623-71-2

Basic information

• Product Name: Ethyl 3-chloropropionate
• Synonyms: 3-CHLOROPROPIONIC ACID ETHYL ESTER;ETHYL 3-CHOOROCAETATE;Ethyl3-chloropropionate,98%;3-CHLOROPROPIONIC ACID ETHYL ESTER (BETA) 95+%;3-Chloropropionic acid ethyl;Ethyl 3-chloropropionate,96%;Ethyl 3-chloropropionate,99%;Ethyl 3-chloropropio
• CAS NO: 623-71-2
• Molecular Formula: C₅H₉ClO₂
• Molecular Weight: 136.58
• EINECS: 210-809-2
• Product Categories: C2 to C5;Carbonyl Compounds;Esters;API Intermediate
• Mol File: 623-71-2.mol

Chemical Properties

• Boiling Point: 162-163 °C(lit.)
• Flash Point: 130 °F
• Appearance: Colorless or light yellow liquid
• Density: 1.003 g/mL at 25 °C(lit.)
• Vapor Pressure: 2.21mmHg at 25°C
• Refractive Index: n20/D 1.425(lit.)
• Storage Temp.: Store below +30°C.
• Water Solubility: Immiscible
• BRN: 385698
• CAS DataBase Reference: Ethyl 3-chloropropionate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 3-chloropropionate(623-71-2)
• EPA Substance Registry System: Ethyl 3-chloropropionate(623-71-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-10
• Safety Statements: 26-36-37/39-16
• RIDADR: 3272
• WGK Germany: 3
• TSCA: Yes
• HazardClass: 3.2
• PackingGroup: III
• Hazardous Substances Data: 623-71-2(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
Ethyl 3-chloropropionate is used as a building block for the synthesis of various organic compounds. Its chloro group can be easily replaced by other functional groups, making it a valuable intermediate in the production of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
Ethyl 3-chloropropionate is used as a key intermediate in the synthesis of pharmaceutical compounds. Its ability to form a wide range of derivatives makes it a crucial component in the development of new drugs and medicines.
Used in Agrochemical Industry:
Ethyl 3-chloropropionate is used as a starting material for the production of various agrochemicals, such as pesticides and herbicides. Its reactivity and compatibility with other functional groups enable the creation of effective and targeted compounds for agricultural applications.
Used in Specialty Chemicals:
Ethyl 3-chloropropionate is used as a raw material in the production of specialty chemicals, including additives, coatings, and polymers. Its versatility in chemical reactions allows for the development of innovative and high-performance materials for various applications.

InChI:InChI=1/C5H9ClO2/c1-2-8-5(7)3-4-6/h2-4H2,1H3

Upstream product

• 542-76-7 3-Chloropropionitrile 
• 64-17-5 ethanol 
• 107-94-8 chloropropionic acid 
• 57-57-8 β-Propiolactone 
• 141-76-4 3-iodopropanoic acid 
• 871889-56-4 3-ethoxycarbonyloxy-propionitrile 
• 105-37-3 Ethyl propionate 
• 107-13-1 acrylonitrile 
• 814-68-6 acryloyl chloride 
• 625-36-5 2-chloropropionyl chloride 
• 140-88-5 ethyl acrylate 
• 74-85-1 ethene 
• 201230-82-2 carbon monoxide 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 19653-33-9 ethyl piperidine-1-propionate 
• 5439-14-5 3,4-dihydro-pyrido[1,2-a]pyrimidin-2-one 
• 617-65-2 Glutamic acid 
• 7195-71-3 3-(2-methyl-6-oxo-cyclohex-1-enyl)-propionic acid 
• 936-59-4 3-chloropropiophenone 
• 24626-27-5 3,3-diphenylallyl chloride 
• 131591-90-7 3-(6-ethoxycarbonyl-6-methyl-cyclohex-1-enyl)-propionic acid ethyl ester 
• 190271-89-7 1-phenyl-butane-1,2,4-tricarboxylic acid 
• 92329-81-2 (+/-)-cis-2-(2-ethoxycarbonyl-ethylamino)-cyclohexane-carboxylic acid-⁽¹⁾-ethyl ester 
• 2832-10-2 ethyl 4-acetyl-5-oxohexanoate 
• 58774-06-4 3-ethyl-1,5-dimethyl-3-cyanopentane-1,3,5-tricarboxylate 
• 763-69-9 ethyl 3-ethoxypropionate 
• 50463-83-7 ethyl 3-(1-pyrrolo)propanoate 
• 2275-26-5 3-(2-oxocyclohexyl)propionic acid 

