4786-20-3Relevant articles and documents
C-CN BOND CLEAVAGE UNDER MILD CONDITIONS PROMOTED BY ELECTRON-RICH COBALT COMPLEXES
Ozawa, Fumiyuki,Iri, Kiyoshi,Yamamoto, Akio
, p. 1707 - 1710 (1982)
Electron-rich cobaltate dinitrogen complex, Li(Et2O)3 1, reacts with alkyl and aryl nitrile compounds causing the cleavage of C-CN bond under mild conditions to release hydrocarbons.Catalytic activity of the cobalt complex to isomerize allyl cyanide to crotononitrile is also noted.
Base controlled diverse reactivity of allyl cyanide for synthesis of multi-substituted benzenes
Yadav, Pratik,Shaw, Ranjay,Elagamy, Amr,Kumar, Abhinav,Pratap, Ramendra
, p. 5465 - 5473 (2018)
A base controlled regioselective 1,6-cyanoallylation of suitably functionalized 2H-pyran-2-ones has been demonstrated for the synthesis of various multi-substituted benzenes through a tandem process. We observed that lithium hydroxide provides a major product from α-attack and a minor product from γ-attack of allyl cyanide, while the use of sodium hydride as a base exclusively provides the product by γ-attack of allyl cyanide. We have also performed NMR experiments to understand the mechanistic pathway. The structure of the compound was confirmed by single crystal X-ray analysis.
Relative Donor-Atom Effects on Rates of Isomerization of 3-Butenenitrile Catalyzed by Anions of the Same Basicity
Bordwell, Frederick G.,Hughes, David L.
, p. 619 - 621 (1983)
For base-catalyzed isomerization of 3-butenenitrile in Me2SO solution the order of rate constants for anions of the same basicity is ArS->ArO->RSO2NAr->9-G-Fl- (9-substituted fluorenyl carbanions).The relative rate constants vary somewhat with basicity since the Broensted β values are 0.77, 1.0, 0.82, and ca. 0.8, respectively.
Unusual reactivity of N-tert-butylimines under FVT conditions
Le?niak, Stanis?aw,Pasternak, Beata,Justyna, Katarzyna,Vu, Thien Y.,Huynh, Thi Kieu Xuan,Khayar, Sa?d,Dargelos, Alain,Chrostowska, Anna
, p. 722 - 729 (2013/07/27)
Thermal reactions of N-tert-butyl-(E)-crotonaldimine (1a) and 1,4-di-(tert-butyl)-1,4-diazabuta-1,3-dien (glyoxal-bis-N-tert-butylimine) (1b) under FVT conditions have been studied. It has been found that at 800 °C compound 1a yielded pyrrole and crotonon
CONTROLLED DRUG RELEASE FROM SOLID SUPPORTS
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Page/Page column 31-32, (2011/11/30)
The invention relates to solid supports useful in medical applications that provide controlled release of drugs, such as peptides, nucleic acids and small molecules. The drugs are covalently coupled to the solid support through a linkage that releases the drug or a prodrug through controlled beta elimination.
