(CAS NO.: ), with other name of , 5'-deoxy-5-fluoro-, could be produced through many synthetic methods.

Following is one of the reaction routes:

The condensation of bis(trimethylsilyl)fluorouracil (I) with 5-deoxy-1,2,3-tri-O-acetyl-D-ribofuranose (II) in the presence of trimethylsilyl trifluoromethanesulfonate (III) gives the fully protected compound (IV), which is finally deprotected by the usual methods.