Welcome to LookChem.com Sign In|Join Free

Cas Database

4926-28-7

4926-28-7

Identification

  • Product Name:Pyridine,2-bromo-4-methyl-

  • CAS Number: 4926-28-7

  • EINECS:-0

  • Molecular Weight:172.024

  • Molecular Formula: C6H6BrN

  • HS Code:29339900

  • Mol File:4926-28-7.mol

Synonyms:4-Picoline,2-bromo- (6CI,7CI,8CI);2-Bromo-4-picoline;4-Methyl-2-bromopyridine;

Post Buying Request Now
Entrust LookChem procurement to find high-quality suppliers faster

Safety information and MSDS view more

  • Pictogram(s):IrritantXi, HarmfulXn

  • Hazard Codes:Xi,Xn

  • Signal Word:Warning

  • Hazard Statement:H315 Causes skin irritationH319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:2-Bromo-4-picoline
  • Packaging:5g
  • Price:$ 140
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TCI Chemical
  • Product Description:2-Bromo-4-methylpyridine >98.0%(GC)
  • Packaging:25g
  • Price:$ 163
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TCI Chemical
  • Product Description:2-Bromo-4-methylpyridine >98.0%(GC)
  • Packaging:5g
  • Price:$ 74
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:2-Bromo-4-methylpyridine 98%
  • Packaging:1 g
  • Price:$ 20
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:2-Bromo-4-methylpyridine 98%
  • Packaging:5 g
  • Price:$ 48
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:2-Bromo-4-methylpyridine 98%
  • Packaging:25 g
  • Price:$ 116
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:2-Bromo-4-methylpyridine 97%
  • Packaging:10g
  • Price:$ 152
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:2-Bromo-4-methylpyridine 97%
  • Packaging:1g
  • Price:$ 34.2
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Oakwood
  • Product Description:2-Bromo-4-methylpyridine 97%
  • Packaging:5g
  • Price:$ 12
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Labseeker
  • Product Description:2-BROMO-4-METHYLPYRIDINE 95
  • Packaging:250g
  • Price:$ 483
  • Delivery:In stock
  • Buy Now

Relevant articles and documentsAll total 23 Articles be found

2-Carbaldoximes of pyridine-4- and 5-carboxylic acids

Reyes-Rivera,Hutchins,Dalton

, p. 665 - 669 (1995)

A series of pyridine-2-carbaldoximes, all of which are substituted at the 4- or 5-position with derivatives of the corresponding carboxylic acids, have been prepared via the corresponding pyridine-2-carbaldehydes.

Transition-metal-free decarboxylative halogenation of 2-picolinic acids with dihalomethane under oxygen conditions

Zhang, Xitao,Feng, Xiujuan,Zhang, Haixia,Yamamoto, Yoshinori,Bao, Ming

supporting information, p. 5565 - 5570 (2019/10/22)

A convenient and efficient method for the synthesis of 2-halogen-substituted pyridines is described. The decarboxylative halogenation of 2-picolinic acids with dihalomethane proceeded smoothly via N-chlorocarbene intermediates to afford 2-halogen-substituted pyridines in satisfactory to excellent yields under transition-metal-free conditions. This new type of decarboxylative halogenation is operationally simple and exhibits high functional-group tolerance.

Benzothiazole Formulations and Use Thereof

-

Page/Page column 9; 24, (2010/11/30)

The present invention is related to macrogol glyceride pharmaceutical formulations containing benzothiazole derivatives. In particular, the invention is related to benzothiazole stearoyl macrogol pharmaceutical formulations, method of preparation and use thereof.

Inhibitors of P2X3

-

Page/Page column 23, (2008/06/13)

Compounds of formula 1 are modulators of P2X3 useful for the treatment of pain and genito-urinary, gastrointestinal, and respiratory disorders: wherein R1 is —C(═S)CH3, pyridyl, pyrimidinyl, pyrazinyl, thiazolyl, furyl, furylcarbonyl, acetyl, or carbamoyl; R2a and R2b are independently H, methyl, or ethyl; R3 is H or methyl; Y is a bond, —(CR4R5)n— or —CR4═CR5—; wherein R4 and R5 are each independently H or methyl and n is 1 or 2; X is N or CH; A is phenyl, 5-membered heterocyclyl, or 6-membered heterocyclyl; R6, R7 and R8 are each independently H, halo, lower alkyl, cycloalkyl, alkylthio, alkylthio-lower alkyl, alkylsulfonyl-lower alkyl, di(lower alkyl)amino-lower alkyl, morpholinyl-lower alkyl, 4-methyl-piperazinyl-methyl, trifluoromethyl, pyridyl, tetrazolyl, thiophenyl, phenyl, biphenyl, or benzyl (where thiophenyl, phenyl and benzyl are substituted with 0-3 lower alkyl, halo, sulfonamido, trifluoromethyl, lower alkoxy or lower alkylthio) or R6 and R7 together form a 5-membered or 6-membered carbocyclic or heterocyclic ring substituted with 0-3 substituents selected from the group consisting of lower alkyl, lower alkoxy, oxo, halo, thiophenyl-lower alkyl, phenyl, benzyl (where phenyl and benzyl are substituted with 0-3 lower alkyl, halo, sulfonamido, trifluoro-methyl, lower alkoxy, lower alkylthio, amino-lower alkyl, lower alkylamino-lower alkyl, or di(lower alkyl)amino-lower alkyl); and pharmaceutically acceptable salts thereof; wherein when R1 is pyrimidin-2-yl, X is N, Y is a bond and A is oxazol-5-yl the carbon atom at position 4 in said oxazol-5-yl is not substituted by propyl when the carbon atom at position 2 in said oxazol-5-yl is substituted by substituted phenyl and the carbon atom at position 4 in said oxazol-5-yl is not substituted by phenyl when the carbon atom at position 2 is substituted by unsubstituted or substituted phenyl.

