7238-62-2

Basic information

• Product Name: ETHYL 2-CHLORO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE
• Synonyms: ETHYL 2-CHLORO-4-METHYLTHIAZOLE-5-CARBOXYLATE;ETHYL 2-CHLORO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE;Ethyl 2-chloro-4-methyl-1,3-thiazole-5-carboxylate 97%;2-Chloro-4-methyl-5-thiazolecarboxylic acid ethyl ester;Ethyl 2-chloro-4-methyl-1,3-thiazole-5-carboxylate ,97%;2-Chloro-4-methyl-5-ethoxycarbonylthiazole;2-Chloro-4-methylthiazole-5-carboxylic acid ethyl ester
• CAS NO: 7238-62-2
• Molecular Formula: C₇H₈ClNO₂S
• Molecular Weight: 205.66
• EINECS: 604-604-1
• Mol File: 7238-62-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: 46 °C
• Boiling Point: 116℃
• Flash Point: 277.9°C
• Appearance: /
• Density: 1.51g/cm³
• Vapor Pressure: 2.56E-12mmHg at 25°C
• Refractive Index: 1.656
• PKA: -0.10±0.10(Predicted)
• CAS DataBase Reference: ETHYL 2-CHLORO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-CHLORO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE(7238-62-2)
• EPA Substance Registry System: ETHYL 2-CHLORO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE(7238-62-2)

Safety Data

• Hazardous Substances Data: 7238-62-2(Hazardous Substances Data)

Usage

General Description

ETHYL 2-CHLORO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE is a chemical compound that falls under the category of organo-sulfur compounds, specifically a thiazole. Thiazole compounds feature a five-membered ring that contains a nitrogen atom, a sulfur atom and three carbon atoms. This chemical compound, with its distinctive 2-Chloro-4-methyl-1,3-thiazole-5-carboxylic acid ethyl ester structure, is mainly known and used for its role as a chemical intermediate, playing a crucial part in several methods of organic synthesis. The exact properties of ETHYL 2-CHLORO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE, such as its melting point, boiling point, and molecular weight, may vary but are defined in accordance with standard practices in chemistry. The compound plays a key role in chemical applications and research, although data regarding its potential toxicity or environmental impact might be limited.

InChI:InChI=1/C11H17ClN4O3/c12-6-9(17)7-15-8-13-10(16(18)19)11(15)14-4-2-1-3-5-14/h8-9,17H,1-7H2

Upstream product

• 40235-78-7 4-methyl-2-thiazolone-5-carboxylic acid ethyl ester 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 
• 540-80-7 tert.-butylnitrite 
• 7210-76-6 ethyl-2-amino-4-methylthiazole-5-carboxylate 
• 7732-18-5 water 
• 626-34-6 ethyl aminocrotonate 
• 17309-13-6 ethyl 4-methyl-2-thioxo-2,3-dihydro-1,3-thiazole-5-carboxylate 
• 100616-27-1 2-[5-(2-hydroxy-ethyl)-4-methyl-thiazol-2-ylmercapto]-4-methyl-thiazole-5-carboxylic acid ethyl ester 
• 109-99-9 tetrahydrofuran 
• 56355-41-0 2-chloro-4,5-dimethyl-1,3-thiazole 
• 100135-25-9 2-(4,5-dimethyl-thiazol-2-ylmercapto)-4-methyl-thiazole-5-carboxylic acid ethyl ester 

Downstream Products

• 122945-79-3 3-Methyl-4-oxo-4H-1,9-dithia-3a,10-diaza-cyclopenta[b]fluorene-2-carboxylic acid ethyl ester 
• 122945-80-6 3-Methyl-4-oxo-5,6,7,8-tetrahydro-4H-1,9-dithia-3a,10-diaza-cyclopenta[b]fluorene-2-carboxylic acid ethyl ester 
• 122945-77-1 3-Methyl-5-oxo-7-phenyl-5H-thiazolo[3,2-a]thieno[2,3-d]pyrimidine-2-carboxylic acid ethyl ester 
• 122945-83-9 1-Methyl-10-oxo-10H-3,9-dithia-4,10a-diaza-cyclopenta[b]fluorene-2-carboxylic acid ethyl ester 
• 122945-82-8 2-(4-Chloro-phenyl)-7-methyl-9-oxo-9H-thiazolo[3,2-a]thieno[3,2-d]pyrimidine-6-carboxylic acid ethyl ester 
• 122945-81-7 7-Methyl-9-oxo-2-phenyl-9H-thiazolo[3,2-a]thieno[3,2-d]pyrimidine-6-carboxylic acid ethyl ester 
• 72850-83-0 2-(2,4-dichloro-phenoxy)-4-methyl-thiazole-5-carboxylic acid ethyl ester 
• 1094342-50-3 3-chloro-5-{[6-chloro-2-fluoro-3-({5-[4-methyl-2-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-1,3-thiazol-5-yl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile 
• 1094342-52-5 3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile 
• 1215002-61-1 ethyl 3-(2-chloro-4-methylthiazol-5-yl)-3-oxopropanoate 
• 141-97-9 ethyl acetoacetate 
• 40003-15-4 ethyl 4-methyl-2-phenylsulfanylthiazole-5-carboxylate 
• 40003-12-1 4-methyl-2-phenoxy-thiazole-5-carboxylic acid ethyl ester 
• 40003-48-3 2-chloro-4-methylthiazole-5-carboxylic acid 

Relevant articles and documents

AMINOPHENYLCYCLOPROPYL CARBOXYLIC ACIDS AND DERIVATIVES AS AGONISTS TO GPR40

The present invention relates generally to novel therapeutic compounds and more particularly to novel compounds, their use as GPR40 agonists, processes for their manufacture, and intermediates useful in their preparation.

One pot synthesis of 1,2,4-triazoles

One pot synthesis of 1,2,4-triazoles uses thioimidate intermediate and 1,2-dichloroethane solvent.

Syntheses and Reactions of 2-Halo-5-thiazolecarboxylates

A variety of 2-halo-5-thiazolecarboxylates was prepared from substituted-3-aminoacrylates and 3-ketoesters.Selective reduction of 2-chloro-5-thiazolecarboxylates 4a, 4i and 4j with sodium borohydride in ethanol provided the corresponding 2-halo-5-thiazolemethanols 27 - 29.Nucleophilic displacement on methyl methanesulfonate (32c) occured selectivity at the 5-substituent to provide 2-chloro-4-(trifluoromethyl)-5-(heteroatom-substituted methyl)thiazoles 32d-f.