61832-41-5Relevant articles and documents
A simple and environmentally benign synthesis of novel spiro[indoline-3,5′-pyrano[2,3-d]pyrimidine] derivatives in water
Ghadiri, Sakineh,Bayat, Mohammad,Hosseini, Fahimeh Sadat
, p. 1079 - 1084 (2019/03/14)
Abstract: A green, convenient, and efficient one-pot synthesis of a new class of spiro[indolinepyranopyrimidine] derivatives was achieved in good yields by the multi-component reaction of N-alkyl-1-(methylthio)-2-nitroethenamine derived from the addition
Rapid and catalyst free synthesis of new bis(benzo[: G] chromene) and bis(pyrano[3,2- c] chromene) derivatives and optimization of reaction conditions using response surface methodology
Hosseini, Fahimeh Sadat,Bayat, Mohammad,Afsharnezhad, Milad
, p. 39466 - 39474 (2019/12/15)
4,4′-(1,4-phenylene)bis(2-(alkylamino)-3-nitro-4H-benzo[g]chromene-5,10-dione) and 4,4′-(1,4-phenylene)bis(2-(alkylamino)-3-nitropyrano[3,2-c]chromen-5(4H)-one) derivatives are synthesized by a one-pot, multi-component reaction of N-alkyl-1-(methylthio)-2
Synthesis of Spiro[indoline-3,4′-pyrano[3,2-c]chromene]diones
Ghadiri, Sakineh,Bayat, Mohammad,Hosseini, Fahimeh Sadat
, p. 2693 - 2697 (2018/10/20)
A new series of isatin-based spiro-fused derivatives were prepared, via three-component reaction of N-alkyl-1-(methylthio)-2-nitroethenamine derived from the addition of various amines to nitroketene dithioacetal with isatin derivatives and 4-hydroxycouma
Critical Influence of 5-Hydroxymethylfurfural Aging and Decomposition on the Utility of Biomass Conversion in Organic Synthesis
Galkin, Konstantin I.,Krivodaeva, Elena A.,Romashov, Leonid V.,Zalesskiy, Sergey S.,Kachala, Vadim V.,Burykina, Julia V.,Ananikov, Valentine P.
supporting information, p. 8338 - 8342 (2016/07/19)
Spectral studies revealed the presence of a specific arrangement of 5-hydroxymethylfurfural (5-HMF) molecules in solution as a result of a hydrogen–bonding network, and this arrangement readily facilitates the aging of 5-HMF. Deterioration of the quality of this platform chemical limits its practical applications, especially in synthesis/pharma areas. The model drug Ranitidine (Zantac) was synthesized with only 15 % yield starting from 5-HMF which was isolated and stored as an oil after a biomass conversion process. In contrast, a much higher yield of 65 % was obtained by using 5-HMF isolated in crystalline state from an optimized biomass conversion process. The molecular mechanisms responsible for 5-HMF decomposition in solution were established by NMR and ESI-MS studies. A highly selective synthesis of a 5-HMF derivative from glucose was achieved using a protecting group at O(6) position.
A 1 - methylamino -1 - methylthio -2 - nitroethylene method for the preparation of
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Paragraph 0073; 0074; 0075; 0076; 0077, (2016/10/09)
The invention relates to the field of chemical synthesis, and especially relates to a preparation method for 1-methylamino-1-methylthio-2-nitroethylene. The preparation method comprises: in the presence of a solvent, taking nitromethane, carbon disulfide and potassium hydroxide to perform a condensation reaction, so as to obtain a compound of a formula II; taking the compound of the formula II and methylamine to perform amination reaction, so as to obtain a compound of a formula III and hydrosulfide ion which is reacted with an acid for generating hydrogen sulfide; taking the compound of the formula III, a methylation reagent and an alkali to perform a methylation reaction, so as to obtain 1-methylamino-1-methylthio-2-nitroethylene crude product; and refining the crude product, so as to obtain 1-methylamino-1-methylthio-2-nitroethylene. The provided preparation method for 1-methylamino-1-methylthio-2-nitroethylene eliminates generation of a main gas pollution source methyl mercaptan, guarantees product quality, substantially reduces usage amount of the raw materials, shortens the reaction time and improves the product yield.
