Zimmermann Reaction

W. Zimmermann, Z. Physiol. Chem. 233, 257 (1935).

The reaction that occurs between methylene ketones and aromatic polynitro compounds in the presence of alkali. When applied to 17-oxosteroids, the colored compounds formed can be used for the quantitative determination of 17-oxosteroids:



W. Zimmerman et al., ibid. 289, 91 (1952); idem. ibid. 300, 141 (1955). Studies on mechanism: Neunhoffer et al., ibid. 323, 116 (1961); Foster, Mackie, Tetrahedron 18, 1131 (1962); H. Hoffmeister, C. Rufer, Ber. 98, 2376 (1965); B. T. Rudd, O. M. Galal, Proc. Assoc. Clin. Biochem. 4, 175 (1967); C. S. Feldkamp et al., Microchem. J. 22, 201 (1977). Cf. Janovsky Reaction.