623-66-5

Basic information

• Product Name: N-CAPRYLIC ANHYDRIDE
• Synonyms: N-OCTANOIC ANHYDRIDE;OCTANOIC ANHYDRIDE;N-CAPRYLIC ANHYDRIDE;caprylicanhydride(c8:0);Octanoic acid, anhydride;Caprylicanhydride;Bis(octanoic)anhydride;Biscaprylic anhydride
• CAS NO: 623-66-5
• Molecular Formula: C₁₆H₃₀O₃
• Molecular Weight: 270.41
• EINECS: 210-806-6
• Mol File: 623-66-5.mol
• Article Data: 16

Chemical Properties

• Melting Point: -1 °C
• Boiling Point: 180 °C / 20mmHg
• Flash Point: 142.4 °C
• Appearance: /
• Density: 0,91 g/cm3
• Vapor Pressure: 0.00334mmHg at 25°C
• Refractive Index: 1.4370 to 1.4390
• Storage Temp.: -20°C
• Stability: Moisture Sensitive
• CAS DataBase Reference: N-CAPRYLIC ANHYDRIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-CAPRYLIC ANHYDRIDE(623-66-5)
• EPA Substance Registry System: N-CAPRYLIC ANHYDRIDE(623-66-5)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-36/37/39-45
• RIDADR: 3265
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 623-66-5(Hazardous Substances Data)

Usage

General Description

N-Caprylic anhydride, also known as octanoic anhydride, is a chemical compound with the formula (C8H15O2)2O. It is an anhydride of caprylic acid, a fatty acid found in various plant and animal sources. This chemical is used in various industrial applications, such as the production of plastics, synthetic resins, textiles, and rubber. It is also used in the synthesis of organic compounds. N-Caprylic anhydride is a flammable liquid that must be handled with caution due to its potential to cause burns and serious eye damage.

InChI:InChI=1/C16H30O3/c1-3-5-7-9-11-13-15(17)19-16(18)14-12-10-8-6-4-2/h3-14H2,1-2H3

Upstream product

• 124-07-2 Octanoic acid 
• 108-24-7 acetic anhydride 
• 2388-12-7 peroxylaurinoic acid 
• 18229-29-3 8,9-dioxohexadecane 
• 64-18-6 formic acid 
• 111-64-8 n-octanoic acid chloride 
• 111-87-5 octanol 
• 767292-01-3 formic octanoic anhydride 
• 124-13-0 Octanal 
• 75-91-2 tert.-butylhydroperoxide 

Downstream Products

• 29430-22-6 17β-octanoyloxy-androst-4-en-3-one 
• 78993-06-3 4.4'-dioctanoyloxy-α.α'-diethyl-trans-stilbene 
• 818-23-5 8-Pentadecanon 
• 335-67-1 Perfluorooctanoic acid 
• 124-12-9 caprylnitrile 
• 4265-97-8 2-heptyl octanoate 
• 629-01-6 n-octanamide 
• 19670-49-6 monocaprylin 
• 99723-34-9 octanoic acid (2,4-dinitro-phenyl)-amide 
• 1028481-96-0 C₅₉H₈₂O₁₄ 
• 1028481-86-8 methyl 2-(11-methoxy-10,10-dimethyl-5,25-dimethylene-19-oxo-12-heptylcarbonyloxy-17-{[(phenylmethoxy)methoxy]ethyl}-21-(4-methoxybenzyloxy)-18,27,28,29-tetraoxatetracyclo[21.3.1.1^3,7.1^11,15]nonacosa-8-en-13-ylidene) acetate 
• 1401415-47-1 5'-deoxy-5'-[(N-methylcarbamoyl)amino]-2',3'-bis-O-octanoyl-N⁶-(N-phenylcarbamoyl)-adenosine 
• 37622-68-7 1-(2,4-dihydroxyphenyl)octan-1-one 
• 221637-71-4 3-benzyl-2-n-capryl-1-(16-(2'-tetrahydropyranyloxy)hexadecyl)-rac-glycerol 

Relevant articles and documents

One-pot electrochemical synthesis of acid anhydrides from alcohols

One-pot indirect electrochemical oxidation of alcohols in the methylene chloride–aqueous solution of sodium hydrocarbonate two-phase system in the presence of potassium iodide, 4-acetylamino-2,2,6,6-tetramethylpiperidin-1-oxyl, and 2,6-lutidine results in

Elucidation of the topography of the thapsigargin binding site in the sarco-endoplasmic calcium ATPase

Removal of each of the acyl groups of thapsigargin at O-3, O-8 and O-10 significant reduces the affinity of the inhibitors to the SERCA1a pump. Replacement of the acyl groups at O-3 and O-10 with flexible residues could be performed with only a minor decrease of the affinity, whereas introduction of voluminous stiff residues caused dramatic reduction of the affinity. The results can be rationalized on the basis of the interactions of thapsigargin with the SERCA1a pump as revealed from 3D X-ray structural models of thapsigargin bound to the SERCA1a. In conclusion the results confirm and elaborate the previously suggested pharmocophore model of thapsigargin.

Identification of a tunable site in bryostatin analogs: C20 bryologs through late stage diversification

The C20 region of our bryostatin analogs was identified as a nonpharmacophoric site that could be varied to tune analogs for function and physical properties without significantly affecting their binding affinity for PKC. The use of this site in a late-stage diversification strategy has enabled the facile synthesis of a variety of new C20 analogs, all of which retain nanomolar affinity for PKC, in agreement with our pharmacophore hypothesis.