- Synthesis of Azelastine hydrochloride
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hydrochloride (CAS NO.: ), with other name of 4-(4-Chlorobenzyl)-2-(1-methylperhydroazepin-4-yl)phthalazin-1(2H)-one hydrochloride, could be produced through the following synthetic routes.
The cyclization of alpha-(p-chlorophenyl)acetophenone-o-carboxylic acid (I) with hydrazine sulfate by means of NaOH in water gives 4-(p-chlorobenzyl)-1-(2H)-phthalazinone (II), which is then condensed with 2-(2-chloroethyl)-N-methylpyrrolidine (III) by means of NaOH in hot water.
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