Relevant articles and documents

Unprecedented alkylation of carboxylic acids by boron trifluoride etherate

The alkylation of carboxylic acids by an ethyl moiety of boron trifluoride etherate in the absence of ethyl alcohol from the reaction system is unexpected and novel. Both aromatic and aliphatic carboxylic acids were clearly alkylated affording good yields in short reaction times with the exception of nicotinic acid that necessitated an overnight reaction. It was noted that while ortho-substituted hydroxyl groups of carboxylic acids investigated were not affected by alkylation, those of meta- and para-substituted carboxylic acids were partially etherified. Furthermore, the alkylation reaction was found to be compatible with a range of functional groups such as halogens, amino and nitro groups except for the alkene function of undecylenic acid that underwent polymerisation with concomitant alkylation of its carboxylic acid function.

Preparation of esters of mono- or dicarboxylic non-aromatic and aromatic acids

The present invention relates to a method for preparing a carboxylic acid ester, wherein a carboxylic acid and/or a salt thereof is reacted with an alcohol in the presence of hydrogen chloride (HCl) and water to form the carboxylic acid ester, wherein the reaction is carried out using a starting reaction system wherein the molar ratio of HCl to carboxylic acid is at least 0.075 : 1 and the molar ratio of water to carboxylic acid is at least 0.25 : 1.

Convenient preparation of benzylseleno- and phenylselenoalkanoic acids: Reagents for synthesis of organoselenium compounds

An efficient and operationally simple route to benzylseleno- and phenylselenoalkanoic acids from ethyl benzyl/phenylselenoalkanoates is described. This involves preparation of ethyl benzyl/phenylselenoalkanoates as substrates by reaction of dibenzyl/diphenyl diselenide and sodium borohydride with ethyl chloroalkanoates in ethanol followed by basic hydrolysis and subsequent acidification. Copyright Taylor & Francis Group, LLC.

Condensed pyrimidine derivatives as inhibitors of foic acid-dependent enzymes

The invention relates to compounds of the formula I, useful as inhibitors of folic acid-dependent enzymes, or pharmaceutically acceptable salts thereof: wherein: Z= O or S; B=-NR 2 -, -CH 2 NR 2 -, -CH 2 CH 2 NR 2 -, -CH 2 CHR 7 - or -CH 2 O-, wherein R 2 is H or a C 1-3 alkyl, alkenyl or alkynyl group, and R 7 is H or a C 1-3 alkyl or alkoxy group; A= and n, R 3 , R 4 are defined as in the claims.

Chloropyridylcarbonyl derivatives

Novel chloropyridylcarbonyl derivatives of the formula STR1 in which Het is STR2 n is 1 or 2, R1 is hydrogen, optionally substituted C1-6 alkyl, optionally substituted C2-6 alkenyl, optionally substituted C3-6 alkynyl, optionally substituted phenyl or optionally substituted pyrimidinyl, and R2 and R3, independently of each other, are hydrogen or C1-4 alkyl, and acid addition salts and metal salt complexes thereof, are outstandingly active as microbicides.

Trimethylchlorosilane and water. Convenient reagents for the regioselective hydrochlorination of olefins

The hydrochlorination of a series of simple and functionalized olefins in high yields was readily accomplished using a mixture of trimethylchlorosilane and water. Hydrochlorination by this procedure is chemoselective and regioselective.

Aminomethylamide derivatives of (3-oxo-1,2-benzisothiazolin-2-yl)acetic acid and 3-(3-oxo-1,2-benzisothiazolin-2-yl)propionic acid

In the search for pharmacological active new derivatives of 1,2-benzisothiazolin-3-one amides of (3-oxo-1,2-benzisothiazolin-2-yl)acetic acid and 3-(3-oxo-1,2-benzisothiazolin-2-yl)propionic acid were obtained.In reaction of these amides with formaldehyde and various secondary amines the title compounds are formed.Morpholinmethylamide of (3-oxo-1,2-benzisothiazolin-2-yl)acetic acid showed activity against Trichomonas vaginalis.In the reaction of ethyl esters of (3-oxo-1,2-benzisothiazolin-2-yl)acetic- and -propionic acids with hydrazine hydrate products of ring-opening of isothiazole-2,2'-dithio-bis and 2,2'-dithio-bisN-(ethoxycarbonylethyl)benzamide are formed.