Lieben Iodoform Reaction (Haloform Reaction)

A. Lieben, Ann. (Suppl.) 7, 218 (1870).

Cleavage of methyl ketones with halogens (mostly iodine) and base to carboxylic acids and haloform:



R. C. Fuson, B. A. Bull, Chem. Rev. 15, 275 (1934); R. N. Seelye, T. A. Turney, J Chem. Ed. 36, 572 (1959); H. O. House, Modern Synthetic Reactions (W. A. Benjamin, Menlo Park, California, 2nd ed., 1972) pp 464-465; J. March, Advanced Organic Chemistry (Wiley-Interscience, New York, 4th ed., 1992) p 632.