624-96-4

Basic information

• Product Name: 1,3-DICHLORO-3-METHYLBUTANE
• Synonyms: 1,3-DICHLORO-3-METHYLBUTANE;2,4-Dichloro-2-methylbutane;1,3-Dichloro-methylbutane
• CAS NO: 624-96-4
• Molecular Formula: C₅H₁₀Cl₂
• Molecular Weight: 141.04
• EINECS: 210-873-1
• Mol File: 624-96-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: -75.05°C (estimate)
• Boiling Point: 149.59°C (estimate)
• Flash Point: 36.4°C
• Appearance: /
• Density: 1.0718
• Vapor Pressure: 6.11mmHg at 25°C
• Refractive Index: 1.4442
• CAS DataBase Reference: 1,3-DICHLORO-3-METHYLBUTANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-DICHLORO-3-METHYLBUTANE(624-96-4)
• EPA Substance Registry System: 1,3-DICHLORO-3-METHYLBUTANE(624-96-4)

Safety Data

• Hazardous Substances Data: 624-96-4(Hazardous Substances Data)

Usage

Uses

1,3-Dichloro-3-methylbutane is used as a reagent in the synthesis of Precocene analogs which exhibit anti-juvenile hormone activity against Oxycarenus lavaterae.

InChI:InChI=1/C5H10Cl2/c1-5(2,7)3-4-6/h3-4H2,1-2H3

Upstream product

• 598-23-2 3-methyl-but-1-yne 
• 7647-01-0 hydrogenchloride 
• 78-79-5 isoprene 
• 60-29-7 diethyl ether 
• 1985-88-2 4-chloro-2-methyl-2-butanol 
• 763-32-6 2-methyl-1-buten-4-ol 
• 68-12-2 N,N-dimethyl-formamide 
• 98-88-4 benzoyl chloride 
• 7446-70-0 aluminium trichloride 
• 600-11-3 2,3-dichloropentane 
• 107-84-6 1-chloro-3-methylbutane 
• 78-78-4 methylbutane 
• 36441-29-9 14-phenyl-14H-dibenzo[a.j]xanthene 
• 74-85-1 ethene 

Downstream Products

• 2568-33-4 3-methyl-butane-1,3-diol 
• 1459-04-7 3-chloro-1,1-dimethyl-1-phenylpropane 
• 42514-50-1 1-hydroxy-3-methylbut-3-ylamine 
• 253185-03-4 tert-butylbenzene 
• 4481-30-5 2-methyl-3-phenylbutane 
• 107-84-6 1-chloro-3-methylbutane 
• 101437-85-8 1,4-bis-(3-chloro-1,1-dimethyl-propyl)-benzene 
• 64277-90-3 [2-(1,1-Dimethyl-3-phenylamino-propyl)-phenyl]-phenyl-methanone 
• 64277-88-9 5-Benzoyl-1,1-dimethylindan 
• 64277-89-0 5,5-dimethyl-1,2-diphenyl-2,3,4,5-tetrahydro-1H-benzo[c]azepine 
• 5205-07-2 3-methyl-3-buten-1-yl acetate 
• 78-79-5 isoprene 
• 15936-45-5 N-prenylphthalimide 
• 2855-08-5 1-chloro-3,3-dimethylbutane 

Relevant articles and documents

Formamides as Lewis Base Catalysts in SNReactions—Efficient Transformation of Alcohols into Chlorides, Amines, and Ethers

A simple formamide catalyst facilitates the efficient transformation of alcohols into alkyl chlorides with benzoyl chloride as the sole reagent. These nucleophilic substitutions proceed through iminium-activated alcohols as intermediates. The novel method, which can be even performed under solvent-free conditions, is distinguished by an excellent functional group tolerance, scalability (>100 g) and waste-balance (E-factor down to 2). Chiral substrates are converted with excellent levels of stereochemical inversion (99 %→≥95 % ee). In a practical one-pot procedure, the primary formed chlorides can be further transformed into amines, azides, ethers, sulfides, and nitriles. The value of the method was demonstrated in straightforward syntheses of the drugs rac-Clopidogrel and S-Fendiline.