- Eschenmoser Coupling Reaction
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Eschenmoser Coupling Reaction (Sulfide Contraction)
A. Fischli, A. Eschenmoser, Angew. Chem. Int. Ed. 6, 866 (1967); M. Roth et al., Helv. Chim. Acta 54, 710 (1971).
Formation of vinylogous amides and urethanes by alkylation of secondary or tertiary thioamides with an electophilic agent followed by elimination of sulfur:
Synthetic applications: E. Götschi et al., Angew. Chem. Int. Ed. 12, 910 (1973); O. Sakurai et al., J. Org. Chem. 61, 7889 (1996), T. G. Minehan, Y. Kishi, Tetrahedron Letters 38, 6811 (1997). Review: K. Shiosaki, Comp. Org. Syn. 2, 865-894 (1991).
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