- Synthesis of Cefuroxime axetil
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e axetil (CAS NO.: ), with other name of 1-acetoxyethyl ester, could be produced through many synthetic methods.
Following is one of the reaction routes: The reaction of 3-hydroxymethyl-7-[2-(2-furyl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylic acid (I) with chlorosulfonyl isocyanate (II) and then with sodium 2-ethylhexanoate gives sodium cefuroxime (III), which is then treated with 1-bromoethyl acetate (IV) in .
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