5418-11-1

Basic information

• Product Name: PHENYL TRANS-STYRYL SULFONE 99
• Synonyms: PHENYL TRANS-STYRYL SULFONE 99;[2-(Phenylsulfonyl)vinyl]benzene;2-Phenylethenyl phenyl sulfone;Phenyl styryl sulfone;Styryl phenyl sulfone;β-(Phenylsulfonyl)styrene
• CAS NO: 5418-11-1
• Molecular Formula: C₁₄H₁₂O₂S
• Molecular Weight: 244.31
• Product Categories: Organic Building Blocks;Sulfones;Sulfur Compounds
• Mol File: 5418-11-1.mol

Chemical Properties

• Melting Point: 74-75 °C(lit.)
• Boiling Point: 438.2°Cat760mmHg
• Flash Point: 275.1°C
• Appearance: /
• Density: 1.221g/cm³
• CAS DataBase Reference: PHENYL TRANS-STYRYL SULFONE 99(CAS DataBase Reference)
• NIST Chemistry Reference: PHENYL TRANS-STYRYL SULFONE 99(5418-11-1)
• EPA Substance Registry System: PHENYL TRANS-STYRYL SULFONE 99(5418-11-1)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 5418-11-1(Hazardous Substances Data)

Usage

Uses

Used in Plastics Industry:
PHENYL TRANS-STYRYL SULFONE 99 is used as a key component in the production of various types of plastics. Its unique chemical structure and reactivity contribute to the development of plastics with enhanced properties, such as improved thermal stability and mechanical strength.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, PHENYL TRANS-STYRYL SULFONE 99 is utilized as an intermediate in the synthesis of potential drug candidates. Its distinctive chemical properties make it a promising compound for the development of new medications with novel therapeutic effects.
Used in Organic Synthesis:
PHENYL TRANS-STYRYL SULFONE 99 is employed as a versatile building block in organic synthesis. It is used to create a variety of organic compounds, which can be further utilized in different applications across various industries, including the production of specialty chemicals and materials with specific properties.

Upstream product

• 2643-39-2 1-Benzenesulphonyl-2-bromo-2-phenylethane 
• 17872-92-3 (phenylsulfonylmethyl)trimethylsilane 
• 100-52-7 benzaldehyde 
• 873-55-2 sodium benzenesulfonate 
• 536-74-3 phenylacetylene 
• 40824-67-7 Acetic acid 2-benzenesulfonyl-1-phenyl-ethyl ester 
• 40824-68-8 (2-Benzenesulfonyl-1-phenyl-ethyl)-trimethyl-ammonium 
• 16619-61-7 1-phenyl-2-phenylthioethene 
• 100-42-5 styrene 
• 62-53-3 aniline 
• 96-09-3 styrene oxide 
• 100-51-6 benzyl alcohol 
• 98-09-9 benzenesulfonyl chloride 
• 369-57-3 benzenediazonium tetrafluoroborate 

Downstream Products

• 69333-48-8 1-phenyl sulphonyl-2-methoxy-2-phenyl ethane 
• 18436-04-9 phenyl(β-phenyl sulphenyl-β-phenyl ethyl)sulphone 
• 91152-57-7 C₁₇H₁₉NO₄S 
• 26995-39-1 (1RS,2SR)-1,2-epoxy-2-phenylethyl phenyl sulfone 
• 97764-03-9 C₁₇H₁₉NO₄S 
• 70941-85-4 1-<(E)-2-Phenyl-1-phenylsulfonyl-1-ethenyl>-cyclohexanol 
• 65885-20-3 (2-benzenesulfonyl-1-phenyl-ethyl)-dimethyl-amine 
• 30246-74-3 {[(1E)-1-phenylprop-1-en-2-yl]sulfonyl}benzene 
• 170642-39-4 (2S,5R)-2-((R)-2-Benzenesulfonyl-1-phenyl-ethyl)-3,6-diethoxy-5-isopropyl-2,5-dihydro-pyrazine 
• 170899-20-4 (2S,5R)-2-((S)-2-Benzenesulfonyl-1-phenyl-ethyl)-3,6-diethoxy-5-isopropyl-2,5-dihydro-pyrazine 
• 100-42-5 styrene 
• 108-98-5 thiophenol 
• 85978-16-1 (4R,5S)-4-Benzenesulfonyl-3,5-diphenyl-4,5-dihydro-isoxazole 
• 16212-05-8 (allylsulfonyl)benzene 

