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| CAS No.: | 70374-39-9 |
|---|---|
| Name: | Lornoxicam |
| Article Data: | 3 |
| Cas Database | |
| Molecular Structure: | |
|
|
|
| Formula: | C13H10ClN3O4S2 |
| Molecular Weight: | 371.825 |
| Synonyms: | Chlortenoxicam;Lornoxicamum;6-Chloro-4-hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide;2H-Thieno(2,3-e)-1,2-thiazine-3-carboxamide, 6-chloro-4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide; |
| EINECS: | 630-354-7 |
| Density: | 1.742 g/cm3 |
| Melting Point: | 225-230 °C (dec.) |
| Appearance: | Crystalline solid |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 36/37/38 |
| Safety: | 26-36 |
| PSA: | 136.22000 |
| LogP: | 3.38760 |
- 70374-51-56-Chloro-4-hydroxy-3-methoxycarbonyl-2H-thieno[2,3-e]-1,2-thiazine-1,1-dioxide
- 7037-49-24-Piperidinepropanol
- 70375-22-3Carbamic acid,[(1S)-4-[(aminoiminomethyl)amino]-1-[[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)amino]carbonyl]butyl]-,phenylmethyl ester, monohydrochloride (9CI)
- 70375-24-5L-Argininamide,N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-L-prolyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-,monohydrochloride (9CI)
- 703-80-0Ethanone,1-(1H-indol-3-yl)-
- 70380-50-6Glycine,N-[(2,3-dichloro-6-nitrophenyl)methyl]-, ethyl ester, hydrochloride (1:1)
- 70380-67-5Oxazole, 5-(2-furanyl)-
- 70380-70-0Oxazole, 5-(2-thienyl)-
- 70380-73-3Pyridine,2-(5-oxazolyl)-
- 70380-74-4Pyridine,3-(5-oxazolyl)-
- 70374-39-9
lornoxicam
| Conditions | Yield |
|---|---|
| With sodium methylate for 2h; Reflux; | 87% |
- 504-29-0
2-aminopyridine
- 70374-39-9
lornoxicam
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1.1: benzotriazol-1-ol; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 2 h / Large scale 1.2: 1 h / 20 °C / Large scale 2.1: triethylamine / ethyl acetate / 0 - 20 °C / Large scale 3.1: sodium methylate / 2 h / Reflux View Scheme |
| Conditions | Yield |
|---|---|
| In ethanol for 1h; Milling; | 96% |
| Conditions | Yield |
|---|---|
| In ethanol for 2h; Reflux; | 96% |
| Conditions | Yield |
|---|---|
| In ethanol for 1h; Milling; | 95% |
- 70374-39-9
lornoxicam
| Conditions | Yield |
|---|---|
| With hydrogenchloride In ethanol; water for 0.75h; Milling; | 93% |
| Conditions | Yield |
|---|---|
| In ethanol for 2h; Reflux; | 93% |
- 22348-32-92-Pyrrolidinemethanol,a,a-diphenyl-, (2R)-
- 103041-38-9Ethyl 3-(pyridin-2-ylamino)propanoate
- 41100-52-1Memantine hydrochloride
- 132335-44-5(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine
- 7235-40-7beta-Carotene
- 52-51-71,3-Propanediol,2-bromo-2-nitro-
- 132539-06-110H-Thieno[2,3-b][1,5]benzodiazepine, 2-methyl-4-(4-methyl-1-piperazinyl)-
- 24424-99-5Di-tert-butyl dicarbonate
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
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Chemistry
Molecular structure of Lornoxicam (CAS NO.70374-39-9) is:
Product Name: Lornoxicam
CAS Registry Number: 70374-39-9
IUPAC Name: (3E)-6-chloro-3-[hydroxy-(pyridin-2-ylamino)methylidene]-2-methyl-1,1-dioxothieno[2,3-e]thiazin-4-one
Molecular Weight: 371.8192 [g/mol]
Molecular Formula: C13H10ClN3O4S2
XLogP3-AA: 3.1
H-Bond Donor: 2
H-Bond Acceptor: 7
Melting Point: 225-230°C (dec.)
Surface Tension: 91.82 dyne/cm
Density: 1.742 g/cm3
Product Categories: APIs;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Fused Ring Systems
History
Lornoxicam is found in the plasma in unchanged form and as its hydroxylated metabolite.
Uses
Lornoxicam (CAS NO.70374-39-9) is a non-steroidal anti-inflammatory drug of the oxicam class,with analgesic ,anti-inflammatory and antipyretic propertiesis .It is used for inflammatory disease of the joints ,osteoarthritis,pain following surgery as well as pain in the lower back and hip which travels down the back of the thigh into the leg .
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| rat | LD50 | oral | 5730ug/kg (5.73mg/kg) | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 94, Pg. 61, 1989. |
Safety Profile
Hazard Codes: 
Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
Specification
Lornoxicam , its cas register number is 70374-39-9. It also can be called 6-Chloro-4-hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide ; 2H-Thieno(2,3-e)-1,2-thiazine-3-carboxamide, 6-chloro-4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide ; Chlortenoxicam ; Lornoxicamum .It is a crystalline solid and available in oral and parenteral formulations. It is absorbed rapidly and almost completely from the gastro-intestinal tract.