4750-28-1

Basic information

• Product Name: N-(4-Chlorophenyl)benzenesulfonamide
• Synonyms: Benzenesulfonanilide,4'-chloro- (7CI,8CI); 4'-Chlorobenzenesulfonanilide;N-(4-Chlorophenyl)benzenesulfonamide; N-(p-Chlorophenyl)benzenesulfonamide; NSC62066
• CAS NO: 4750-28-1
• Molecular Formula: C₁₂H₁₀ClNO₂S
• Molecular Weight: 267.74
• Mol File: 4750-28-1.mol
• Article Data: 31

Chemical Properties

• Boiling Point: 407.7°Cat760mmHg
• Flash Point: 200.4°C
• Appearance: Pale purple/Solid
• Density: 1.405g/cm³
• Vapor Pressure: 7.39E-07mmHg at 25°C
• Refractive Index: 1.641
• CAS DataBase Reference: N-(4-Chlorophenyl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Chlorophenyl)benzenesulfonamide(4750-28-1)
• EPA Substance Registry System: N-(4-Chlorophenyl)benzenesulfonamide(4750-28-1)

Safety Data

• Hazardous Substances Data: 4750-28-1(Hazardous Substances Data)

Usage

General Description

N-(4-Chlorophenyl)benzenesulfonamide, also known as 4-Chloro-N-phenylbenzenesulfonamide, is a chemical compound with the molecular formula C12H10ClNO2S. It is a sulfonamide derivative that is often used as a pharmaceutical intermediate in the synthesis of various drugs. N-(4-Chlorophenyl)benzenesulfonamide has potential applications in the field of medicinal chemistry and drug discovery, particularly in the development of antimicrobial and antitumor agents. N-(4-Chlorophenyl)benzenesulfonamide is a white to off-white powder that is sparingly soluble in water but soluble in organic solvents, making it suitable for use in various chemical reactions and pharmaceutical formulations.

InChI:InChI=1/C12H10ClNO2S/c13-10-6-8-11(9-7-10)14-17(15,16)12-4-2-1-3-5-12/h1-9,14H

Upstream product

• 1678-25-7 N-phenylbenzenesulfonamide 
• 10026-13-8 phosphorus pentachloride 
• 134305-16-1 N-chloro-N-phenylbenzenesulphonamide 
• 873-55-2 sodium benzenesulfonate 
• 106-47-8 4-chloro-aniline 
• 100-00-5 4-chlorobenzonitrile 
• 98-80-6 phenylboronic acid 
• 603-33-8 triphenylbismuthane 
• 98-10-2 benzenesulfonamide 
• 1073-70-7 4-chlorophenylhydrazine hydrochloride 
• 14752-66-0 sodium p-chlorobenzenesulphinate 
• 106-39-8 bromochlorobenzene 
• 1679-18-1 4-Chlorophenylboronic acid 
• 108-98-5 thiophenol 

Downstream Products

• 862876-04-8 N-(4-chlorophenyl)-2-methyl-2-phenylpropanamide 
• 1097201-85-8 N-(4-chlorophenyl)-3,5-dinitro-N-(phenylsulfonyl)benzamide 
• 1831-60-3 2-phenylsulfonylamino-5-chloroaniline 
• 117309-41-8 [Benzenesulfonyl-(4-chloro-phenyl)-amino]-acetic acid 
• 418806-66-3 [benzenesulfonyl-(4-chloro-phenyl)-amino]-acetic acid methyl ester 
• 312-63-0 N-(4-fluorophenyl)benzenesulfonamide 
• 1678-25-7 N-phenylbenzenesulfonamide 
• 735-58-0 2-phenylsulfonylamino-5-chloro-1-nitrobenzene 

Relevant articles and documents

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Ultrasound-assisted one-pot three-component synthesis of new isoxazolines bearing sulfonamides and their evaluation against hematological malignancies

In the present study, following a one-pot two-step protocol, we have synthesized novel sulfonamides-isoxazolines hybrids (3a-r) via a highly regioselective 1,3-dipolar cycloaddition. The present methodology capitalized on trichloroisocyanuric acid (TCCA) as a safe and ecological oxidant and chlorinating agent for the in-situ conversion of aldehydes to nitrile oxides in the presence of hydroxylamine hydrochloride, under ultrasound activation. These nitrile oxides could be engaged in 1,3-dipolar cycloaddition reactions with various alkene to afford the targeted sulfonamides-isoxazolines hybrids (3a-r). The latter were assessed for their antineoplastic activity against model leukemia cell lines (Chronic Myeloid Leukemia, K562 and Promyelocytic Leukemia, HL-60).

Sulfonamide compound and metal-free catalytic construction method and application thereof

The invention discloses a sulfonamide compound as shown in a formula (I) which is described in the specification and a synthesis method thereof. A series of sulfonamide compounds are obtained throughreaction of nitroaromatic hydrocarbon, an inorganic sulfur reagent and boric acid as reaction raw materials in a solvent under the action of alkali and an additive. Metal catalysis and an additional reducing agent are not needed, an inorganic sulfur reagent is used as a sulfur source and a reducing agent, and a series of sulfonamide compounds are constructed in one step by a three-component one-pot method. The invention also discloses an application of the sulfonamide compound in synthesis of sulfonamide drugs. The raw materials of the synthesis method are wide in source, cheap and easy to obtain; the reaction operation is simple; the substrate universality is high; and the synthesis method is economic and practical. The sulfonamide compound has high practical value and a wide applicationprospect.