Cyclometalated transition metal complex and organic electroluminescent device using the same

-

, (2008/06/13)

A cyclometalated transition metal complex emitting phosphorescence of high efficiency and an organic electroluminescent display device employing the same are provided. The cyclometalated transition metal complex has a transition metal atom and a phosphorus ligand having at least one alkylene oxide and a phosphorus atom. The phosphorus atom is bound to the transition metal atom. The cyclometalated transition metal complex can be employed when forming an organic film of an organic electroluminescent display device, can emit light at a wavelength range of 400 nm to 650 nm, and can emit white light as well when used with a green light emitting material and a red light emitting material.

The expedient access to bromo-pyridine carbaldehyde scaffolds using gem-dibromomethyl intermediates

Mandal, Ashis Baran,Augustine, John Kallikat,Quattropani, Anna,Bombrun, Agnes

, p. 6033 - 6036 (2007/10/03)

A simple, efficient, and general two-step synthesis to bromo-pyridine carbaldehyde scaffolds is described. This direct route involves sequential reactions employing the dibromination of bromo-picolines followed by hydrolysis using an aqueous solution of calcium carbonate. Bromo-pyridine carbaldehyde scaffolds 1-7 were obtained in good overall yield. Bromo-dibromomethyl-pyridine intermediates have been isolated and characterized.

Process route upstream and downstream products

Process route

2-Amino-4-methylpyridine
695-34-1

2-Amino-4-methylpyridine

2-Bromo-4-picoline
4926-28-7

2-Bromo-4-picoline

Conditions
Conditions Yield
With hydrogen bromide; bromine; sodium nitrite; In water; at 0 ℃; for 3h;
94%
With sodium hydroxide; hydrogen bromide; bromine; sodium nitrite; In water;
90%
With hydrogen bromide; bromine; sodium nitrite; at 5 ℃;
87%
2-Amino-4-methylpyridine; With hydrogen bromide; bromine; In water; at -20 - -15 ℃; for 3h;
With sodium nitrite; In water; at 20 ℃; for 3h;
With sodium hydroxide; In water; at 0 ℃; pH=12;
86%
With hydrogen bromide; bromine; sodium nitrite; at 0 ℃;
85%
2-Amino-4-methylpyridine; With bromine; at -20 ℃; for 1.5h;
With sodium nitrite; at -20 - 15 ℃;
With sodium hydroxide; at -10 - 20 ℃; Further stages.;
85%
With hydrogen bromide; bromine; sodium nitrite;
Multistep reaction; diazonium reaction;
With hydrogen bromide; bromine; sodium nitrite; Yield given. Multistep reaction; 1.) 1 h, 0 deg C; 2.) water, below 5 deg C;
With hydrogen bromide; bromine; sodium nitrite; at 5 - 20 ℃; for 1h;
With hydrogenchloride; bromine; sodium nitrite; Yield given. Multistep reaction;
2-Amino-4-methylpyridine; With hydrogen bromide; bromine; In water; at -20 ℃; for 0.833333h;
With sodium nitrite; In water; at -20 ℃; for 2.5h;
With sodium hydroxide; hydrogen bromide; bromine; sodium nitrite; In water;
With sodium hydroxide; hydrogen bromide; bromine; sodium nitrite; In water;
2-Amino-4-methylpyridine; With hydrogen bromide; bromine; In water; at -20 ℃; for 1.16667h;
With sodium nitrite; In water; at -20 - 15 ℃; for 2h;
With sodium hydroxide; In water; at -10 - 20 ℃;
With hydrogen bromide; bromine; sodium nitrite;
picoline
108-89-4

picoline

2-Bromo-4-picoline
4926-28-7

2-Bromo-4-picoline

Conditions
Conditions Yield
picoline; With n-butyllithium; 2-(N,N-dimethylamino)ethanol; In hexane; at 0 ℃; for 1h;
With carbon tetrabromide; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Further stages.;
70%
2-hydroksy-4-methyl-pyridine
13466-41-6,91914-05-5

