7689-50-1

Basic information

• Product Name: Benzylaminoacetic acid hydrochloride
• Synonyms: BZL-GLY-OH;BENZYLAMINO-ACETIC ACID;(N-BENZYLAMINO)ACETIC ACID;N-BZL-GLY-OH;N-ALPHA-BENZYL-GLYCINE;1-Benzyl glycine hydrochloride;Bzl-Gly-OH•Bz-Gly-OH·HCl
• CAS NO: 7689-50-1
• Molecular Formula: C₉H₁₂NO₂*Cl
• Molecular Weight: 201.65
• Product Categories: Amino Acids Derivatives;Glycine [Gly, G];Amino Acids and Derivatives;Amino hydrochloride;Amino Acid Derivatives;Glycine;Peptide Synthesis
• Mol File: 7689-50-1.mol

Chemical Properties

• Melting Point: 232 °C (dec.)(lit.)
• Boiling Point: 308.9 °C at 760 mmHg
• Flash Point: 140.6 °C
• Appearance: crystalline
• Vapor Pressure: 0.000285mmHg at 25°C
• Storage Temp.: Store at RT.
• BRN: 3915652
• CAS DataBase Reference: Benzylaminoacetic acid hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Benzylaminoacetic acid hydrochloride(7689-50-1)
• EPA Substance Registry System: Benzylaminoacetic acid hydrochloride(7689-50-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 7689-50-1(Hazardous Substances Data)

Usage

Chemical Properties

Crystalline

InChI:InChI=1/C9H11NO2.ClH/c11-9(12)7-10-6-8-4-2-1-3-5-8;/h1-5,10H,6-7H2,(H,11,12);1H

Upstream product

• 20158-69-4 2-(N-benzyl-4-methylphenylsulfonamido)acetic acid 
• 64-19-7 acetic acid 
• 86731-89-7 N-benzyl-N-formyl-glycine 
• 100-46-9 benzylamine 
• 197958-49-9 N-benzyl-N-(toluene-4-sulfonyl)-glycine ethyl ester 
• 6436-90-4 ethyl 2-(benzylamino)acetate 
• 105-36-2 ethyl bromoacetate 
• 100-52-7 benzaldehyde 
• 56-40-6 glycine 

Downstream Products

• 70420-10-9 [Benzyl-(hydroxy-trichloromethyl-phosphinoylmethyl)-amino]-acetic acid 
• 126227-24-5 2-piperidinylethyl-N-benzyl-N-hydroxycarbonylmethyl-aminomethyl-phosphinic acid 
• 52558-39-1 N-benzyl-N-phosphonomethyl-glycine 
• 76315-01-0 N-benzyl-N-(tert-butoxycarbonyl)glycine 
• 6344-41-8 2-(benzyl(nitroso)amino)acetic acid 
• 71922-59-3 N-benzyl-N-benzyloxycarbonyl-glycine 
• 333968-47-1 N-benzyl-{4-[3,5-bis(tert-butyldimethylsilyloxy)-2-[3-(tert-butyldimethylsilyloxy)-4-phenoxybutyl]cyclopentyl]butylamino}acetic acid 

Relevant articles and documents

Discovery of seneciobipyrrolidine derivatives for the amelioration of glucose homeostasis disorders through 4E-BP1/Akt/AMPK signaling activation

Modulating the glucose transport in skeletal muscle is a promising strategy for ameliorating glucose homeostasis disorders. However, the complicated mechanisms of glucose transport make it difficult to find compounds therapeutically relevant molecular mechanisms of action, while phenotypic screening is thought to be an alternative approach to mimic the cell state of interest. Here, we report (±)-seneciobipyrrolidine (1a) is first found to enhance glucose uptake in L6 myotubes through phenotype-based screening. Further SAR investigation led to the identfication of compound A27 (EC50 = 2.7 μM). Proteomiic analysis discloses the unique function mechanism of A27 through upregulating the level of the eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1), subsequently enhancing the Akt and AMPK phosphorylation, thereby promoting the glucose uptake. Chronic oral administration of A27 significantly lowers blood glucose and improves glucose tolerance in db/db mice. This work is new research on seneciobipyrrolidine derivatives, providing a promising avenue for ameliorating glucose homeostasis.

Structure-property relationship study of n-(hydroxy)peptides for the design of self-assembled parallel β-sheets

The design of novel and functional biomimetic foldamers remains a major challenge in creating mimics of native protein structures. Herein, we report the stabilization of a remarkably short β-sheet by incorporating N-(hydroxy)glycine (Hyg) residues into the backbone of peptides. These peptide- peptoid hybrids form unique parallel β-sheet structures by selfassembly upon hydrogenation. Our spectroscopic and crystallographic data suggest that the local conformational perturbations induced by N-(hydroxy)amides are outweighed by a network of strong interstrand hydrogen bonds.

A mild and efficient method for the one-pot monocarboxymethylation of primary amines

A mild and efficient method for the monocarboxymethylation of primary amines that takes place under aqueous conditions at room temperature is described. Treatment of an aqueous solution of a variety of primary amines with two equivalents of glyoxylic acid

Polypeptide having an amino acid replaced with N-benzylglycine

The present invention relates to one or more polypeptides having useful biological activity in a mammal, which comprise:a polypeptide related to bradykinin of four to ten amino acid residues wherein one or more specific amino acids in the polypeptide chai