Prins Reaction

H. J. Prins, Chem. Weekblad 16, 64, 1072, 1510 (1919), C.A. 13, 3155 (1919).

Acid-catalyzed addition of olefins to formaldehyde to give 1,3-diols, allylic alcohols or meta-dioxanes:



Reviews: R. Arundale, L. A. Mikeska, Chem. Rev. 51, 505 (1952); V. I. Isagulyants et al., Russ. Chem. Rev. 1968, 17; C. W. Roberts in Friedel-Crafts and Related Reactions vol. 2, Part 2, G. A. Olah, Ed. (Interscience, 1964) pp 1175-1210; D. R. Adams, S. P. Bhatnagar, Synthesis 1977, 661; K. H. Schulte-Elte et al., Helv. Chim. Acta 62, 2673 (1979); R. El Gharbi et al., Synthesis 1981, 361; B. B. Snider, Comp. Org. Syn. 2, 527-561 (1991).