615-60-1

Basic information

• Product Name: 4-Chloro-1,2-dimethylbenzene
• Synonyms: 4-Chloro-ortho-xylene;o-Xylene, 4-chloro-;4-CHLORO-1,2-XYLENE;4-CHLORO-1,2-DIMETHYLBENZENE;4-CHLORO-O-XYLENE;3,4-DIMETHYLCHLOROBENZENE;1-CHLORO-3,4-DIMETHYLBENZENE;CHLORO-1,2-DIMETHYLBENZENE
• CAS NO: 615-60-1
• Molecular Formula: C8H9Cl
• Molecular Weight: 140.61
• EINECS: 210-438-6
• Product Categories: Aromatic Hydrocarbons (substituted) & Derivatives;Halogen toluene;Chlorine Compounds
• Mol File: 615-60-1.mol

Chemical Properties

• Melting Point: -6°C
• Boiling Point: 221-223 °C(lit.)
• Flash Point: 152 °F
• Appearance: Clear colorless/Liquid
• Density: 1.047 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.685mmHg at 25°C
• Refractive Index: n20/D 1.528(lit.)
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• Water Solubility: 27mg/L at 26℃
• BRN: 2076514
• CAS DataBase Reference: 4-Chloro-1,2-dimethylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-1,2-dimethylbenzene(615-60-1)
• EPA Substance Registry System: 4-Chloro-1,2-dimethylbenzene(615-60-1)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21
• Safety Statements: 26-36-36/37-23
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 615-60-1(Hazardous Substances Data)

Usage

Uses

Used in Biochemical Applications:
4-Chloro-1,2-dimethylbenzene is used as an inhibitor for TDG (Tet methylcytosine dioxygenase) activity. This application is particularly relevant in the field of epigenetics, where it can help regulate gene expression by modulating the activity of TDG enzymes.
Used in Chemical Synthesis:
In the chemical industry, 4-Chloro-1,2-dimethylbenzene can be utilized as a starting material or intermediate in the synthesis of various organic compounds, taking advantage of its unique chemical structure and reactivity.
Used in Solvent Applications:
Due to its liquid state and chemical stability, 4-Chloro-1,2-dimethylbenzene can be employed as a solvent in various chemical processes, facilitating reactions and improving the efficiency of certain industrial applications.
Used in Pharmaceutical Research:
4-Chloro-1,2-dimethylbenzene may also find use in the pharmaceutical sector, particularly in drug discovery and development. Its unique chemical properties could make it a valuable tool in the design and synthesis of new therapeutic agents.

Flammability and Explosibility

Nonflammable

InChI:InChI=1/C8H9Cl/c1-6-3-4-8(9)5-7(6)2/h3-5H,1-2H3

Upstream product

• 95-47-6 o-xylene 
• 7397-06-0 4-t-butyl-o-xylene 
• 7553-56-2 iodine 
• 7782-50-5 chlorine 
• 64-19-7 acetic acid 
• 86119-84-8 phosphoric acid 
• 7499-12-9 3,4-dimethyl-4-trichloromethyl-2,5-cyclohexadien-1-one 
• 618-01-9 3,4-dimethylbenzenesulfonic acid 
• 52899-12-4 1,2-dimethyl-4-(1,1-dimethylpropyl)benzene 
• 95-64-7 4-amino-o-xylene 

Downstream Products

• 5006-39-3 2,3,3’,4’-tetramethyl-1,1‘-biphenyl 
• 1076690-96-4 2-chloro-4,5-dimethyl phenyl acetic acid 
• 1076690-95-3 (2-chloro-4,5-dimethyl-phenyl)-oxo-acetic acid 
• 22884-95-3 3,4-dimethylbenzonitrile 
• 198291-18-8 3,4-dimethylphenyl-4'-methoxyphenylamine 
• 127168-76-7 5-chloro-2,3-dihydro-1H-isoindole 
• 401797-00-0 2-(3,4-dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 56038-89-2 N-(1-ethylpropyl)-3,4-dimethyl-benzenamine 
• 1092448-45-7 2-(2-cyclobutyloxy-3-methyl-benzoylamino)-5-chloro-indan-2-carboxylic acid ethyl ester 
• 1092445-88-9 2-(2-cyclobutyloxy-3-methyl-benzoylamino)-5-chloro-indan-2-carboxylic acid 
• 58230-70-9 N-(4-nitro-2-chlorophenyl)-4-chlorophthalimide 
• 58230-68-5 N-(4-nitro-o-tolyl)-4-chlorophthalimide 
• 58231-21-3 N-(4-carboxy-o-tolyl)-4-chlorophthalimide 
• 58230-71-0 N-(4-amino-2-chlorophenyl)-4-chlorophthalimide 

Relevant articles and documents

Synthetic method of 1-(4-iodophenyl)-5-chlorinisobenzofuran

The invention relates to a synthetic method of a compound, in particular to a synthetic method of 1-(4-iodophenyl)-5-chlorinisobenzofuran.By means of the method, the 1-(4-iodophenyl)-5-chlorinisobenzofuran is obtained through a series of reactions of oxidation, condensation and the like.The method is mild in reaction condition and high in yield.

