Desflurane (CAS NO.: 57041-67-5), with other name of Ethane, 2-(difluoromethoxy)-1,1,1,2-tetrafluoro-, (+-)-, could be produced through many synthetic methods.

Following are some of the synthesis routes:
The final product can be obtained by fluorination of isoflurane [2-(difluoromethoxy)-2-chloro-1,1,1-trifluorethane] (II) in three different ways:
1) With fluorine in argon at -10 °C.
2) With KF in diethyl glycon at 195 °C.
3) With BrF₃ at room temperature.