2-hydroksy-4-methyl-pyridine

ethyl acetate-water

ethyl acetate-water

Bromoform
75-25-2

Bromoform

2-Bromo-4-picoline
4926-28-7

2-Bromo-4-picoline

Conditions
Conditions Yield
With phosphorus tribromide; In water;
picoline
108-89-4

picoline

acetyl hypofluorite
78948-09-1

acetyl hypofluorite

2-Bromo-4-picoline
4926-28-7

2-Bromo-4-picoline

4-methylpyridin-2-yl acetate
108168-80-5

4-methylpyridin-2-yl acetate

Conditions
Conditions Yield
With 1,1-dibromomethane; Ambient temperature;
55%
2-Amino-4-methylpyridine
695-34-1

2-Amino-4-methylpyridine

2-Bromo-4-picoline
4926-28-7

2-Bromo-4-picoline

2-bromo-4-bromomethyl pyridine
83004-14-2

2-bromo-4-bromomethyl pyridine

Conditions
Conditions Yield
4-methylpicolinic acid
4021-08-3

4-methylpicolinic acid

2-Bromo-4-picoline
4926-28-7

2-Bromo-4-picoline

Conditions
Conditions Yield
With tert-butylhypochlorite; dichloromethane; oxygen; sodium hydrogencarbonate; at 70 ℃; for 20h; Green chemistry;
55 %Spectr.
2-Bromo-4-picoline
4926-28-7

2-Bromo-4-picoline

Conditions
Conditions Yield
2-Bromo-4-picoline
4926-28-7

2-Bromo-4-picoline

F2pmp dimer

F2pmp dimer

Conditions
Conditions Yield
2-Amino-4-methylpyridine
695-34-1

2-Amino-4-methylpyridine

2-Bromo-4-picoline
4926-28-7

2-Bromo-4-picoline

Conditions
Conditions Yield
With hydrogen bromide; bromine; sodium nitrite; In water; at 0 ℃; for 3h;
94%
With sodium hydroxide; hydrogen bromide; bromine; sodium nitrite; In water;
90%
With hydrogen bromide; bromine; sodium nitrite; at 5 ℃;
87%
2-Amino-4-methylpyridine; With hydrogen bromide; bromine; In water; at -20 - -15 ℃; for 3h;
With sodium nitrite; In water; at 20 ℃; for 3h;
With sodium hydroxide; In water; at 0 ℃; pH=12;
86%
With hydrogen bromide; bromine; sodium nitrite; at 0 ℃;
85%
2-Amino-4-methylpyridine; With bromine; at -20 ℃; for 1.5h;
With sodium nitrite; at -20 - 15 ℃;
With sodium hydroxide; at -10 - 20 ℃; Further stages.;
85%
With hydrogen bromide; bromine; sodium nitrite;
Multistep reaction; diazonium reaction;
With hydrogen bromide; bromine; sodium nitrite; Yield given. Multistep reaction; 1.) 1 h, 0 deg C; 2.) water, below 5 deg C;
With hydrogen bromide; bromine; sodium nitrite; at 5 - 20 ℃; for 1h;
With hydrogenchloride; bromine; sodium nitrite; Yield given. Multistep reaction;
2-Amino-4-methylpyridine; With hydrogen bromide; bromine; In water; at -20 ℃; for 0.833333h;
With sodium nitrite; In water; at -20 ℃; for 2.5h;
With sodium hydroxide; hydrogen bromide; bromine; sodium nitrite; In water;
With sodium hydroxide; hydrogen bromide; bromine; sodium nitrite; In water;
2-Amino-4-methylpyridine; With hydrogen bromide; bromine; In water; at -20 ℃; for 1.16667h;
With sodium nitrite; In water; at -20 - 15 ℃; for 2h;
With sodium hydroxide; In water; at -10 - 20 ℃;
With hydrogen bromide; bromine; sodium nitrite;
picoline
108-89-4

picoline

2-Bromo-4-picoline
4926-28-7

2-Bromo-4-picoline

Conditions
Conditions Yield
picoline; With n-butyllithium; 2-(N,N-dimethylamino)ethanol; In hexane; at 0 ℃; for 1h;
With carbon tetrabromide; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Further stages.;
70%

Global suppliers and manufacturers

Global( 179) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • Chemwill Asia Co., Ltd.
  • Business Type:Manufacturers
  • Contact Tel:021-51086038
  • Emails:sales@chemwill.com
  • Main Products:30
  • Country:China (Mainland)
  • Amadis Chemical Co., Ltd.
  • Business Type:Lab/Research institutions
  • Contact Tel:86-571-89925085
  • Emails:sales@amadischem.com
  • Main Products:29
  • Country:China (Mainland)
  • Shaanxi BLOOM TECH Co.,Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-29-86470566
  • Emails:sales@bloomtechz.com
  • Main Products:80
  • Country:China (Mainland)
  • Shanghai Upbio Tech Co.,Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-21-52196435
  • Emails:upbiocn@hotmail.com
  • Main Products:88
  • Country:China (Mainland)
  • LIDE PHARMACEUTICALS LIMITED
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-25-58409506
  • Emails:lide@lidepharma.com
  • Main Products:56
  • Country:China (Mainland)
close
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 4926-28-7
Post Buying Request Now
close
Remarks: The blank with*must be completed