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70374-39-9

Basic Information
CAS No.: 70374-39-9
Name: Lornoxicam
Molecular Structure:
Molecular Structure of 70374-39-9 (Lornoxicam)
Formula: C13H10ClN3O4S2
Molecular Weight: 371.82
Synonyms: Chlortenoxicam;Lornoxicamum;6-Chloro-4-hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide;2H-Thieno(2,3-e)-1,2-thiazine-3-carboxamide, 6-chloro-4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide;
EINECS: 630-354-7
Density: 1.742 g/cm3
Melting Point: 225-230 °C (dec.)
Boiling Point:
Flash Point:
Solubility:
Appearance: Crystalline solid
Hazard Symbols: IrritantXi
Risk Codes: 36/37/38
Safety: 26-36
Transport Information:
PSA: 136.22000
LogP: 3.38760
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Chemistry

Molecular structure of Lornoxicam (CAS NO.70374-39-9) is:

Product Name: Lornoxicam
CAS Registry Number: 70374-39-9
IUPAC Name: (3E)-6-chloro-3-[hydroxy-(pyridin-2-ylamino)methylidene]-2-methyl-1,1-dioxothieno[2,3-e]thiazin-4-one
Molecular Weight: 371.8192 [g/mol]
Molecular Formula: C13H10ClN3O4S2
XLogP3-AA: 3.1
H-Bond Donor: 2
H-Bond Acceptor: 7
Melting Point: 225-230°C (dec.)
Surface Tension: 91.82 dyne/cm
Density: 1.742 g/cm
Product Categories: APIs;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Fused Ring Systems

History

 Lornoxicam is found in the plasma in unchanged form and as its hydroxylated metabolite.

Uses

 Lornoxicam (CAS NO.70374-39-9) is a non-steroidal anti-inflammatory drug of the oxicam class,with analgesic ,anti-inflammatory and antipyretic propertiesis .It is used for inflammatory disease of the joints ,osteoarthritis,pain following surgery as well as pain in the lower back and hip which travels down the back of the thigh into the leg .

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD50 oral 5730ug/kg (5.73mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 94, Pg. 61, 1989.

Safety Profile

Hazard Codes: IrritantXi
Risk Statements: 36/37/38 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing.

Specification

 Lornoxicam , its cas register number is 70374-39-9. It also can be called 6-Chloro-4-hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide ; 2H-Thieno(2,3-e)-1,2-thiazine-3-carboxamide, 6-chloro-4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide ; Chlortenoxicam ; Lornoxicamum .It is a crystalline solid and available in oral and parenteral formulations. It is absorbed rapidly and almost completely from the gastro-intestinal tract.