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Calcium folinate

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Calcium folinate

EINECS 216-082-8
CAS No. 1492-18-8 Density
Solubility Melting Point 240-250oC
Formula C20H21N7O7.Ca Boiling Point
Molecular Weight 511.51 Flash Point
Transport Information Appearance Pale yellow crystalline powder
Safety 26-36-36/37-22 Risk Codes 36/37/38-42/43
Molecular Structure Molecular Structure of 1492-18-8 (Calcium folinate) Hazard Symbols HarmfulXn

Calcium leucovorin;Calcium folinate ;Calcium leucovorin;2-[[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]-5,5-dihydroxy-pentanoic acid;Folinic acid-SF, calcium salt;L-Glutamic acid,N-[4-[[(2-amino-5-formyl- 1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)- methyl]amino]benzoyl]-,calcium salt (1:1);Uzel;Folinic acid calcium;Calcium Folinate(Leucovorin calcium);Calcium folinate anhydrous;Leucovorin Calcium;


Calcium folinate Chemical Properties

Chemical Name: Calcium folinate
IUPAC NAME: Calcium 2-[[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioate
CAS No.: 1492-18-8
EINECS: 216-082-8
RTECS: MA0600500
RTECS Class: Drug
Molecular Formula: C20H21CaN7O7
Molecular Weight: 511.5 g/mol
Following is the structure of Folinic acid (CAS No.1492-18-8):

Product Categories: APIs ; Antitumors for Research and Experimental Use ; Biochemistry ; API's
The chemical synonymous of Folinic acid (CAS No.1492-18-8) are Calcium5-formyltetrahydrofolate ; Calciumsalt(1:1),l-yl)methyl)amino)benzoyl) ; Glutamicacid,n-(p-(((2-amino-5-formyl-5,6,7,8-tetrahydro-3-hydroxy-6-pteridin ; Lederfoline ; Leucovorincalciumsalt ; 5-Formlyl-5,6,7,8-tetrahydrofolic acid, calcium salt ; Leucovorin calcium

Calcium folinate Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1036mg/kg (1036mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.
mouse LD50 intravenous 732mg/kg (732mg/kg)   Drugs in Japan Vol. 6, Pg. 910, 1982.
mouse LD50 oral > 7gm/kg (7000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.
rat LD50 intraperitoneal 1063mg/kg (1063mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.
rat LD50 oral > 8gm/kg (8000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.

Calcium folinate Safety Profile

Hazard Codes: HarmfulXn
Risk Statements about Folinic acid (CAS No.1492-18-8):
R42/43: May cause sensitization by inhalation and skin contact. 
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements:
S22: Do not breathe dust. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36: Wear suitable protective clothing. 
S36/37: Wear suitable protective clothing and gloves.
1. Storage: Store in a tightly closed container. Keep under an argon blanket. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4 °C). Store protected from light and air.
2. Handling: Wash hands before eating. Use only in a well ventilated area. Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Keep container tightly closed. Store protected from light. Use and store under nitrogen. Store and handle protected from air. Wash clothing before reuse. Discard contaminated shoes.

Calcium folinate Specification

  Folinic acid (CAS No.1492-18-8), generally administered as calcium folinate (or leucovorin calcium), is an adjuvant used in cancer chemotherapy involving the drug methotrexate.It is also used in synergistic combination with the chemotherapy agent 5-fluorouracil.It is administered at the appropriate time following methotrexate as part of a total chemotherapeutic plan, where it may "rescue" bone marrow and gastrointestinal mucosa cells from methotrexate. There is no apparent effect on preexisting methotrexate-induced nephrotoxicity.While not specifically an antidote for methotrexate, folinic acid may also be useful in the treatment of acute methotrexate overdose. Different dosing protocols are used, but folinic acid should be re-dosed until the methotrexate level is less than 5 x 10-8 M.It is also used in combination with the chemotherapy agent 5-fluorouracil in treating colon cancer. In this case, folinic acid is not used for "rescue" purposes ; rather, it enhances the effect of 5-fluorouracil by inhibiting thymidylate synthase.

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