582-17-2Relevant articles and documents
Method for synthesizing 2,7-dioxynaphthalene
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Paragraph 0009; 0021-0042, (2018/08/28)
The invention relates to a method for synthesizing 2,7-dioxynaphthalene. The method comprises the following steps: adding 2,7-naphthyldisulfnate, sodium hydroxide, sodium oxide and a solvent into a high-pressure kettle; then heating to the temperature of 260-350 DEG C and carrying out stirring reaction at the temperature; cooling the obtained solution to a room temperature while stirring; after filtering, neutralizing a filter cake by using a sulfuric acid solution to PH 0-4; and filtering and drying the obtained suspension to obtain the final product. Compared with an existing method, the method uses a mixed alkali fusion reagent consisting of sodium hydroxide and sodium oxide to replace traditional independently used sodium hydroxide, the use amount of the sodium hydroxide is greatly reduced, enrichment of water in a reaction system is avoided, therefore, the generation amount of an alkali fusion by-product is reduced remarkably, and the yield of the 2,7-dioxynaphthalene is high.
Reductive cleavage of aryl O-carbamates to phenols by the Schwartz reagent. Expedient link to the directed ortho metalation strategy?
Morin, Justin,Zhao, Yigang,Snieckus, Victor
supporting information, p. 4102 - 4105 (2013/09/12)
A general, mild, and efficient method for the reductive cleavage of aryl O-carbamates to phenols, 1 → 2 using the Schwartz reagent is reported. The method is selective, tolerating a large number of functional groups; may be carried out by direct or by an economical in situ procedure; and, notably, establishes a synthetic connection to the directed ortho metalation strategy (Figure 1) allowing new entries into difficult to prepare contiguously substituted aromatics and heteroaromatics.
Highly efficient and scalable process for demethylation of 6-(2,4-dimethoxybenzoyl)chromen-2-one and other aryl methyl ethers
Srivastava, Amit,Yang, Jason,Zhao, Baoshu,Jiang, Yong,Blackmon, Wade,Kraemer, Bernd
experimental part, p. 1765 - 1771 (2010/07/07)
Demethylation of 6-(2,4-dimethoxybenzoyl)chromen-2-one and some other aryl methyl ethers was achieved with pyridinium bromide as demethylating agent and sulfolane as solvent. Compared with other demethylation methods, this combination offers advantages of clean conversion, excellent yields, easy operation and workup, and manageable reaction temperatures. This process could be particularly useful for large-scale production because it avoids use of corrosive or moisture-sensitive reagents. Copyright