6284-40-8Relevant articles and documents
Method for synthesizing meglumine through catalytic hydrogenation by taking ammonia borane as hydrogen source
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Paragraph 0020-0022; 0025, (2018/10/19)
The invention discloses a method for synthesizing meglumine through catalytic hydrogenation by taking ammonia borane as a hydrogen source, and belongs to the technical field of chemical drug synthesis. The method comprises the step that on the basis that glucose-methylamine schiff base is synthesized by taking glucose and methylamine as raw materials, and by taking ammonia borane as the hydrogen source for performing catalytic hydrogenation, the meglumine is synthesized. Compared with a method in the past, the method has the advantages of being mild in catalytic hydrogenation reaction, safe and high yield.
Low-Temperature Reductive Aminolysis of Carbohydrates to Diamines and Aminoalcohols by Heterogeneous Catalysis
Pelckmans, Michiel,Vermandel, Walter,Van Waes, Frederik,Moonen, Kristof,Sels, Bert F.
, p. 14540 - 14544 (2017/10/23)
Short amines, such as ethanolamines and ethylenediamines, are important compounds in today's bulk and fine chemicals industry. Unfortunately, current industrial manufacture of these chemicals relies on fossil resources and requires rigorous safety measures when handling explosive or toxic intermediates. Inspired by the elegant working mechanism of aldolase enzymes, a novel heterogeneously catalyzed process—reductive aminolysis—was developed for the efficient production of short amines from carbohydrates at low temperature. High-value bio-based amines containing a bio-derived C2 carbon backbone were synthesized in one step with yields up to 87 C%, in the absence of a solvent and at a temperature below 405 K. A wide variety of available primary and secondary alkyl- and alkanolamines can be reacted with the carbohydrate to form the corresponding C2-diamine. The presented reductive aminolysis is therefore a promising strategy for sustainable synthesis of short, acyclic, bio-based amines.
Mixed Sugar Compositions
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Paragraph 0207, (2014/09/29)
Novel mixtures of sugar amides or sugar amines are disclosed that have improved thermal properties over the individual components. New feedstocks based on both the surfactant tail as well as the sugar head group allow for improved physical properties of sugar amide surfactant mixtures and thus improved formulatability. Furthermore, new sources of unique methyl esters from both bioengineering and or co-metathesis of fats and oils provide novel and improved sugar amide surfactant mixtures.
An efficient renewable-derived surfactant for aqueous esterification reactions
Rajabi, Fatemeh,Luque, Rafael
, p. 5152 - 5155 (2014/01/23)
An efficient and simple approach for the aqueous esterification of a range of carboxylic acids with alcohols has been developed using catalytic amounts of a glucose-derived N-alkanoyl-N-methyl-1-glycamine non-ionic biosurfactant (C12MG). Excellent yields to final products were obtained under mild conditions and the protocol was amenable to both aromatic and long alkyl chain acids (e.g. fatty acids).
Composition and Tablet Comprising Raltegravir
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, (2012/12/14)
The present invention relates to a composition and tablet comprising raltegravir and to a process for the preparation of such tablet.
Water-soluble porphyrin derivatives for photodynamic therapy, their use and manufacture
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, (2008/06/13)
High purity pharmaceutical-grade water-soluble porphyrin derivatives given by formula 1 or 2 in the specification, and new methods to prepare and use such porphyrin derivatives are disclosed. A preferred method comprises the steps of one- or two-step direct acidic alcoholysis of biological raw material producing a crystalline alkyl pheophorbide, conversion of the obtained alkyl pheophorbide into an acidic porphyrin, and reaction of the acidic porphyrin in water or in an aqueous organic solution with a hydrophilic organic amine. Another preferred method comprises reaction of acidic porphyrins prepared in water or in aqueous organic solution with a hydrophilic organic amine. Another preferred method comprises the additional step of purification of the resultant water-soluble porphyrin derivative by reversed phase chromatography using volatile solvents. The disclosed compounds are useful as photosensitizers for the photodynamic therapy of cancer, infectious and other diseases as well as for light irradiation treatments in other cases.
