4826-71-5Relevant articles and documents
Hydrogen bonding Part 38. IR and thermodynamic study of phosphorylcholine chloride calcium salt tetrahydrate and monohydrate
Harmon, Kenneth M.,Akin, Anne C.
, p. 173 - 179 (1991)
Vapor pressure vs.H2O content studies demonstrate that phosphorylcholine chloride calcium salt forms two hydrates, a monohydrate and a tetrahydrate, in the range 0-4 mol H2O mol-1 of salt; there is no dihydrate or trihydrate.Equilibrium vapor pressure measurements show that ΔH0 of dissociation per mol H2O lost is greater for the tetrahydrate (16.08 kcal mol-1) than for the monohydrate (12.49 kcal mol-1); the lower stability of the tetrahydrate arises from entropy effects.The IR spetrum of the tetrahydrate is that of a framework clathrate hydrate and suggests that the -PO3 group may act as a very weak hydrogen-bond acceptor.In the monohydrate the -PO3 group is not involved in hydrogen bonding.Neither hydrate contains P-OH bonds.
Glycerin phosphatidyl choline preparation method
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Paragraph 0056-0061, (2017/12/28)
The invention discloses a preparation method for glycerophosphatidylcholine. The preparation method comprises the steps: mixing a compound shown in the formula (I) with anhydrous sodium carbonate to prepare a mixture M1; putting the mixture M1 and (R)-(-)-3-chloro-1,2-propylene glycol in anhydrous ethanol for reflux to obtain a mixture M2; after diluting the mixture M2 by 5-10 times, flowing the mixture M2 through first ion exchange resin to obtain a mixture M3; after diluting the mixture M3 by 2-4 times, flowing the mixture M3 through second ion exchange resin to obtain a mixture M4; washing the mixture M4 by 70-90wt% ethanol to obtain a mixture M5; washing the mixture M5 by distilled water to obtain a mixture M6; after flowing the mixture M6 through third ion exchange resin, filtering the mixture M6 to obtain a filtrate so as to obtain the glycerophosphatidylcholine. The formula (I) is as shown in the description, wherein R is Ca2 or Mg2. The effects of simple preparation method, high synthetic ratio and great reduction of production cost are achieved.