Relevant articles and documents

Sodium iodide-mediated synthesis of vinyl sulfides and vinyl sulfones with solvent-controlled chemical selectivity

Vinyl sulfides and vinyl sulfones are ubiquitous structures in organic chemistry because of their presence in natural and biologically active compounds and are very frequently encountered structural motifs in organic synthesis. Herein we report an efficie

Sulfonylation of Aryl Halides by Visible Light/Copper Catalysis

An efficient visible-light-assisted, copper-catalyzed sulfonylation of aryl halides with sulfinates is reported. In our protocol, a single ligand CuI photocatalyst formed in situ was used in the photocatalytic transformation. Diverse organosulfones were obtained in moderate to good yields. This strategy demonstrates a promising approach toward the synthesis of diverse and useful organosulfones.

Visible-light-mediated alkylation of 4-alkyl-1,4-dihydropyridines with alkenyl sulfones

Herein we report a mild, general protocol for visible-light-mediated alkylation of 4-alkyl-1,4-dihydropyridines with alkenyl sulfones. The protocol permits efficient functionalization of sulfones with a broad range of cyclic and acyclic secondary and tert

Silyloxymethanesulfinate as a sulfoxylate equivalent for the modular synthesis of sulfones and sulfonyl derivatives

An efficient protocol for the modular synthesis of sulfones and sulfonyl derivatives has been developed utilizing sodium tert-butyldimethylsilyloxymethanesulfinate (TBSOMS-Na) as a sulfoxylate (SO22-) equivalent. TBSOMS-Na, easily prepared from the commercial reagents Rongalite and TBSCl, serves as a potent nucleophile in S-alkylation and Cu-catalyzed S-arylation reactions with alkyl and aryl electrophiles. The sulfone products thus obtained can undergo the second bond formation at the sulfur center with various electrophiles without a separate unmasking step to afford sulfones and sulfonyl derivatives such as sulfonamides and sulfonyl fluorides.

Catalyst-Free Deaminative Functionalizations of Primary Amines by Photoinduced Single-Electron Transfer

The use of pyridinium-activated primary amines as photoactive functional groups for deaminative generation of alkyl radicals under catalyst-free conditions is described. By taking advantage of the visible light absorptivity of electron donor–acceptor complexes between Katritzky pyridinium salts and either Hantzsch ester or Et3N, photoinduced single-electron transfer could be initiated in the absence of a photocatalyst. This general reactivity platform has been applied to deaminative alkylation (Giese), allylation, vinylation, alkynylation, thioetherification, and hydrodeamination reactions. The mild conditions are amenable to a diverse range of primary and secondary alkyl pyridiniums and demonstrate broad functional group tolerance.

Electrooxidative Metal-Free Dehydrogenative α-Sulfonylation of 1H-Indole with Sodium Sulfinates

A method for the electrochemical α-sulfonylation of 1H-indole with arenesulfinates was developed. A variety of indoles underwent this sulfonylation smoothly at room temperature under metal-free and chemical-oxidant-free conditions to afford indolyl aryl sulfones in good to high yields. This reaction was found to tolerate a variety of functional groups, including halides and cyclopropyl, ether, ester, and aldehyde groups. It was applied to the synthesis of biologically active 5-HT6 modulators.

Palladium-Catalyzed Fluorosulfonylvinylation of Organic Iodides

A palladium-catalyzed fluorosulfonylvinylation reaction of organic iodides is described. Catalytic Pd(OAc)2 with a stoichiometric amount of silver(I) trifluoroacetate enables the coupling process between either an (hetero)aryl or alkenyl iodide with ethenesulfonyl fluoride (ESF). The method is demonstrated in the successful syntheses of eighty-eight otherwise difficult to access compounds, in up to 99 % yields, including the unprecedented 2-heteroarylethenesulfonyl fluorides and 1,3-dienylsulfonyl fluorides.

An efficient one-pot, three-component synthesis of vinyl sulfones via iodide-catalyzed radical alkenylation

An efficient one-pot, three-component synthesis of vinyl sulfones via iodide-catalyzed radical alkenylation using aryl diazonium salts, terminal alkenes and DABSO is reported. This protocol offers good yields and tolerates a broad range of functional groups. Based on the extensive control experiments, we propose a plausible radical mechanism.