97-95-0 Usage
Chemical Properties
Ethylbutanol is a colorless liquid with a mild,
alcoholic odor.
Uses
Different sources of media describe the Uses of 97-95-0 differently. You can refer to the following data:
1. It is used as a perfuming agent in cosmetics industry. 2-Ethyl-1-butanol is used for the synthesis of various pharmaceutical compounds, such as novel branched Alkyl carbamates, acting as anticonvulsant agent. It is also a solvent used for various organic synthesis, separation processes and ionic liquids, and solvent mixtures for pharmaceutical applications . It is also used to make penetrating oils, corrosion inhibitors, plasticizers, and perfumes; as cleaning agent for printed circuits; and to improve flow of paints and varnishes.
2. Solvent for oils, resins, waxes, dyes; diluent;
synthesis of perfumes, drugs; flavoring.
Production Methods
2-Ethylbutanol can be prepared commercially by the aldol
condensation of acetaldehyde and 1-butanal and subsequent
hydrogenation.
General Description
Flash point of 137°F. Less dense than water and slightly soluble in water. Vapors are heavier than air. Used as a solvent and in the manufacture of pharmaceuticals.
Reactivity Profile
Flammable and/or toxic gases are generated by the combination of alcohols, such as 2-ETHYL-1-BUTANOL, with alkali metals, nitrides, and strong reducing agents. Alcohols react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.
Health Hazard
Liquid causes eye burns. Vapors may be mildly irritating to nose and throat.
Fire Hazard
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Safety Profile
Moderately toxic by
ingestion and sktn contact. A skin and
severe eye irritant. Flammable liquid when
exposed to heat or flame; can react with
oxidizing materials. To fight fire, use dry
chemical, CO2, foam, fog. When heated to
decomposition it emits acrid smoke and
irritating fumes. See also ALCOHOLS.
Potential Exposure
Used as a solvent; for making dyes,
perfumes, flavorings, and drugs
Shipping
UN2275 Ethylbutanol, Hazard Class: 3; Labels:
3-Flammable liquid
Purification Methods
Dry it with CaSO4 for several days, filter and fractionally distil it. [Beilstein 1 IV 1725.]
Incompatibilities
May form explosive mixture with air.
Incompatible with oxidizers, strong acids; caustics, isocyanates, amines, isocyanates.
Waste Disposal
Incineration by spraying or in
paper packaging. Flammable solvent may be added.
Check Digit Verification of cas no
The CAS Registry Mumber 97-95-0 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 9 and 7 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 97-95:
(4*9)+(3*7)+(2*9)+(1*5)=80
80 % 10 = 0
So 97-95-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H14O/c1-3-6(4-2)5-7/h6-7H,3-5H2,1-2H3
97-95-0Relevant articles and documents
Iridium-Catalyzed Domino Hydroformylation/Hydrogenation of Olefins to Alcohols: Synergy of Two Ligands
Beller, Matthias,Huang, Weiheng,Jackstell, Ralf,Jiao, Haijun,Tian, Xinxin
supporting information, (2022/01/13)
A novel one-pot iridium-catalyzed domino hydroxymethylation of olefins, which relies on using two different ligands at the same time, is reported. DFT computation reveals different activities for the individual hydroformylation and hydrogenation steps in the presence of mono- and bidentate ligands. Whereas bidentate ligands have higher hydrogenation activity, monodentate ligands show higher hydroformylation activity. Accordingly, a catalyst system is introduced that uses dual ligands in the whole domino process. Control experiments show that the overall selectivity is kinetically controlled. Both computation and experiment explain the function of the two optimized ligands during the domino process.
Upgrading of Ethanol to n-Butanol via a Ruthenium Catalyst in Aqueous Solution
Dibenedetto, Tarah A.,Jones, William D.
supporting information, p. 1884 - 1888 (2021/06/30)
The upgrading of ethanol to n-butanol via the Guerbet reaction in aqueous media has been developed. This system allows for the upgrading of ethanol to n-butanol in up to a 28% yield and 57% selectivity, at only 80 °C. This system is also able to tolerate the same feedstock ratio found in fermentation broth (water to ethanol ratio of 90:10), albeit a decrease in yield and selectivity (20% yield of n-butanol, 48% selectivity). Smaller amounts of longer-chain alcohols are also formed.
Preparation method of remdesivir intermediate 2-ethyl-1-butanol
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Paragraph 0055-0056, (2020/08/09)
The invention relates to a preparation method of a remdesivir intermediate 2-ethyl-1-butanol. The preparation method comprises a step of substitution reaction, namely a step of carrying out a substitution reaction on alkyl acetoacetate and halogenated ethane under an alkaline condition to obtain alkyl 2-ethyl-3-oxo-butyrate; a step of addition reduction, namely a step of carrying out an addition reduction reaction on the alkyl 2-ethyl-3-oxo-butyate to obtain alkyl 2-ethylbutyrate; a step of reduction, namely a step of subjecting the alkyl 2-ethylbutyrate to a reduction reaction to prepare 2-ethyl-1-butanol (I). According to the preparation method of the remdesivir intermediate 2-ethyl-1-butanol, the alkyl acetoacetate and halogenated ethane serve as main raw materials, the raw materials are simple and easy to obtain, the 2-ethyl-1-butanol (I) is prepared through substitution reaction, addition reduction and reduction reaction, the process is simple, economical and environmentally friendly, the product is convenient to obtain, and industrial production of remdesivir bulk drugs is facilitated.
Xn:Harmful;
