72-43-5

Basic information

• Product Name: 2,2-Bis(p-methoxyphenol)-1,1,1 -trich loroethane
• Synonyms: Ethane,1,1,1-trichloro-2,2-bis(p-methoxyphenyl)- (8CI);1,1,1-Trichloro-2,2-bis(4-methoxyphenyl)ethane;1,1,1-Trichloro-2,2-bis(p-methoxyphenyl)ethane;1,1,1-Trichloro-2,2-di(4-methoxyphenyl)ethane;1,1-Bis(p-methoxyphenyl)-2,2,2-trichloroethane;2,2,2-Trichloro-1,1-bis(4-methoxyphenyl)ethane;2,2-Bis(4-methoxyphenyl)-1,1,1-trichloroethane; 2,2-Bis(p-methoxyphenyl)-1,1,1-trichloroethane;2,2-Di-p-anisyl-1,1,1-trichloroethane;4,4'-(2,2,2-Trichloroethylidene)dianisole; DMDT;Di(p-methoxyphenyl)(trichloromethyl)methane; Dimethoxy-DDT; Marlate; Mesox K;Methoxcide; Methoxy-DDT; Methoxychlor; Metox; Metox plynny; Mezox K; NSC 8945;p,p'-DMDT; p,p'-Dimethoxydiphenyltrichloroethane; p,p'-Methoxychlor
• CAS NO: 72-43-5
• Molecular Formula: C₁₆H₁₅Cl₃O₂
• Molecular Weight: 345.66
• EINECS: 200-779-9
• Mol File: 72-43-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: greater than or equal to 100 °C.
• Flash Point: less than 60 degrees C
• Appearance: COLOURLESS TO LIGHT YELLOW CRYSTALS , WITH CHARACTERISTIC ODOUR.
• Density: 1.4 g/cm3
• Vapor Pressure: 2.1E-07mmHg at 25°C
• Refractive Index: 1.57
• CAS DataBase Reference: 2,2-Bis(p-methoxyphenol)-1,1,1 -trich loroethane(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-Bis(p-methoxyphenol)-1,1,1 -trich loroethane(72-43-5)
• EPA Substance Registry System: 2,2-Bis(p-methoxyphenol)-1,1,1 -trich loroethane(72-43-5)

Safety Data

• Hazardous Substances Data: 72-43-5(Hazardous Substances Data)

Usage

General Description

2,2-Bis(p-methoxyphenol)-1,1,1-trichloroethane, also known as methoxychlor, is a synthetic organic compound used primarily as an insecticide. It is a white to off-white crystalline solid with a slight odor. Methoxychlor acts as a contact and stomach poison, disrupting the nervous system of insects and causing paralysis and ultimately death. It was commonly used in agricultural and household pest control applications, but its use has been greatly restricted due to its potential negative effects on human health and the environment. Methoxychlor has been classified as a possible human carcinogen by the International Agency for Research on Cancer and as an endocrine disruptor, being toxic to reproductive and developmental health in humans and wildlife. Despite its restrictions, methoxychlor is still used in some countries for specific agricultural purposes.

InChI:InChI=1/C16H15Cl3O2/c1-20-13-7-3-11(4-8-13)15(16(17,18)19)12-5-9-14(21-2)10-6-12/h3-10,15H,1-2H3

Upstream product

• 75-87-6 chloral 
• 100-66-3 methoxybenzene 
• 14337-31-6 2,2,2-trichloro-1-(4-methoxyphenyl)ethan-1-ol 
• 50-29-3 p,p'-DDT 
• 109-89-7 diethylamine 
• 4563-33-1 phenyl-methanesulfonic acid amide 
• 90348-89-3 phenyl-N-(2,2,2-trichloroethylidene)methanesulfonamide 
• 108-88-3 toluene 
• 63636-97-5 N,N-dichlorophenylmethanesulfonamide 
• 123-11-5 4-methoxy-benzaldehyde 
• 7446-70-0 aluminium trichloride 
• 2971-36-0 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 7388-31-0 1,1-dichloro-2,2-bis(p-methoxyphenyl)ethane 
• 90-96-0 bis(p-methoxyphenyl)methanone 
• 2132-70-9 1,1-dichloro-2,2-bis(p-methoxyphenyl)ethylene 
• 5359-41-1 methyl ester of 2,2-bis(4,4'-dimethoxyphenyl)ethanoic acid 
• 1449216-36-7 N,N-diethyl-2,2-bis(4-methoxyphenyl)acetamide 
• 76174-76-0 1,1,4,4-tetrakis(4-methoxyphenyl)-2,2,3,3-tetrachlorobutane 
• 89264-24-4 1,1,1-trichloro-2,2-bis(4-methoxy-3-nitrophenyl)ethane 
• 79622-61-0 1,1,1-trichloro-2,2-bis(3-bromo-4-methoxyphenyl)ethane 
• 76174-75-9 1,1,4,4-tetrakis(4-methoxyphenyl)-2,3-dichlorobut-2-ene 
• 2132-62-9 4,4'-dimethoxydiphenylacetylene 
• 4705-34-4 4,4'-dimethoxystilbene 
• 4957-05-5 1,1'-(2-chloroethane-1,1-diyl)bis(4-methoxybenzene) 
• 4356-69-8 1,1-bis-(4-methoxyphenyl)ethylene 
• 10543-21-2 1,1-bis(4-methoxyphenyl)ethane 

Relevant articles and documents

Aerobic Electrochemical Transformations of DDT to Oxygen-Incorporated Products Catalyzed by a B12 Derivative

Electrochemical transformations of DDT into oxygen-incorporated products, amides and esters, catalyzed by a B12 derivative, heptamethyl cobyrinate perchlorate, have been developed under aerobic conditions. The dechlorinative oxygenation of DDT forms the acyl chloride as an intermediate for the synthesis of the amide and ester in the reaction with the amine and alcohol, respectively. This electrochemical method demonstrated with 20 oxygen-incorporated dechlorinated products up to 88% yields with 15 new compounds and was also successfully applied to the conversion of methoxychlor to an amide and ester.

New synthetic approach to phenylmethanesulfonamide derivatives on the basis of Phenyl-N-(2,2,2-trichloroethylidene)-methanesulfonamide

The reaction of N,N-dichlorophenylmethanesulfonamide with trichloroethylene gave a new representative of highly electrophilic N-sulfonyl-substituted polyhalogenated aldehyde imines, phenyl-N-(2,2,2-trichloroethylidene) methanesulfonamide. High reactivity of the product was demonstrated by alkylation of toluene, anisole, thiophene, and 2-chlorothiophene. Pleiades Publishing, Ltd., 2012.

Physical, chemical, and isotopic (atomic) labels

Chemical or isotopic labels are added to, e.g., a potentially lethal drug formulation, to generate a unique chemical fingerprint. Combinations of chemical additives are mixed with the drug to aid in their isolation and identification, especially when such drugs are used for illicit purposes. When stable isotopes are incorporated into lethal drugs, the labeling process conveys a very unique internal chemical signature and greatly aids in the identification of the parent drug in body fluids and tissues. When heath-care providers become aware that certain drugs can now be easily tracked and identified in a victim, individuals may be reluctant to utilize these agents for ill purposes.