Functionalized pyrazoles are generated from secondary propragyl alcohols and hydrazines in a ruthenium-catalyzed cascade process, consisting of redox isomerization, Michael addition, cyclocondensation and dehydrogenation steps. The same bifunctional catalyst mediates the conversion of tertiary propargyl alcohols with hydrazine to 3-hydroxynitriles via anti-Markovnikov hydroamination followed by elimination of ammonia.

Facile synthesis of pyrazoles by iron-catalyzed regioselective cyclization of hydrazone and 1,2-diol under ligand-free conditions

A facile synthesis of pyrazoles by the cyclization of hydrazones and 1,2-diols was described. In the presence of ferric nitrate, the reaction occurs under neat conditions and makes the use of potassium persulfate to oxidize the diol to α-hydroxy carbaldehyde for the reaction with hydrazones to produce 1,3- and 1,3,5-substituted pyrazoles selectively. The overall regioselective transformation occurs in one-pot under ligand-free, mild conditions even in the presence of air.