69172-20-9Relevant articles and documents
Enantioselective total synthesis of ligraminol d and ligraminol e
Kumbhar, D. D.,Mane, Baliram B.,Waghmode, Suresh B.
, p. 2285 - 2289 (2019/12/11)
As a part of our ongoing research on the synthesis of bioactive constituents or molecules by using an organocatalytic approach, enantioselective total syntheses of ligraminol D and ligraminol E were achieved starting from a commercially available nonchiral aldehyde. Key steps in this synthesis were an asymmetric α-aminoxylation of an aldehyde and a Mitsunobu reaction.
An Efficient Enantioselective Synthesis of Natural Gingerols, the Active Principles of Ginger
Ramesh Reddy,Wadavrao, Sachin B.,Yadav,Venkat Narsaiah
, p. 1009 - 1017 (2015/11/23)
A straightforward synthesis of (S)-gingerols 1-3 has been described. The requisite stereogenic center in the target molecules was introduced by Sharpless asymmetric dihydroxylation using a chiral complex, AD-mix β. This route is simple and efficient to prepare the products in very good yields.
A natural product inspired tetrahydropyran collection yields mitosis modulators that synergistically target CSE1L and tubulin
Voigt, Tobias,Gerding-Reimers, Claas,Tran, Tuyen Thi Ngoc,Bergmann, Sabrina,Lachance, Hugo,Sch?lermann, Beate,Brockmeyer, Andreas,Janning, Petra,Ziegler, Slava,Waldmann, Herbert
supporting information, p. 410 - 414 (2013/02/23)
A Prins cyclization between a polymerbound aldehyde and a homoallylic alcohol served as the key step in the synthesis of tetrahydropyran derivatives. A phenotypic screen led to the identification of compounds that inhibit mitosis (as seen by the accumulation of round cells with condensed DNA and membrane blebs; see picture). These compounds were termed tubulexins as they target the CSE1L protein and the vinca alkaloid binding site of tubulin.
