CAS No.70374-39-9,Lornoxicam Suppliers

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Basic Information

Molecular Structure:
CAS No.:	70374-39-9
Name:	Lornoxicam
Article Data:	3

Formula:	C₁₃H₁₀ClN₃O₄S₂
Molecular Weight:	371.825
Synonyms:	Chlortenoxicam;Lornoxicamum;6-Chloro-4-hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide;2H-Thieno(2,3-e)-1,2-thiazine-3-carboxamide, 6-chloro-4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide;
EINECS:	630-354-7
Density:	1.742 g/cm³
Melting Point:	225-230 °C (dec.)
Appearance:	Crystalline solid
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	26-36
PSA:	136.22000
LogP:	3.38760

Synthetic route

: C14H14ClN3O5S2

: 70374-39-9
lornoxicam

Conditions

Conditions	Yield
With sodium methylate for 2h; Reflux;	87%

: 504-29-0
2-aminopyridine

: 70374-39-9
lornoxicam

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: benzotriazol-1-ol; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 2 h / Large scale 1.2: 1 h / 20 °C / Large scale 2.1: triethylamine / ethyl acetate / 0 - 20 °C / Large scale 3.1: sodium methylate / 2 h / Reflux View Scheme

: 70374-39-9
lornoxicam

: 75-75-2
methanesulfonic acid

: 1608472-15-6
lornoxicam mesylate

Conditions

Conditions	Yield
In ethanol for 1h; Milling;	96%

: 70374-39-9
lornoxicam

: 15684-35-2
cobalt(II) tetrafluoroborate hexahydrate

: 56-40-6
glycine

: [Co(lornoxicam)2(glycine)]BF4

Conditions

Conditions	Yield
In ethanol for 2h; Reflux;	96%

...Expand

: 110-85-0
piperazine

: 70374-39-9
lornoxicam

: lornoxicam piperazinium salt

Conditions

Conditions	Yield
In ethanol for 1h; Milling;	95%

: 70374-39-9
lornoxicam

: chromium(III) chloride hexahydrate

: 56-40-6
glycine

: [Cr(lornoxicam)2(glycine)]Cl2*3H2O

Conditions

Conditions	Yield
In ethanol for 2h; Reflux;	95%

...Expand

: 70374-39-9
lornoxicam

: iron(III) chloride hexahydrate

: 56-40-6
glycine

: [Fe(lornoxicam)(glycine)(H2O)2]Cl2*H2O

Conditions

Conditions	Yield
In ethanol for 2h; Reflux;	95%

...Expand

: 70374-39-9
lornoxicam

: lornoxicam hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water for 0.75h; Milling;	93%

: 70374-39-9
lornoxicam

: nickel(II) chloride hexahydrate

: 56-40-6
glycine

: [Ni(lornoxicam)2(glycine)]Cl

Conditions

Conditions	Yield
In ethanol for 2h; Reflux;	93%

...Expand

: 70374-39-9
lornoxicam

: iron(II) tetrafluoroborate hexahydrate

: 56-40-6
glycine

: [Fe(lornoxicam)(glycine)(H2O)2]BF4*H2O

Conditions

Conditions	Yield
In ethanol for 2h; Reflux;	93%

...Expand

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Chemistry

Molecular structure of Lornoxicam (CAS NO.70374-39-9) is:

Product Name: Lornoxicam
CAS Registry Number: 70374-39-9
IUPAC Name: (3E)-6-chloro-3-[hydroxy-(pyridin-2-ylamino)methylidene]-2-methyl-1,1-dioxothieno[2,3-e]thiazin-4-one
Molecular Weight: 371.8192 [g/mol]
Molecular Formula: C₁₃H₁₀ClN₃O₄S₂
XLogP3-AA: 3.1
H-Bond Donor: 2
H-Bond Acceptor: 7
Melting Point: 225-230°C (dec.)
Surface Tension: 91.82 dyne/cm
Density: 1.742 g/cm³Product Categories: APIs;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Fused Ring Systems

History

Lornoxicam is found in the plasma in unchanged form and as its hydroxylated metabolite.

Uses

Lornoxicam (CAS NO.70374-39-9) is a non-steroidal anti-inflammatory drug of the oxicam class,with analgesic ,anti-inflammatory and antipyretic propertiesis .It is used for inflammatory disease of the joints ,osteoarthritis,pain following surgery as well as pain in the lower back and hip which travels down the back of the thigh into the leg .

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rat	LD50	oral	5730ug/kg (5.73mg/kg)		Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 94, Pg. 61, 1989.

Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.

Specification

Lornoxicam , its cas register number is 70374-39-9. It also can be called 6-Chloro-4-hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide ; 2H-Thieno(2,3-e)-1,2-thiazine-3-carboxamide, 6-chloro-4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide ; Chlortenoxicam ; Lornoxicamum .It is a crystalline solid and available in oral and parenteral formulations. It is absorbed rapidly and almost completely from the gastro-intestinal tract.