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 Preparation of Nimesulide
  • Preparation of Nimesulide
  • (CAS NO.: ), with other name of N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide, could be produced through the following synthetic routes.

    Preparation of Nimesulide

                         Preparation of Nimesulide

    Compound can be prepared in three different ways: 1) By nitration of 2-phenoxymethanesulfonanilide (I) with nitric acid in acetic acid. 2) By condensation of 2-phenoxy-4-nitroaniline (II) with methanesulfonyl chloride in pyridine. 3) By condensation of 2-bromo-4-nitromethanesulfonanilide (III) with phenol (A) by means of KOH and pyridine in benzene.


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