POLYFLUORINATED COMPOUNDS ACTING AS BRUTON TYROSINE KINASE INHIBITORS
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Paragraph 0633; 0634, (2016/08/17)
Described herein is a novel series of multi-fluoro-substituted pyrazolopyrimidine compounds or salts thereof. These compounds are Bruton's tyrosine kinase (BTK) inhibitors. These compounds may possess better BTK inhibition selectivity and pharmacokinetic properties. Disclosed herein are the synthesis methods of these compounds. Disclosed herein are novel synthesis methods of the multi-fluoro-substituted benzophenone and substituted phenoxy benzene. Also disclosed are pharmaceutical compositions comprising the BTK inhibitors described herein. The present invention also relates to pharmaceutical formulations comprising the compounds described herein as active ingredients. The present invention also includes the therapeutic methods by administering the BTK inhibitors and their formulations to treat and inhibit autoimmune disease, hypersensitivity disease, inflammatory diseases and cancer.
An efficient synthesis of N-substituted 3-nitrothiophen-2-amines
Kumar, Sundaravel Vivek,Muthusubramanian, Shanmugam,Menéndez, J. Carlos,Perumal, Subbu
supporting information, p. 1707 - 1712 (2016/04/10)
A novel protocol for the synthesis of 3-nitro-N-aryl/alkylthiophen-2-amines in good yields from the reaction of α-nitroketene N,S-aryl/alkylaminoacetals and 1,4-dithiane-2,5-diol in the presence of K2CO3 in refluxing ethanol is descr
Design, synthesis, and particular biological behaviors of chain-opening nitromethylene neonicotinoids with cis configuration
Lu, Siyuan,Shao, Xusheng,Li, Zhong,Xu, Zhiping,Zhao, Shishuai,Wu, Yinli,Xu, Xiaoyong
experimental part, p. 322 - 330 (2012/04/04)
On the basis of the structure of heterocyclic-fused cis configuration derivatives and chain-opening neonicotinoids, two series of novel chain-opening tetrahydropyridine analogues were designed and synthesized. The preliminary bioassay tests were determined on cowpea aphid (Aphis craccivora) and armyworm (Pseudaletia separata Walker). The results showed that some of the target compounds exhibited repellent effects, whereas others showed good insecticidal activities.
Inhibitors for human glutaminyl cyclase by structure based design and bioisosteric replacement
Buchholz, Mirko,Hamann, Antje,Aust, Susanne,Brandt, Wolfgang,B?hme, Livia,Hoffmann, Torsten,Schilling, Stephan,Demuth, Hans-Ulrich,Heiser, Ulrich
experimental part, p. 7069 - 7080 (2010/05/02)
The inhibition of human glutaminyl cyclase (hQC) has come into focus as a new potential approach for the treatment of Alzheimer's disease. The hallmark of this principle is the prevention of the formation of Aβ 3,11(pE)-40,42, as these Aβ-speci
Synthesis and analgesic activity evaluation of some agmatine derivatives
He, Hongxia,Liu, Mengjia,Zheng, Zhibing,Liu, Ying,Xiao, Junhai,Su, Ruibin,Hu, Chun,Li, Jin,Li, Song
, p. 393 - 402 (2007/10/03)
A series of N,N′-disubstituted-2-nitroethene-1,1-diamine and N,N′-disubstituted-N″-cyanoguanidine derivatives were prepared and evaluated for in vivo analgesic activity. The blood brain barrier (BBB) VolSurf model was used to predict the BBB permeation profiles of our synthesized compounds. Some compounds show both remarkable analgesic activity and good BBB permeation profiles, and these compounds might be developed for treatment of opioid tolerance and dependence.
