- Preparation of Nimesulide
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(CAS NO.: ), with other name of N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide, could be produced through the following synthetic routes.


Compound can be prepared in three different ways: 1) By nitration of 2-phenoxymethanesulfonanilide (I) with nitric acid in acetic acid. 2) By condensation of 2-phenoxy-4-nitroaniline (II) with methanesulfonyl chloride in pyridine. 3) By condensation of 2-bromo-4-nitromethanesulfonanilide (III) with phenol (A) by means of KOH and pyridine in benzene.
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