Water-soluble porphyrin derivatives for photodynamic therapy, their use and manufacture
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, (2008/06/13)
High purity pharmaceutical-grade water-soluble porphyrin derivatives having a general formula given by formula 1 or 2 and new methods to prepare and use such porphyrin derivatives: Wherein B is a ring having the structure: Wherein: R1═—CH═CH2, —CH(OAlk)CH3, —CHO, —C(O)CH3, —CH2CH3, —CH(Alk)CH(COAlk)2, —CH2CH(COAlk)2, —CH(Alk)CH2COAlk, —CH(Alk)CH2CH(OH)CH3, and —CH2CH2CH(OH)CH3 R2═—CH3, —CHO, —CH(OH)Alk, —CH═CHAlk, CH2OH, and CH2OAlk; R3═—OH, —OAlk, —NH-Alk, NH—X—COO?(HG)+, —NH—Y—NR8R9, -and NH—Y—OH; R4═—OAlk, —NH-Alk, and NH—X—COO?(HG)+; R5═—OAlk, —NH-Alk, and NH—X—COO?(HG)+; R6═H and —COOAlk; R7═—O?(HG)+, —OAlk, —NH-Alk, and —NH—X—COO?(HG)+; R8═H and Alk R9═H and Alk Wherein: —NH—X—COO?=the residue of organic amino acid; X=alkylidene, peptides, oligopeptides and —(CH2CH2O)nCH2CH2—, wherein n=1-30; Y=alkylidene and —(CH2CH2O)nCH2CH2—, wherein n=1-30; G=a hydrophilic organic amine (fex. N-methyl-D-glucamine and other amino-group containing carbohydrate derivatives, TRIS, amino acids, oligopeptides); and Alk=an alkyl substituent. An embodiment of the present invention consists of a method to prepare water-soluble porphyrin derivatives comprising the steps of one- or two-step direct acidic alcoholysis of biological raw material producing a crystalline alkyl pheophorbide, conversion of the obtained alkyl pheophorbide into an acidic porphyrin, and reaction of the acidic porphyrin in water or in an aqueous organic solution with a hydrophilic organic amine. Another embodiment of the present invention consists of a method to prepare water-soluble porphyrin derivatives, comprising reaction of acidic porphyrins prepared by any known method in water or in aqueous organic solution with a hydrophilic organic amine. Another embodiment of the present invention comprises the additional step of purification of the resultant water-soluble porphyrin derivative by reversed phase chromatography using volatile solvents. The compound disclosed in the present invention can be used as photosensitizers for the photodynamic therapy of cancer, infectious and other diseases as well as for light irradiation treatments in other cases.
Beta-lactams having an alkyl-substituted side chain
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, (2008/06/13)
Taxane derivatives having an alkyl substituted C13 side chain.
Process for the preparation of N-alkypolyhydroxyalkylamines from monoalkylamine and reducing sugar
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Page column 4-5, (2008/06/13)
Aqueous, alcoholic or aqueous-alcoholic solutions of a monoalkylamine and a reducing sugar are simultaneously injected into a mixing unit and the two solutions are mixed under turbulence in the mixing unit for 6 seconds to 5 minutes at a temperature of 25 to 60° C. and a pressure of 50 to 90 bar. The mixture is then added to a hydrogenation reactor and hydrogenated with hydrogen in the presence of a hydrogenation catalyst. An alkylpolyhydroxyalkylamine is obtained in high yield and with high purity.
Chelated complexes of paramagnetic metals with low toxicity
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, (2008/06/13)
Compounds of formulae (I) and (II) wherein the R, R1, R2, R3 and R4 groups have the meanings defined in the disclosure, are useful chelants for metal ions. The complexes of compounds (I) and (II) with paramagnetic ions are useful as contrast agents for M.R.I. imaging.
