99365-40-9

Basic information

• Product Name: 6-Bromo-1,3-dihydro-2H-indol-2-one
• Synonyms: 6-BROMO-1,3-DIHYDRO-INDOL-2-ONE;6-BROMO-2-OXYINDOLE;6-BROMO-2-OXINDOLE;6-BROMOOXINDOLE;2H-INDOL-2-ONE, 6-BROMO-1,3-DIHYDRO-;BROMOOXINDOLE (6-);6-Bromo-1,3-dihydro-2H-indol-2-one;6-Bromooxoindole
• CAS NO: 99365-40-9
• Molecular Formula: C₈H₆BrNO
• Molecular Weight: 212.04
• EINECS: 1312995-182-4
• Product Categories: blocks;Bromides;IndolesOxindoles;Indoline & Oxindole;Halogenated Heterocycles;Heterocyclic Building Blocks;Indoles;IndolesBuilding Blocks;Aromatics;Heterocycles;Indole Derivatives;Intermediates;Heterocycle-Indole series
• Mol File: 99365-40-9.mol

Chemical Properties

• Melting Point: 217-221 °C(lit.)
• Boiling Point: 343.6 °C at 760 mmHg
• Flash Point: 161.6 °C
• Appearance: light yelllow crystal
• Density: 1.666 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.698
• Storage Temp.: 2-8°C
• Solubility: DMSo
• PKA: 13.39±0.20(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 6-Bromo-1,3-dihydro-2H-indol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Bromo-1,3-dihydro-2H-indol-2-one(99365-40-9)
• EPA Substance Registry System: 6-Bromo-1,3-dihydro-2H-indol-2-one(99365-40-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-24/25
• WGK Germany: 3
• Hazardous Substances Data: 99365-40-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-Bromo-1,3-dihydro-2H-indol-2-one serves as an intermediate in the preparation of p38α inhibitors, which are considered potential anti-inflammatory agents. Its role in the synthesis of these inhibitors is crucial for developing new treatments aimed at managing inflammation-related conditions.
As an intermediate in pharmaceuticals, 6-Bromo-1,3-dihydro-2H-indol-2-one is used for the development of p38alpha inhibitors, which are being explored for their potential as anti-inflammatory medications. This application underscores its importance in the advancement of modern healthcare and therapeutics.

InChI:InChI=1/C8H4BrNO/c9-6-2-1-5-3-8(11)10-7(5)4-6/h1-4H

Upstream product

• 6127-11-3 (4-bromo-2-nitrophenyl)acetic acid 
• 100487-82-9 4-bromo-2-nitro-benzoic acid methyl ester 
• 100487-81-8 2-(4-bromo-2-nitro-phenyl)malonic acid dimethyl ester 
• 60956-26-5 4-bromo-2-nitrotoluene 
• 99365-39-6 3-(4-bromo-2-nitrophenyl)-2-oxopropanoic acid 
• 119-32-4 4-Methyl-3-nitroanilin 
• 7440-66-6 zinc 
• 199328-35-3 ethyl 2-(4-bromo-2-nitrophenyl)acetate 
• 199328-34-2 diethyl 2-(4-bromo-2-nitrophenyl)malonate 
• 6326-79-0 6-bromoisatin 
• 364-73-8 4-Bromo-1-fluoro-2-nitrobenzene 
• 552333-33-2 7-bromo-1H-isochromene-1,3(4H)-dione 
• 1355049-15-8 5-bromo-2-(2-methoxy-2-oxoethyl)benzoic acid 
• 1355049-16-9 methyl [2-(azidocarbonyl)-4-bromophenyl]acetate 

Downstream Products

• 99365-41-0 3-hydroxymethylene-6-bromooxindole 
• 848649-94-5 6-bromoindoline-2-thione 
• 865079-94-3 6-Bromo-3-[1-phenyl-meth-(E)-ylidene]-1,3-dihydro-indol-2-one 
• 258831-98-0 6-(4-fluoro-phenyl)-2-oxo-1,2-dihydro-indole 
• 90751-00-1 6-phenyl-2-oxindole 
• 893441-85-5 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indoline-2-one 
• 199327-63-4 6-cyano-1,3-dihydro-indol-2-one 
• 158326-84-2 6-Bromo-3,3-dimethyl-2-oxo-indole 
• 919103-45-0 6-iodo-1,3-dihydro-indol-2-one 
• 400629-18-7 6-[4-((1S)-1-methyl-2-[(methylethyl)sulfonyl]aminoethyl)phenyl]indolin-2-one 
• 1190861-76-7 6-bromo-3,3-bis(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)indolin-2-one 
• 1160247-29-9 tert-butyl 6-bromo-2-oxo-1,2-dihydrospiro[indole-3,4’-piperidine]-1‘-carboxylate 

Relevant articles and documents

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