Neber Rearrangement

P. W. Neber, A. v. Friedolsheim, Ann. 449, 109 (1926); P. W. Neber, G. Huh, ibid. 515, 283 (1935).

Formation of α-amino ketones by treatment of sulfonic esters of ketoximes with potassium ethoxide, followed by hydrolysis:



Reviews: C. O'Brien, Chem. Rev. 64, 81 (1964); C. G. McCarty in The Chemistry of the - Double Bond, S. Patai, Ed. (Interscience, New York, 1970) p 447; Y. Tamura et al., Synthesis 1973, 215; R. F. Parcell, J. C. Sanchez, J. Org. Chem. 46, 5229 (1981); K. Maruoka, H. Yamamoto, Comp. Org. Syn. 6, 786-789 (1991). Synthetic applications: I. Moldvai et al., Heterocycles 43, 2377 (1996); M. J. Mphahlele, T. A. Modro, , , Relat. Elem. 127, 131 (1997); J. Y. L. Chung et al., Tetrahedron Letters 40, 6739 (1999).