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70374-39-9

Basic Information
CAS No.: 70374-39-9
Name: Lornoxicam
Article Data: 3
Cas Database
Molecular Structure:
Molecular Structure of 70374-39-9 (Lornoxicam)
Formula: C13H10ClN3O4S2
Molecular Weight: 371.825
Synonyms: Chlortenoxicam;Lornoxicamum;6-Chloro-4-hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide;2H-Thieno(2,3-e)-1,2-thiazine-3-carboxamide, 6-chloro-4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide;
EINECS: 630-354-7
Density: 1.742 g/cm3
Melting Point: 225-230 °C (dec.)
Boiling Point: N/A
Flash Point: N/A
Solubility: N/A
Appearance: Crystalline solid
Hazard Symbols: IrritantXi
Risk Codes: 36/37/38
Safety: 26-36
Transport Information: N/A
PSA: 136.22000
LogP: 3.38760
Synthetic route

C14H14ClN3O5S2

70374-39-9

lornoxicam

Conditions
ConditionsYield
With sodium methylate for 2h; Reflux;87%
504-29-0

2-aminopyridine

70374-39-9

lornoxicam

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: benzotriazol-1-ol; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 2 h / Large scale
1.2: 1 h / 20 °C / Large scale
2.1: triethylamine / ethyl acetate / 0 - 20 °C / Large scale
3.1: sodium methylate / 2 h / Reflux
View Scheme
70374-39-9

lornoxicam

75-75-2

methanesulfonic acid

1608472-15-6

lornoxicam mesylate

Conditions
ConditionsYield
In ethanol for 1h; Milling;96%
70374-39-9

lornoxicam

15684-35-2

cobalt(II) tetrafluoroborate hexahydrate

56-40-6

glycine

[Co(lornoxicam)2(glycine)]BF4

Conditions
ConditionsYield
In ethanol for 2h; Reflux;96%
110-85-0

piperazine

70374-39-9

lornoxicam

lornoxicam piperazinium salt

Conditions
ConditionsYield
In ethanol for 1h; Milling;95%
70374-39-9

lornoxicam

chromium(III) chloride hexahydrate

56-40-6

glycine

[Cr(lornoxicam)2(glycine)]Cl2*3H2O

Conditions
ConditionsYield
In ethanol for 2h; Reflux;95%
70374-39-9

lornoxicam

iron(III) chloride hexahydrate

56-40-6

glycine

[Fe(lornoxicam)(glycine)(H2O)2]Cl2*H2O

Conditions
ConditionsYield
In ethanol for 2h; Reflux;95%
70374-39-9

lornoxicam

lornoxicam hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water for 0.75h; Milling;93%
70374-39-9

lornoxicam

nickel(II) chloride hexahydrate

56-40-6

glycine

[Ni(lornoxicam)2(glycine)]Cl

Conditions
ConditionsYield
In ethanol for 2h; Reflux;93%
70374-39-9

lornoxicam

iron(II) tetrafluoroborate hexahydrate

56-40-6

glycine

[Fe(lornoxicam)(glycine)(H2O)2]BF4*H2O

Conditions
ConditionsYield
In ethanol for 2h; Reflux;93%
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    Name:Lornoxicam The alias:AKOS 93662 ; 6-CHLORO-4-HYDROXY-2-METHYL-N-2-PYRIDINYL-2H-THIENO[2,3-; E]-1,2-THIAZINE-3-CARBOXAMIDE 1,1-DIOXIDE ; CAS NO:70374-39-9 Molecular formula:C13H10ClN3O4S2 Molecular weight:371.8192 Product Quality 12 yea

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Chemistry

Molecular structure of Lornoxicam (CAS NO.70374-39-9) is:

Product Name: Lornoxicam
CAS Registry Number: 70374-39-9
IUPAC Name: (3E)-6-chloro-3-[hydroxy-(pyridin-2-ylamino)methylidene]-2-methyl-1,1-dioxothieno[2,3-e]thiazin-4-one
Molecular Weight: 371.8192 [g/mol]
Molecular Formula: C13H10ClN3O4S2
XLogP3-AA: 3.1
H-Bond Donor: 2
H-Bond Acceptor: 7
Melting Point: 225-230°C (dec.)
Surface Tension: 91.82 dyne/cm
Density: 1.742 g/cm
Product Categories: APIs;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Fused Ring Systems

History

 Lornoxicam is found in the plasma in unchanged form and as its hydroxylated metabolite.

Uses

 Lornoxicam (CAS NO.70374-39-9) is a non-steroidal anti-inflammatory drug of the oxicam class,with analgesic ,anti-inflammatory and antipyretic propertiesis .It is used for inflammatory disease of the joints ,osteoarthritis,pain following surgery as well as pain in the lower back and hip which travels down the back of the thigh into the leg .

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD50 oral 5730ug/kg (5.73mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 94, Pg. 61, 1989.

Safety Profile

Hazard Codes: IrritantXi
Risk Statements: 36/37/38 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing.

Specification

 Lornoxicam , its cas register number is 70374-39-9. It also can be called 6-Chloro-4-hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide ; 2H-Thieno(2,3-e)-1,2-thiazine-3-carboxamide, 6-chloro-4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide ; Chlortenoxicam ; Lornoxicamum .It is a crystalline solid and available in oral and parenteral formulations. It is absorbed rapidly and almost completely from the gastro-intestinal tract.