Aromatic substitution in ball mills: Formation of aryl chlorides and bromides using potassium peroxomonosulfate and NaX

Aryl chlorides and bromides are formed from arenes in a ball mill using KHSO5 and NaX (X = Cl, Br) as oxidant and halogen source, respectively. Investigation of the reaction parameters identified operating frequency, milling time, and the number of milling balls as the main influencing variables, as these determine the amount of energy provided to the reaction system. Assessment of liquid-assisted grinding conditions revealed, that the addition of solvents has no advantageous effect in this special case. Preferably activated arenes are halogenated, whereby bromination afforded higher product yields than chlorination. Most often reactions are regio- and chemoselective, since p-substitution was preferred and concurring side-chain oxidation of alkylated arenes by KHSO5 was not observed. The Royal Society of Chemistry.

Microwave assisted solid additive effects in simple dry chlorination reactions with n-chlorosuccinimide

Solid additives participate in the dry microwave assisted chlorination reaction of N-chlorosuccinimide with the xylenes affecting both yields and chemoselectivities. Total yields can be increased up to nine times for simple alkylaromatics and chemoselectivities can be altered according to the desired ring or α-side chlorination product by choosing the appropriate additive. We believe that in these reactions the solid additives play a very important role by increasing yields and affecting chemoselectivities, as well as behaving as microwave energy absorbers that consequently aid the transfer of heat to the active reagents.

Regiospecific chlorination of xylenes using K-10 montmorrillonite clay

Regiospecific chlorination of xylenes has been developed by employing NCS as a reagent and K-10 montmorrillonite clay as a solid support. Copyright Taylor & Francis Group, LLC.

Chlorination of aromatic substrates catalyzed by the phthalocyanine complexes

The chlorination of benzene, toluene, and o-xylene with molecular chlorine in the presence of the phthalocyanine complexes of different structures was studied. The transformations of the catalysts during the reaction were investigated.

Grindstone chemistry: (Diacetoxyiodo)benzene-mediated oxidative nuclear halogenation of arenes using NaCl, NaBr or I2

A technique of "Grindstone chemistry" is applied to the solvent-free halogenation of arenes with NaCl, NaBr or I2 using (diacetoxyiodo)benzene as the oxidant. Improved yields and higher purities of the products are observed compared with those from established methods.

PROCESS FOR HALOGENATION OF BENZENE AND BENZENE DERIVATIVES

In a process of halogenation of benzene or benzene derivatives, di-substituted halobenzene derivatives having para-aromatic compounds or tri-substituted halobenzene derivatives having 1,2,4-substituted aromatic compounds are selectively produced. In halogenation of benzene or benzene derivatives, a fluorine-containing zeolite catalyst such as L-type zeolite, or a zeolite catalyst having the crystal size of at most 100 nm is used. The reaction is preferably effected in the presence of a solvent, and the solvent is preferably a halogenated compound.

Catalyst composition and method for chlorinating aromatic compounds

Aromatic compounds such as toluene and o-xylene are chlorinated in the presence of a catalyst combination prepared by combining (A) at least one salt comprising a metal selected from the group consisting of a Group 4-12 metal, a lanthanide and an actinide; and a counterion; and (B) at least one organic sulfur compound, preferably phenothiazine-N-carbonyl chloride. The catalyst combination may include reaction products of (A) and (B). Under these conditions, production of the p-chloro isomer is optimized. In some embodiments said counterion is an organic counterion derived from at least one acidic organic compound selected from the group consisting of those with an approximate pKa value relative to water of at least about 3.

Process for the hydrodechlorination of nuclear chlorinated ortho-xylenes

A process for the hydrodechlorination of nuclear-chlorinated o-xylene and recovery of o-xylene with the formation of HCl comprises hydrogenation of the nuclear-chlorinated o-xylene at a noble metal containing catalyst at 220-360 degrees C.

Process for the nuclear chlorination of ortho-xylene

A process for the chlorination of the nucleus of ortho-xylene comprises reaction of ortho-xylene and a chlorinating agent in the presence of a Friedel-Crafts catalyst and chlorine-substituted 2,8-dimethyl-phenoxathiine as a cocatalyst.