Ehrlich-Sachs Reaction

P. Ehrlich, F. Sachs, Ber. 32, 2341 (1899).

Formation of N-phenylimines by the base-catalyzed condensation of compounds containing active methylene groups with aromatic nitroso compounds; nitrones also may be formed:



F. Barrow, F. J. Thorneycroft, J. Chem. Soc. 1939, 769; A. McGookin, J. Appl. Chem. 5, 65 (1955); F. Bell, J. Chem. Soc. 1957, 516; D. M. W. Anderson, F. Bell, ibid. 1959, 3708; D. M. W. Anderson, J. L. Duncan, ibid. 1961, 1631; W. Seidenfaden, Houben-Weyl 10/1, 1079 (1971). Applications: F. Millich, M. T. El-Shoubary, Org. Prep. Proced. Int. 28, 366 (1996); S. K. De et al., Can. J. Chem. 76, 199 (1998).