Traube Synthesis

W. Traube, Ber. 33, 1371, 3035 (1900).

Preparation of 4,5-diaminopyrimidines by introduction of the amino group into the 5-position of 4-amino-6-hydroxy- or 4,6-diaminopyrimidines by nitrosation and ammonium sulfide reduction, followed by ring closure with formic acid or chlorocarbonic ester:



J. H. Davidson, The Nucleic Acids I (New York, 1955) p 131; A. R. Katritzky, Quart. Rev. 10, 397 (1956); idem, Rev. Pure Appl. Chem. 11, 178 (1961); J. H. Lister, Purines (Wiley, New York, 1971) pp 31-90.