Barbier(-type) Reaction

P. Barbier, C. R. Acad. Sci. 128, 110 (1899).

One-step procedure for the preparation of alcohols from organic halides and aldehydes or ketones:



Review of mechanistic studies of Sm-mediated coupling: D. P. Curran et al., Synlett 1992, 943-961. Book: C. Blomberg, The Barbier Reaction and Related One-Step Processes, K. Hafner et al., Eds. (Springer-Verlag, New York, 1993) 183 pp. Zn-promoted coupling: F. Hong et al., Chem. Commun. 1994, 289. Sm-mediated coupling: M. Kunishima et al., Chem. Pharm. Bull. 42, 2190 (1994). Comparison with Ni(0) insertion chemistry for intramolecular cyclization: M. Kihara et al., Tetrahedron 48, 67 (1992). Cf. Grignard Reaction.