- Bischler-Napieralski Reaction
-
Bischler-Napieralski Reaction
A. Bischler, B. Napieralski, Ber. 26, 1903 (1893).
Cyclodehydration of β-phenethylamides to 3,4-dihydro derivatives by means of condensing agents such as phosphorous pentoxide or zinc chloride:
W. M. Whaley, T. R. Govindachari, Org. React. 6, 74 (1951); T. Kametani et al., Tetrahedron 27, 5367 (1971); G. Fodor et al., Angew. Chem. Int. Ed. 11, 919 (1972); G. Fodor, S. Nagubandi, Tetrahedron 36, 1279 (1980); eidem, Heterocycles 15, 165 (1981). Review of enantioselective modifications: M. O. Rozwadowska, ibid. 39, 903-931 (1994). Cf. Bradsher Reaction; Pechmann Condensation; Pictet-Gams Isoquinoline Synthesis; Pictet-Hubert Reaction; Skraup Reaction.
Prev: Blaise Ketone Synthesis
Next: Bischler-Möhlau Indole Synthesis - 【Back】【Close 】【Print】【Add to favorite 】
- Related information
- Reaction routes of Metronidazole
- Reaction Kettle_008
- Production of 4-(2-Bromo-2-propenyl)-4-methyl-γ-butyrolactone by the Reaction of Ethyl levulinate with (2-bromoallyl)diisopropoxyborane
- Double Hydroxylation Reaction: 16α-Methylcortexolone
- Diels-Alder reaction: (1S-endo)-3-(Bicyclo[2.2.1]hept-5-en-2-ylcarbonyl)-2-oxazolidinone
- 4-(2-Bromo-2-propenyl)-4-methyl-gamma-butyrolactone: from the reaction of Ethyl levulinate and (2-Bromoallyl)diisopropoxyborane
- Synthesis of trans-4,4'-Dibromostilbene by a Double Heck Reaction of (Arylazo)amines with Vinyltriethoxysilane
- Single Displacement Reactions
- Reaction Design
- Chemical Reaction Stoichiometry (CRS, Tutorial, Java Applet, and Resources)
-
Health and Chemical more >
-
Hot Products
- 13314-52-8 DIETHYLGERMANIUM DICHLORIDE
- 50-81-7 L(+)-Ascorbic acid
- 14113-05-4 10-Hydroxy-2-decenoic acid
- 1029712-80-8 INCB28060
- 137863-17-3 L-Valine,N-(1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, methylester
- 83915-83-7 Lisinopril
- 446-36-6 5-Fluoro-2-nitrophenol
- 92-69-3 4-Phenylphenol
- 4640-67-9 4-FLUOROBENZOYLACETONITRILE
- 33665-90-6 Acesulfame
- 698-27-1 2-HYDROXY-4-METHYLBENZALDEHYDE
- 22888-70-6 Silymarin