5700-60-7Relevant articles and documents
Synthesis, characterization and biological studies of a sterically hindered symmetrical nitrogen donor ligand and its metal complexes
Arish, D.,Bhuvanesh, N.,Kumaresan, S.,Shiju, C.
, (2021/06/15)
A new sterically hindered Schiff base ligand (SN-NNDMB) was synthesized from meso-1,2-diphenyl ethylenediamine (meso-stien) and 4-N,N′-dimethylaminobenzaldehyde. Its structure was determined by single-crystal X-ray diffraction data. The crystal structure of the organic ligand was found to be triclinic, space group P-1 with a = 6.1407(8) ?, b = 8.8372(12) ?, c = 12.0006(15) ?, α = 103.882(7)°, β = 95.325(8)°, γ = 91.082(7)°, F(0 0 0) = 254, Dc = 1.253 Mg/m3, μ = 0.571 mm?1, R = 0.0399, and wR = 0.1019. Co, Ni, Cu and Zn complexes of SN-NNDMB were also prepared and characterized by elemental analysis, IR-, mass-, NMR- and electronic- spectra, magnetic moment, molar conductance, powder XRD, and TGA. The obtained results show that the Schiff base ligand acts as a bidentate, coordinated through the azomethine nitrogen atoms. According to the biotest such as Antimicrobial, DNA binding, DNA cleaving, Anti-tubercular, Anticancer, and SOD-like activity, the compounds showed better activity after chelation. The Cu(II)-SN-NNDMB complex showed the highest bioactive potential amonst the analyzed compounds.
Chemoselective Photoredox Synthesis of Unprotected Primary Amines Using Ammonia
Rong, Jiawei,Seeberger, Peter H.,Gilmore, Kerry
supporting information, p. 4081 - 4085 (2018/07/15)
Unprotected α-amino carbon radicals are produced as novel intermediates via a transformation that merges acid-promoted N-H imine generation and chemoselective photocatalytic single-electron reduction. Coupling ammonia and aldehydes/ketones allows the generation of primary amines under mild conditions without the need for protecting groups. The key intermediate can be efficiently transformed into primary (di)amines by a formal dimerization, reductive amination via hydrogen atom transfer, and arylation through radical-radical coupling.
Enantio- and Diastereoselective Nitro-Mannich Reaction of α-Aryl Nitromethanes with Amidosulfones Catalyzed by Phase-Transfer Catalysts
Lu, Ning,Li, Ruxu,Wei, Zhonglin,Cao, Jungang,Liang, Dapeng,Lin, Yingjie,Duan, Haifeng
, p. 4668 - 4676 (2017/05/12)
A high-yield, highly diastereo- and enantioselective nitro-Mannich reaction of α-aryl nitromethanes with amidosulfones catalyzed by a novel chiral phase-transfer catalyst, bearing multiple H-bonding donors, derived from quinine was developed. A variety of α-aryl nitromethanes and amidosulfones were investigated; and the corresponding products were obtained in excellent yields with excellent diastereo- and enantioselectivities (up to 99% yield, > 99:1 dr and >99% ee). As a demonstration of synthetic utility, the resulting β-nitroamines could be converted to corresponding meso-symmetric and optically pure unsymmetric anti-1,2-diarylethylenediamines.