Schotten-Baumann Reaction

C. Schotten, Ber. 17, 2544 (1884); E. Baumann, ibid. 19, 3218 (1886).

Acylation of alcohols or amines with acid chlorides in aqueous alkaline solution:



Review: N. O. V. Sonntag, Chem. Rev. 52, 272-273 (1953). Synthetic applications: M. Tsuchiya et al., Bull. Chem. Soc. Japan 42, 1756 (1969); G. I. Georg, Bioorg. Med. Chem. Letters 4, 335 (1994).